Protein Alignment CG46491 and plekhg4b

DIOPT Version :10

• Sequence 1: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: XP_073780503.1
• Gene: plekhg4b / 100009641
• ZFINID: ZDB-GENE-101112-5
• Length: 1612
• Species: Danio rerio
• Alignment Length: 793
• Identity: 182/793 - (22%)
• Similarity: 303/793 - (38%)
• Gaps: 210/793 - (26%)

  Fly    12 RRERNLSNRNFNKRNSRRRISHQAAEQERHSSTLVSS----NLES-----------NDVAR---- 57
            |:|....|.|:..........:...::|.|...::|:    |||:           .::.|
Zfish   716 RKEEMCENHNYRDAVDLVSALYNQVDEEVHKLVILSNKSLQNLETLLELRTIQEKQEEIKRWFYV 780

  Fly    58 -------PVSSVSSSSSSIQLSYSVNSDTDSSYRHRSL-LKMHEAESVGGLGTESTPESPMSPQT 114
                   |:.|.|.|.||||         |.|   :|| |.|.||.......:....||..|
Zfish   781 ESERHLAPLDSFSLSLSSIQ---------DMS---KSLELFMQEAREQQNKASVLLRESDSS--- 830

  Fly   115 PDPALLDVRQKV----HRFEAFRTNICFIKQERHSLKLLEN--RRHPSFED---QSEDHHTPPAT 170
              .:||::.|::    .|.|.          .|..|.:|.|  ..:.|..:   |.:::..
Zfish   831 --SSLLELNQQIISVLQRCET----------RRSQLHVLHNLYEFYQSANEWMLQCQEYLC---- 879

  Fly   171 PPRRIRLPG----------LGSRGSSRS-SSIPSFQAGIHEVRS-----------------EDEV 207
               |:|:.|          ..|.....| .:..|||..:.::.|                 :.::
Zfish   880 ---RLRVDGDAAALQMLQDFHSEAQQFSPQNFSSFQQTLQQLESPGEEQRWRNIWRSCKHTQQQL 941

  Fly   208 DQISDFETDSHT-----AAEEYLVVDTTSEVVPSEEVADSKVDQQQVQRSIS-ADQSKEALTLPL 266
            :::.:..|..||     :..|.|....:.::.|.....:.. |..|..||:| |:.:....|:..
Zfish   942 EELMESSTPQHTTQVFSSPPESLNGGVSPDLPPLSSCVEYD-DAPQFPRSLSTAEDTDSDCTVDS 1005

  Fly   267 KMRNDFPRNYRSTPRRKTEIIGTTNEHLVGKFH---SVY----------------QPKDEEEEVE 312
            ....  |...|..|.:|   |..|..:.....|   .||                |..|.:..|.
Zfish  1006 SPSE--PHRLRKQPLKK---IMKTLSYEPSAHHGYTGVYIRGLEVSNNVSAEKKLQRPDVKSPVL 1065

  Fly   313 IELRDKSDKC-----------VHPILEELIKTEEAYVNNLFTGIENYGNIFQRKDLPLGLRGKKY 366
            ...|..|..|           |..|::|:|.||..||.:|...::.|....:|.|||..||||:.
Zfish  1066 TRSRSLSTPCRADHCHSVSSKVQHIMDEMISTEREYVRSLIYVVQQYFPEMERLDLPQDLRGKRS 1130

  Fly   367 DLFGNIEQIAEFHRDEFLPMLQRNRRDLKRLFDEFLQFLDQHCFYGYVIFTMNKQKSLKLCDLYK 431
            .:|||:|::::||...||..|:|.......:...||...:|  |..|.:::.||.:|..|...:.
Zfish  1131 IIFGNLEKLSDFHSLYFLKELERCSHSPLTVSRCFLMHEEQ--FGMYALYSKNKPRSDALLTSHG 1193

  Fly   432 N-YFTSIRLERDDKLGINSFLVQPIQRMARYPLLLTQFINTFFKNRDIVMKPLIESCCRLEKRLR 495
            | :|.:.::|..||:.:.|:|::|||||::|.|||               |.||:.|...:::..
Zfish  1194 NAFFRNKQVELGDKMDLASYLLKPIQRMSKYALLL---------------KDLIKECSESQEQEL 1243

  Fly   496 ALLTTTNESEII-----NDIV------DCHEFNVYYQGKFRKVNEFQVLDHKLKRSYRSKVFIFD 549
            |.|.|..|....     ||::      .| :.|:..||:.|..:||.|...:.|  |...||:|:
Zfish  1244 ADLRTAEEMVKFQLRHGNDLLAMDAIRGC-DVNLKEQGQLRCQDEFIVWCGRKK--YLRHVFLFE 1305

  Fly   550 KCIIYTEIK----GKNL-LFHGRYPCEHIGISAKTKS----FTLYYERRKQQECEF--TADPVQI 603
            ..|::::.|    |.:: ::...:....||::.....    |.:::.|||.|:...  .|.....
Zfish  1306 DLILFSKTKKIEGGYDIYIYKQSFKTAEIGMTESVGDSGLRFEIWFRRRKTQDTFILQAASAEVK 1370

  Fly   604 AIWLDLIRDMINNYANEERQ-KLQERYSRENDHLHRKAPSFSLYRDSNRFSSDSGIGNIWIMP-K 666
            ::|..:|..::...|...|: ::||..|                         .||||...|. |
Zfish  1371 SVWTGVIGKILWRQALRNRELRMQEMVS-------------------------MGIGNKPFMDIK 1410

  Fly   667 ADEDTISNRTTWY 679
            ..:..||:|...|
Zfish  1411 PSDSAISDRAVDY 1423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	52/143 (36%)
		ROM1	<438..>660	CDD:227709	57/244 (23%)
plekhg4b	XP_073780503.1	None