DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30456 and Mcf2l

DIOPT Version :9

Sequence 1:	NP_611188.3	Gene:	CG30456 / 36929	FlyBaseID:	FBgn0050456	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001357978.1	Gene:	Mcf2l / 17207	MGIID:	103263	Length:	1178	Species:	Mus musculus

Alignment Length:	735	Identity:	157/735 - (21%)
Similarity:	281/735 - (38%)	Gaps:	195/735 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 ESNDVARPVSSVSSSSSSIQLSYSVNSD--TDSSYRHRSLLKMHEAESV---------------- 97
            |.|.:...:....:.|:    ::|||.|  .:.:...|.|.:::|.|:.
Mouse   261 EGNSILESLREPLAESA----AHSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCL 321

  Fly    98 ------GGLGTESTPESPMSPQTP-----DPALLDVRQKVHRFEAF--RTNICFIKQERHSL--- 146
                  .|.....|....||.:..     ..:|..|:..:....||  ::::...|....||
Mouse   322 QLRHFEQGFREVKTTLDSMSQKIAAFTDVGNSLAHVQHLLKDLTAFEEKSSVAVDKARALSLEGQ 386

  Fly   147 KLLENRR------HPSFEDQSE--DHHTPPATPPRRIRLPG--------------------LGSR 183
            :|:|||.      ||..|:...  ||.....|..|.:....                    |.|:
Mouse   387 QLIENRHYAVDSIHPKCEELQHLCDHFASEVTRRRGLLSKSLELHSLLETSMKWSDEGIFLLASQ 451

  Fly   184 GSSRSSSIPSFQAGIHEVR------SEDEVDQISDFETDSHTAAEEYLVVDTTSEVVPSEEVADS 242
            ...:..|....:|.:.|:.      :|:::.::::...:......:.| ::...:|...:|..:.
Mouse   452 PVDKCQSQDGAEAALQEIEKFLETGAENKIQELNEIYKEYECILNQDL-LEHVQKVFQKQESTEE 515

  Fly   243 KVDQQQVQ-RSISADQSK---------EALTLPLKMRNDFPRNYRSTP---------------RR 282
            ...::|.. :.::|.|::         ||||   |..:..|.::||:.               |.
Mouse   516 MFHRRQASLKKLAAKQTRPVQPVAPRPEALT---KSPSPSPGSWRSSENSSSEGNALRRGPYRRA 577

  Fly   283 KTEIIGTTNEHLVGKFHSVYQPKDEEEEVEIELRDKSDKCVHPILEELIKTEEAYVNNLFTGIEN 347
            |:|:    :|...|:..|.   .:|||.:.|..|.        ::.||:.||.|||..|...:|.
Mouse   578 KSEM----SEPRQGRTSST---GEEEESLAILRRH--------VMNELLDTERAYVEELLCVLEG 627

  Fly   348 YGNIFQRKDLPL-------GLRGKKYDLFGNIEQIAEFHRDEFLPMLQR--------NRRDLKRL 397
            |.   ...|.||       ||:.||..||||:|:|..||...||..|:.        .|..|:|:
Mouse   628 YA---AEMDNPLMAHLISTGLQNKKNILFGNMEEIYHFHNRIFLRELESCIDCPELVGRCFLERM 689

  Fly   398 FDEFLQFLDQHCFYGYVIFTMNKQKSLKL------CDLYKNYFTSIRLERDDKLGINSFLVQPIQ 456
             :|| |..:::|        .||.:|..|      |.    :|...:.:.|.||.::|:|::|:|
Mouse   690 -EEF-QIYEKYC--------QNKPRSESLWRQCSDCP----FFQECQKKLDHKLSLDSYLLKPVQ 740

  Fly   457 RMARYPLLLTQFINTFFKNRDIVMKPLIESCCRLEKRLRALLTTTNESEIIND-----IVDCHEF 516
            |:.:|.|||.:.:. :.|:           |...|....||.:.....:.:||     .:..::.
Mouse   741 RITKYQLLLKEMLK-YSKH-----------CEGAEDLQEALSSILGILKAVNDSMHLIAITGYDG 793

  Fly   517 NVYYQGKFRKVNEFQV-LDH-----KLKRSYRSK-----VFIFDKCIIYTEIKGKNLLFHGRYP- 569
            |:...||......|.| .||     |:|...|.|     :|:.:|.:::.:.:.:|...:.:.|
Mouse   794 NLGDLGKLLMQGSFSVWTDHKKGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPS 858

  Fly   570 --------CEHIGIS----AKTKSFTLYYERRKQQECEFTADPVQIAIWLDLIRDMINNYANEER 622
                    ...:||:    ..||.|.::|..|::........|...|.|::.||.::.:.....|
Mouse   859 YSYKQSLNMTAVGITENVKGDTKKFEIWYNAREEVYIIQAPTPEIKAAWVNEIRKVLTSQLQACR 923

  Fly   623 QKLQERYSRENDHLHRKAPS 642
            :..|.|...::..|....||
Mouse   924 EASQHRALEQSHSLPLPTPS 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30456	NP_611188.3	RhoGEF	326..470	CDD:279015	53/164 (32%)
Mcf2l	NP_001357978.1	SEC14	46..191	CDD:214706
		SPEC	322..524	CDD:238103	32/202 (16%)
		RhoGEF	603..780	CDD:238091	59/213 (28%)
		PH_Dbs	787..918	CDD:269934	27/130 (21%)
		SH3_DBS	1082..1136	CDD:212791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910