Protein Alignment CG46491 and mcf2l2

DIOPT Version :10

• Sequence 1: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: XP_073772492.1
• Gene: mcf2l2 / 100149630
• ZFINID: ZDB-GENE-100812-1
• Length: 1284
• Species: Danio rerio
• Alignment Length: 788
• Identity: 174/788 - (22%)
• Similarity: 287/788 - (36%)
• Gaps: 230/788 - (29%)

  Fly    31 ISHQAAEQERHSSTLVSSNLES-NDVARPVSSVSSSSSSIQLSYSVNSDTDSSYRHRSLLKMHEA 94
            |..||.:.|.|  .|....:|: ..|.|.::.:..:.::.:..:|         ||.  ||:.:.
Zfish   295 IKDQATKAESH--ILNPDEVENQTTVERLLAQLDETENAFEQFWS---------RHH--LKLEQC 346

  Fly    95 ESVGGLGTESTPESPMSPQTPDPALLDVRQKVHRFEAFRTNICFIKQER--HSLKLLENRRHPSF 157
            ..:... .:...|..:|......|||.:..         |..|..:.|:  ..||.||::.....
Zfish   347 LQLRHF-EQDFKEVKVSLDGLSEALLGLSD---------TGDCVARVEQLLGELKTLEDKAQECL 401

  Fly   158 E---------DQ--SEDHHTPPATPPRRIRLPGLGSRGSSRSSSIPS-FQAGIHEVRSEDEVDQ- 209
            |         ||  ..:|:...:..|:.:.|..:....|:.:..... ....:..::..|||:|
Zfish   402 EKAQLQAQHGDQLIQSNHYAIDSIRPKCVELRRICDDFSNEAKKKRDVLTKSLEILKRIDEVNQW 466

  Fly   210 -------------------------ISDFETDSHTAAEEYL----VVDTTSEVVPSEEVADSKV- 244
                                     :.|.|....||.|:.|    .::...|||.| |:..|||
Zfish   467 CESGVYLLASQAVDRCQTQEGAEAALQDIERYMKTAKEQQLSHLKELNNQYEVVLS-ELLKSKVQ 530

  Fly   245 -------DQQQV-------QRSISADQSKEALTL-------PLKMRNDFPRNYRSTPRRKTEIIG 288
                   |.|::       .:.:|..|::....:       |.:.....|.....|..|||....
Zfish   531 TALKTLNDVQEMFEKRHASLKKLSTKQTRPVQPVAPRPESSPKRPSPKIPHPTPPTSHRKTTDNS 595

  Fly   289 TTNEHLVGKFHSVYQPKDEE-----------EEVEIELRDK-------------------SDKCV 323
            :||.          ||.|.|           ..::||:..:                   |::..
Zfish   596 STNR----------QPSDAELAKRKNIRKAKGGIKIEVMHEGGQGGSSHILMNNETEESLSNRRS 650

  Fly   324 HPILEELIKTEEAYVNNLFTGIENYGNIFQRKDL----PLGLRGKKYDLFGNIEQIAEFHRDEFL 384
            | |:.|||:||..||..|.:.||.|.......:|    |..|..||..||||:.:|.:||:..||
Zfish   651 H-IMNELIETERLYVEELQSIIEGYAAALDDPELIYLIPPSLENKKEVLFGNLPEIYQFHQKIFL 714

  Fly   385 PMLQRNRRD--------LKRLFDEFLQFLDQHCFYGYVIFTMNKQKSLKL---CDLYKNYFTSIR 438
            ..|:.:...        |||  .|.||..:::|        .||.:|..|   |. ...:|...:
Zfish   715 KELENSAEKPELVGTCFLKR--KEELQIYEKYC--------QNKPRSEALWRQCG-DSMFFQECQ 768

  Fly   439 LERDDKLGINSFLVQPIQRMARYPLLLTQFINTFFKNRDIVMKPLIESCCRLEKRLRALLTTTNE 503
            ...|.||.::::|::|:||:.:|.|:|.:.:.. .||.        |....||:   |..|..:.
Zfish   769 KRLDHKLSLDAYLLKPVQRITKYQLMLKEMLKC-SKNP--------EGTAELEE---AQATVLDI 821

  Fly   504 SEIIND-----IVDCHEFNVYYQGKFRKVNEFQV-LDH-----KLKRSYRSK-----VFIFDKCI 552
            .:.:||     .:...|.::...||......|.| .||     |:|...|.|     :|::.|.|
Zfish   822 IKSVNDSMHQIAITGFEGSLNDLGKLLMQGSFNVWTDHKKGHSKVKDLARFKPMQRHLFLYHKMI 886

  Fly   553 IYTEIKGKNLLFHGR---YPCEH------IGISAKT----KSFTLYYERRKQQECEFTADPVQIA 604
            ::.:.:.:....|.:   |..:|      :||:...    |.|.::|..|  :|......|..
Zfish   887 LFCKKREEMTDGHEKSPSYSFKHSLKMGSVGITENVKGDIKKFEIWYNGR--EEVYIIQAPSM-- 947

  Fly   605 IWLDLIRDMINNYANEERQKL--QERYSRENDHLHRK-------APSFSLYRDSNRFS------- 653
                   |:.|.:.:|.|:.|  |....||...||:|       ||..::.:.:.|.|
Zfish   948 -------DVKNTWVSEIRKVLTSQLEACREASQLHQKITENIYHAPMRNMRKTALRQSDSSSPET 1005

  Fly   654 ----SDSG 657
                ||||
Zfish  1006 GYRRSDSG 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	50/157 (32%)
		ROM1	<438..>660	CDD:227709	63/269 (23%)
mcf2l2	XP_073772492.1	None