Protein Alignment CG30456 and arhgef40

DIOPT Version :9

• Sequence 1: NP_611188.3
• Gene: CG30456 / 36929
• FlyBaseID: FBgn0050456
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: XP_001919604.4
• Gene: arhgef40 / 100151026
• ZFINID: ZDB-GENE-110623-2
• Length: 1752
• Species: Danio rerio
• Alignment Length: 670
• Identity: 130/670 - (19%)
• Similarity: 209/670 - (31%)
• Gaps: 225/670 - (33%)

  Fly     6 LSPLPFRRER------NLSNRNFNKRNSRRRISHQAAEQERHSSTLVSSNLESNDVARPVSSV-- 62
            |..||..||:      .||:|.....|::|.:|  ...:......:|||:..|:....|:||:
Zfish  1042 LEKLPPVREKVRDMSHCLSDRWTQLDNTQRLLS--TLTEASQWCDVVSSSSPSSSSTSPLSSLPP 1104

  Fly    63 -------SSSSSSIQLSYSVNSD-----------TDSSYRHRSLLKMHEAESV--------GGLG 101
                   .:.:.::.|......|           |.:.::.| :|:.....||        ||.|
Zfish  1105 IPPSRFQDARALALDLGGGALLDLWSQTLERYQKTLAEFKSR-ILQAERGSSVAQGQEPDLGGRG 1168

  Fly   102 TESTPESPMSPQTPDPALLDVRQKVH----------------RFEAFRTNICF---IKQERHSL- 146
            ....|.|..|       |.|:..::.                ....||...|.   |.:|:...
Zfish  1169 RTPAPSSTSS-------LGDLEGEIEPDWCPGGEGGMQSWGSLASLFRPQNCSTLKIGEEKKKEG 1226

  Fly   147 ------KLLENRRHPSFEDQSEDHHTPPATPPRRIRLPGLGSRGSSRSSSIPSF---------QA 196
                  |.|:|..||:.::.: |...|| .|||:..               |||         :|
Zfish  1227 VNPGGGKFLQNLLHPAKKNPT-DAPLPP-KPPRKRH---------------PSFDLQALLAPRRA 1274

  Fly   197 GIHEVRSEDEVDQISDFETDSHTAAEEYLVVDTTSEVVP------------------------SE 237
            |.....:|....|.|........|..:.::....:..||                        |:
Zfish  1275 GATSKPTESTSGQSSPLSWLGRKAMTDPILTAGVAAAVPGWRDPAAGGEAGGGGVLIRGVEVSSK 1339

  Fly   238 EVAD-SKVDQQQVQRSISADQSKEALTLPLKMRNDFPRNYRSTPRRKTEIIGTTNEHLVGKFHSV 301
            |||| :...:|.|..|                     |..|.|...:..:...:..:|
Zfish  1340 EVADHTGFTRQHVLLS---------------------RTERGTGLERAGVTAQSKLYL------- 1376

  Fly   302 YQPKDEEEEVEIELRDKSDKCVHPILEELIKTEEAYVNNLFTGIENYGNIFQRKDLPLGLRGKKY 366
                              ..|      .|:.||..||..|....|||..:.:..|:|..||||..
Zfish  1377 ------------------QWC------RLVSTERQYVAVLKGVEENYLPLLESPDVPSALRGKAE 1417

  Fly   367 DLFGNIEQIAEFHRDEFLPMLQRNRRDLKRLFDEFLQFLDQHCFYGYVIFTMNKQKSLKLCDLYK 431
            .||.|.:.::.||....||.::.......:..|.|.::.||...|...| .|..:....:.....
Zfish  1418 SLFCNWKSLSAFHSQLLLPAMEGALSQTLQQTDCFTKYKDQFLLYSQYI-RMRPETDALIISQAA 1481

  Fly   432 NYFTSIRLERDDKLGINSFLV----------QPIQRMARYPLLLTQFINTFFKNRDIVMKPLIES 486
            ::|         |:.:.|.||          .|:||:.:|...|.:...         :.|..:|
Zfish  1482 DFF---------KMKLCSSLVPAPPFPQCLSAPLQRLQQYTQALEELAG---------LNPGSDS 1528

  Fly   487 CCRLEKRLRALLTTTNESEIIN----------DIVDCHEFNVYYQGKFRKVNEFQVLDHKLKRSY 541
            ...:.|...........||:|:          |:|...|..|...|:.:|...
Zfish  1529 ALSIIKHAHRHGEDLRASELISGCPIPVAERGDLVRQGELCVCGGGRRKKTGV------------ 1581

  Fly   542 RSKVFIFDKCIIYTEIKGKN 561
             ..||::...:|:|:.|..|
Zfish  1582 -RNVFLYQNFMIFTKHKTPN 1600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30456	NP_611188.3	RhoGEF	326..470	CDD:279015	39/153 (25%)
arhgef40	XP_001919604.4	RhoGEF	1381..1519	CDD:295373	39/147 (27%)
		PH-like	1534..1673	CDD:302622	16/80 (20%)
		PH	1562..1661	CDD:278594	11/52 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810