Protein Alignment CG46491 and Plekhg4

DIOPT Version :10

• Sequence 1: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: XP_006530585.2
• Gene: Plekhg4 / 102075
• MGIID: 2142544
• Length: 1235
• Species: Mus musculus
• Alignment Length: 552
• Identity: 128/552 - (23%)
• Similarity: 220/552 - (39%)
• Gaps: 114/552 - (20%)

  Fly   118 ALLDVRQKV----HRFEAFRTNICFIKQERHSLKLLENRRHPSFEDQSEDHHT-PPATPPRRIR- 176
            ||...||::    ..|:.|:....:.::.|..|..||..|......:.:.|.| .|..||...|
Mouse   572 ALAQRRQRLADAEKLFQFFKQASTWTEEGRRLLTELEQERPEVVLQRLQLHWTRHPDLPPAHFRK 636

  Fly   177 ----LPGLGSRGSSRSSSIPSFQAGIHEVRSEDEVDQISDFETDSHTAAEEYLVVDTTSEVVPSE 237
                ..||||.|                :|.|.........:|        :|.:|...|.....
Mouse   637 MWALATGLGSEG----------------IRQECRCAWAQCQDT--------WLALDQKREAALKP 677

  Fly   238 EVADSKVDQQQVQRSISADQSKEALTLPLKMRNDFPRNYRSTPRRKTEIIGTTNEHLVGKFHSVY 302
            ..|.:......|:|:.:.     ....||:....|.||   ..|...::  ::..|........:
Mouse   678 MPATNNTATLYVRRAPAV-----PTVPPLRKAYSFDRN---LGRHLQDV--SSRGHCAAIVTDCH 732

  Fly   303 QPKDE-----EEEVEIELRDKSD----KCVHPILEELIKTEEAYVNNLFTGIENYGNIFQRKDLP 358
            :|:..     .....:.|...||    ..:..:|.|::.||..||..|...|:||.....|.|:|
Mouse   733 RPEARGGVRPRSSPPVPLSGSSDFRSPNRLQLVLAEMVATEREYVRALDYTIQNYFPELDRPDVP 797

  Fly   359 LGLRGKKYDLFGNIEQIAEFHRDEFLPMLQRNRRDLKRLFDEFLQFLDQHCFYGYVIFTMNKQKS 423
            .||||::..||||:|::.:||.:.||..|:...|...|:...||:...|  |..|.:::.||.:|
Mouse   798 QGLRGQRAHLFGNLEKLRDFHYNFFLRELEACTRHPPRVAHAFLRHRVQ--FGMYALYSKNKPRS 860

  Fly   424 LKLCDLY-KNYFTSIRLERDDKLGINSFLVQPIQRMARYPLLLTQFINTFFKNRDIVMKPLIESC 487
            ..|...| ..:|...:....|.|.:.|:|::|||.|::|.|||.:               |..:|
Mouse   861 DALMTNYGHTFFKEKQQALGDHLDLASYLLKPIQHMSKYALLLQE---------------LARAC 910

  Fly   488 CRLEKRLRAL----------LTTTNESEIINDIVDCHEFNVYYQGKFRKVNEFQVL--DHKLKRS 540
            ....:.|.||          |...|:...::.|..| :.|:..||:..:.:||.|.  .||..|
Mouse   911 GGPAQELGALQAAQSLVHFQLRHGNDLLAMDAIQGC-DVNLKEQGQLVRQDEFTVRAGRHKACR- 973

  Fly   541 YRSKVFIFDKCIIYTEIK----GKNLLFHGR-YPCEHIGIS----AKTKSFTLYYERRKQQEC-- 594
               :||:|::.:::::.:    |.::..:.| :....:|::    .....|.:::.|||.::.
Mouse   974 ---RVFLFEELLLFSKPRRGPAGVDIFTYKRSFKMADLGLTECCGESQLRFEIWFRRRKARDLFV 1035

  Fly   595 ----------EFTADPVQIAIWLDLIRDMINN 616
                      .:||| :...:|    |..::|
Mouse  1036 LQASDVATKQAWTAD-ISRLLW----RQAVHN 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	52/143 (36%)
		ROM1	<438..>660	CDD:227709	46/212 (22%)
Plekhg4	XP_006530585.2	SEC14	230..351	CDD:214706
		COG4913	<446..>618	CDD:443941	11/45 (24%)
		RhoGEF	762..928	CDD:238091	57/182 (31%)
		PH_puratrophin-1	928..1063	CDD:270062	29/145 (20%)