Protein Alignment CG46491 and Plekhg2

DIOPT Version :10

• Sequence 1: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: XP_006539499.1
• Gene: Plekhg2 / 101497
• MGIID: 2141874
• Length: 1366
• Species: Mus musculus
• Alignment Length: 329
• Identity: 66/329 - (20%)
• Similarity: 125/329 - (37%)
• Gaps: 97/329 - (29%)

  Fly   326 ILEELIKTEEAYVNNLFTGIENY-GNIFQRKDLPLGLRGKKYDLFGNIEQIAEFHRDEFLPMLQR 389
            :..|:::||.|||.:|.:.:|:| |.:...:.|.|.:. :...||.|||.|.||.
Mouse   103 VAREIVETERAYVRDLRSIVEDYLGPLMDGRALGLNME-QVGTLFANIEDIYEFS---------- 156

  Fly   390 NRRDLKRLFDEFLQFLD--------QHCFYGYVIFTMNKQKSLKLCDLY-KNYFTSIRLERD--- 442
                     .|.|:.|:        ..||       :.:.:...:..|| .||.:|:.|.|:
Mouse   157 ---------SELLEDLEGCSSAGGIAECF-------VQRSEDFDIYTLYCMNYPSSLALLRELSV 205

  Fly   443 ----------------DKLGINSFLVQPIQRMARYPLLLTQFINTFFKNRDIVMKPLIESCCRLE 491
                            ..|.:.|||::|:||:.:|.|||.:....:.:..|...:.::|
Mouse   206 SPPATLWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPDSGGREMVE------ 264

  Fly   492 KRLRALLTTTNESEIINDIVDCHEFNVYYQGKFRKVNEFQ----------VLDHKLK-------- 538
               .|:::.|..:..|||:....|.....|...|::..:.          ||:...:
Mouse   265 ---EAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGTFRGGGGGGPR 326

  Fly   539 -RSYRSKVFIFDKCIIYTEIKGKNLLFHGRYPCEHIGISA--------KTKSFTL-----YYERR 589
             |.....:|:|.:.::..:.:|....:.|...|.::.:|.        |....|:     .::.:
Mouse   327 LRGGERLLFLFSRMLLVAKRRGPEYTYKGHIFCCNLSVSETPRDPLGFKVSDLTIPKHRHLFQAK 391

  Fly   590 KQQE 593
            .|:|
Mouse   392 NQEE 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	43/171 (25%)
		ROM1	<438..>660	CDD:227709	36/207 (17%)
Plekhg2	XP_006539499.1	RhoGEF	103..278	CDD:459876	47/210 (22%)
		PH_PLEKHG1_G2_G3	260..410	CDD:270063	22/145 (15%)
		PTZ00449	<351..742	CDD:185628	7/45 (16%)