DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30456 and gef1

DIOPT Version :9

Sequence 1:	NP_611188.3	Gene:	CG30456 / 36929	FlyBaseID:	FBgn0050456	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_592943.1	Gene:	gef1 / 2542635	PomBaseID:	SPAC24H6.09	Length:	753	Species:	Schizosaccharomyces pombe

Alignment Length:	569	Identity:	133/569 - (23%)
Similarity:	206/569 - (36%)	Gaps:	197/569 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADEDLSPLPFRRERNLSNRNFNKRNSRRRISHQAAEQERHSSTLVSSNLESNDVARPVSSVSSS 65
            ::|...||..|   ..|:||:..:.....:: |:||..:|.|..|                 |..
pombe     8 LSDMSDSPEYF---ETLANRDLPRLPGTSKL-HRAACIKRKSINL-----------------SLP 51

  Fly    66 SSSIQLSYSVNSDTD-------SSYRHRSLLKMHEAESVGGLGTESTPESPMSPQTPDPALLDVR 123
            |:|..|||..:.|||       |.||..|          |.....|...:...||||:...:..:
pombe    52 SNSYSLSYRQSDDTDGDVSESQSEYRLSS----------GRRSRASFARALQDPQTPNTPPVSSQ 106

  Fly   124 QKVHR-------FEAFRTNICFIKQERHSLK----------LLENR----RHPSFEDQSEDHHTP 167
               ||       |....:|:      .|||.          |..||    |:.....||..:..|
pombe   107 ---HRRFFSEGSFNLPNSNM------SHSLNGDSTASNSSTLTPNRIYGDRNRQDYAQSSRYTLP 162

  Fly   168 --PATPP-------RRI-----------RLPGLGS---RGSSRSSS------IPSFQAGIHEVRS 203
              |::|.       |:|           |:.||||   :.||.:||      :|.......|.||
pombe   163 SLPSSPSYNCPTTLRKIHTNTSSNGTSRRVSGLGSFMAQNSSETSSNRTSAYLPGSSTDEQEKRS 227

  Fly   204 EDEVDQISDFETDSHTAAEEYL-VVDTTSEVVPSEEVADSKVDQQQVQRSISADQSKEALTLPLK 267
            ...:..:    ..||::....| .:||||    .....||.:...:...|:|...|....:||
pombe   228 SVTLASM----PSSHSSTASLLSPLDTTS----FSTKLDSTILALETDESLSRTISYATTSLP-- 282

  Fly   268 MRNDFPRNYRSTPRRKTEIIGTTNEHLVGKFHSVYQPKDEEEEVEIELRDKSDKCVHPILEELIK 332
                      |||.::     .:.|.|.....|...|    |...|:.|..       :::||:.
pombe   283 ----------STPGKR-----LSKESLAMSEASSINP----EYKRIKKRAN-------LIKELVT 321

  Fly   333 TEEAYVNNLFTGIENYGNIFQRKDLPLGLRGKK---------YDLFGNIEQI----AEFHRDEF- 383
            ||.||:|:|....::|           |||.|:         ..:||:||.:    .|||...:
pombe   322 TEAAYLNDLIAIQQSY-----------GLRVKECSALNPVDAQTVFGDIESLLTFTVEFHSRLYQ 375

  Fly   384 -----------------LPMLQRNRRDLKRLFDEFLQFLDQHCFYGYVIFTMNKQKSL-KLCDLY 430
                             ||.      :|..:|.|.|..:.| .:.||    .|:|.|: |:...:
pombe   376 AGEGSWRVNLDTQLIDPLPC------NLGLIFLESLSEIGQ-IYTGY----CNRQDSVFKIITKW 429

  Fly   431 KNY-FTSIRLERDDKL--------GINSFLVQPIQRMARYPLLLTQFIN 470
            :.. .|:..:...||:        .:.|.:::|:||:.:|||||.:.|:
pombe   430 REKPATASWIMEGDKIVQKYTNAWDLGSLIIKPLQRLLKYPLLLQKIID 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30456	NP_611188.3	RhoGEF	326..470	CDD:279015	45/184 (24%)
gef1	NP_592943.1	RhoGEF	312..505	CDD:238091	47/196 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960