Protein Alignment CG30456 and MCF2L

DIOPT Version :9

• Sequence 1: NP_611188.3
• Gene: CG30456 / 36929
• FlyBaseID: FBgn0050456
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: XP_011535788.2
• Gene: MCF2L / 23263
• HGNCID: 14576
• Length: 1238
• Species: Homo sapiens
• Alignment Length: 805
• Identity: 167/805 - (20%)
• Similarity: 286/805 - (35%)
• Gaps: 227/805 - (28%)

  Fly    34 QAAEQERHSSTLVSSNLESNDVARPVSSVSSSSSSIQLSYSVNSDTDSSYRHRSLLKMHEA-ESV 97
            |.|:..:...|.::.....|||        .|:||:..:::...|........:|.:.|.. ||:
Human   270 QTAQMLQSFGTELAETELPNDV--------QSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESL 326

  Fly    98 GGLGTESTPESPMSPQTPDPA-----LLDVRQKVHRFEAF------RTNICFIKQERH------- 144
            ..|..|.:..|....|..:.|     |..:.:....|:.|      :...|.  |.||
Human   327 RELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCL--QLRHFEQGFRE 389

  Fly   145 --------------------SLKLLEN--RRHPSFEDQS-------------------EDHHTPP 168
                                ||..:|:  |...|||::|                   ..|:...
Human   390 VKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVD 454

  Fly   169 ATPPRRIRLPGLGSRGSSR------------------SSSIPSFQAGIHEVRS------------ 203
            :..|:...|..|..:.|:.                  .:|:.....||:.:.|
Human   455 SIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGA 519

  Fly   204 EDEVDQISDF-ETDSHTAAEEYLVVDTTSEVVPSEEVAD--SKVDQQQV-------QRSISADQS 258
            |..:.:|..| ||.:....:|...:....|.:.::::.:  .||.|:|.       :|..|..:.
Human   520 EAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKL 584

  Fly   259 KEALTLPLKMRNDFPRNYRSTP--------------------------RRKTEIIGTTNEHLVGK 297
            ....|.|::.....|.....:|                          |.|:|:    :|...|:
Human   585 AARQTRPVQPVAPRPEALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEM----SESRQGR 645

  Fly   298 FHSVYQPKDEEEEVEIELRDKSDKCVHPILEELIKTEEAYVNNLFTGIENYGNIFQRKDLPL--- 359
            ..:    .:|||.:.|..|.        ::.||:.||.|||..|...:|.|.   ...|.||
Human   646 GSA----GEEEESLAILRRH--------VMSELLDTERAYVEELLCVLEGYA---AEMDNPLMAH 695

  Fly   360 ----GLRGKKYDLFGNIEQIAEFHRDEFLPMLQRNRRDLKRLFDE-FLQFLDQHCFYGYVIFTMN 419
                ||..||..||||:|:|..||...||..|: |..|...|... ||:.::.  |..|..:..|
Human   696 LLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELE-NYTDCPELVGRCFLERMED--FQIYEKYCQN 757

  Fly   420 KQKSLKL------CDLYKNYFTSIRLERDDKLGINSFLVQPIQRMARYPLLLTQFINTFFKNRDI 478
            |.:|..|      |.    :|...:.:.|.||.::|:|::|:||:.:|.|||.:.:. :.:|
Human   758 KPRSESLWRQCSDCP----FFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLK-YSRN--- 814

  Fly   479 VMKPLIESCCRLEKRLRALLTTTNESEIIND-----IVDCHEFNVYYQGKFRKVNEFQV-LDH-- 535
                    |...|....||.:.....:.:||     .:..::.|:...||......|.| .||
Human   815 --------CEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKR 871

  Fly   536 ---KLKRSYRSK-----VFIFDKCIIYTEIKGKNLLFHGRYP---------CEHIGIS----AKT 579
               |:|...|.|     :|:.:|.:::.:.:.:|...:.:.|         ...:||:    ...
Human   872 GHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDA 936

  Fly   580 KSFTLYYERRKQQECEFTADPVQIAIWLDLIRDMINNYANEERQKLQERYSRENDHLHRKAPSFS 644
            |.|.::|..|::........|...|.|::.||.::.:.....|:..|.|...::..|...||:
Human   937 KKFEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPT-- 999

  Fly   645 LYRDSNRFSSDSGIGNIWIMPKADE 669
                    |:....||...:.|.:|
Human  1000 --------STSPSRGNSRNIKKLEE 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30456	NP_611188.3	RhoGEF	326..470	CDD:279015	53/157 (34%)
MCF2L	XP_011535788.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910