Protein Alignment CG30456 and tiam-1

DIOPT Version :9

• Sequence 1: NP_611188.3
• Gene: CG30456 / 36929
• FlyBaseID: FBgn0050456
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_491367.3
• Gene: tiam-1 / 259373
• WormBaseID: WBGene00015704
• Length: 889
• Species: Caenorhabditis elegans
• Alignment Length: 641
• Identity: 121/641 - (18%)
• Similarity: 231/641 - (36%)
• Gaps: 181/641 - (28%)

  Fly    32 SHQAAEQERHSSTLVSSNLESNDVARPVSSVSSSSSSIQ------LSYSVNSDTDSSYRHRSLLK 90
            :|....|..:.|:|:.:...||.||  ::.::..:..||      |..|.:|:..|....|.:|.
 Worm   207 AHLFLIQALNVSSLLLARTTSNLVA--INYLARQNDKIQQKLIALLETSESSENASKEDIRQMLL 269

  Fly    91 MHE---AESVGGLGTESTP-----ESPMSPQTPD--------PALLDVRQKVHRFEAFR------ 133
            :..   .:.:..|...:.|     :..:|||...        |:|......::.|..:|
 Worm   270 LKNVVVTQRLNSLQQRALPGIELIQHDISPQIDQKLLEKCRLPSLFLYHFNMNSFRIWRKPMETR 334

  Fly   134 ------TNICFIKQERHSLKLLENRRHP----SFEDQSEDHHTPP-------------ATPPRRI 175
                  :::....| .|.:.:....::|    ..:.|.:..:.||             .|.|.:.
 Worm   335 DMNTMGSSMASTSQ-YHQIPIQIQNQNPLPSQQIQPQQQQQYHPPDHVTTHNGTTTFHTTNPTKP 398

  Fly   176 RL------PGLGSRGSSRSSSIPSFQAGIHEVRSEDEVDQISDFETDSHTAAEEYLVVDTTSE-- 232
            ||      ||.....:|             |.|..:..:|..:....|  :||:|.|..|...
 Worm   399 RLCEGSLAPGCSLAEAS-------------EQRKREMAEQKKELAGPS--SAEDYFVRKTNGRLG 448

  Fly   233 ----------VVPSE------------EVADS--KVDQQQVQRSISADQSKEALTL--PLKMRND 271
                      |:.:|            :|.||  .||.:.:....:|...::.|.:  .:.:|..
 Worm   449 LTIYAHNDDGVIRAEVRGVTSFAPRCAQVGDSVVAVDSELISSVRNASDVEKLLRIGKVIHLRRK 513

  Fly   272 FPRNYRSTPRRKTEIIGTTNEHLVGKFHSVYQPKDEEEEVEIELRDKSDKC--VHPILEELIKTE 334
            .|    .|||..:::..|.                         .:|...|  :...|:||:.||
 Worm   514 TP----LTPRAPSQLDATN-------------------------VNKKTGCAKLAMALQELLVTE 549

  Fly   335 EAYVNNLFTGIENYGNIFQRKDL---PLGLRGKKYDLFGNIEQ-IAEFHRDEFLPMLQRNRRDLK 395
            :.||::|....|.:..:.|.:|:   .:.|...:.....:||: |.:..|.:.  .:.:.|..:.
 Worm   550 KKYVSDLREMNEVFLCMRQVRDIMNAAIRLYKMQTSFVDSIEEAIGDMSRQDI--SVAQIRDSVM 612

  Fly   396 RLFDEFLQFLDQHCFY-----GYVIF---TMNKQKSLKLCDLYKNYFTSIRLERDDKLGINSFLV 452
            |:...|:........|     ||.:.   ..||::.|...:       ::...|:......|.::
 Worm   613 RVCAVFINKCSDFKIYAEYAAGYHLLQHEIKNKKELLSKLE-------AVNSTREQHCSWESRMI 670

  Fly   453 QPIQRMARYPLLLTQFINTFFKN-RDIVMKPLIESCCRLEKRLRALLTTTNESEIINDIVDCHEF 516
            :|:||:.:|||||....:...|: |:.|         ::|..|:.:.|:   :|.:|::...||.
 Worm   671 KPVQRIVQYPLLLKNIADALPKDARERV---------QVEAALQKMQTS---AEYVNEMQRLHED 723

  Fly   517 NVYYQGKFRKVNEFQVLDHKLKRSYRSKVFIFDKCIIYTEIKGKNLLFHGRYPCEH 572
            ...|....||.||..:.:..|:...|       :.:::..||.::.      |.||
 Worm   724 YAQYMETVRKANEPMLAEKSLRLDTR-------ELLVFAHIKWRDA------PAEH 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30456	NP_611188.3	RhoGEF	326..470	CDD:279015	35/155 (23%)
tiam-1	NP_491367.3	RhoGEF	541..715	CDD:238091	42/194 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960