DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6967 and HELZ

DIOPT Version :9

Sequence 1:	NP_611185.3	Gene:	CG6967 / 36922	FlyBaseID:	FBgn0034187	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_006722277.1	Gene:	HELZ / 9931	HGNCID:	16878	Length:	1970	Species:	Homo sapiens

Alignment Length:	865	Identity:	201/865 - (23%)
Similarity:	334/865 - (38%)	Gaps:	236/865 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EANTNQDLSAN-----------NSVFGDFMKTKRLEFYNVCSVMQTLLTIDDLSNMELYAQ---- 64
            |.|...||..:           :.:|...:..|.|...|..|.:..||.|::::..:..:.
Human   417 EPNETTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISNTSGA 481

  Fly    65 -----LIQSDVPVQR----VSKL-----------TYKIT-----------------FKSTPVNAE 92
                 |:|....|.|    .|||           ::.:|                 ||.|...:|
Human   482 STSRILLQDTTNVTRGFSCCSKLFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSE 546

  Fly    93 DFVAPNLDQVVLVPKASLLASPLPKQLVLALLPHPHEDLEPGDPMLRHVASVDKVSSTTVHVRFS 157
            |.:|..|   |:....::...|:|||.::.         ..|.....:.|::::.:...:.:|.|
Human   547 DTLAGRL---VMTKVNAVYLLPVPKQKLVQ---------TQGTKEKVYEATIEEKTKEYIFLRLS 599

  Fly   158 RKHKAVLS-----GQRFYAIIRSRRLTIRYMYRALNLLQESPLVRRYLFPFPSWLTQLVDNSQIK 217
            |:....|:     ..:.....:..||.:..|:.||:.::::.:    |||..| :|..:.
Human   600 RECCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGV----LFPDIS-MTPTIP----- 654

  Fly   218 VCCDGHLPNWMQGRPQEPATPTSLSLLNSTIYSNAEQLEAVQRIVAGPSTQ-GPYILFGPPGTGK 281
                     |...|..:......|         ||:|.|||..|....:.| .|.::.||.||||
Human   655 ---------WSPNRQWDEQLDPRL---------NAKQKEAVLAITTPLAIQLPPVLIIGPYGTGK 701

  Fly   282 TTTIVEAILQLRLQQPQSRILVTAGSNSACDTIALK--LCEYIESNIRLQEHFAQQKLPEPDHQL 344
            |.|:.:|:..:..||..||||:...||||.| :.:|  |..|:|:.             .|..:.
Human   702 TFTLAQAVKHILQQQETSRILICTHSNSAAD-LYIKDYLHPYVEAG-------------NPQARP 752

  Fly   345 IRVYSRSIYEKGFASV--PSLLLKNSNCSKSIYDHIKASRIVKYGIIVATLCTVARLVTDTLGRY 407
            :|||.|:.:.|....|  ...|:.:::   |.:...:...|:|:.::|.||.|...|....| ..
Human   753 LRVYFRNRWVKTVHPVVHQYCLISSAH---STFQMPQKEDILKHRVVVVTLNTSQYLCQLDL-EP 813

  Fly   408 NFFTHIFIDEAGASTEPEALIGIMGIKQTADCHVILSGDHKQLGAVIKSNRAASLGLSRSLMERL 472
            .|||||.:|||..:.|.|.::.:  ...|.:..::|:|||.||...:.|..|....|..||::||
Human   814 GFFTHILLDEAAQAMECETIMPL--ALATQNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRL 876

  Fly   473 LQSDCYKSDENGNYDRNRQMR--LCRNYRSHPQIVRLFNELYYNGELKA--QAPAMDVNLAANWS 533
            .:          :|......|  ||.|||||..|:...:||:|.|:|.|  :.||
Human   877 YE----------HYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPA---------- 921

  Fly   534 VLTNPQFPIIFQATHGVTNREQNSTSSYNNLEAEVICWYVKRLINDRVV--GQED---VGIVAPY 593
              ....:|:.|....|...:|:|||:.|||.|...:...|:.|.....|  |:.|   :|:|.||
Human   922 --HKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPY 984

  Fly   594 TAQGKLVTKLLQSKGYPNVEVGSVETYQGREKTIIIASLVKS----------------------- 635
            ..|...:...|:.|...:|.|..|...||::..::..|.|::
Human   985 ADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTE 1049

  Fly   636 FTNMGFMCNPRRVNVLLSRAKALLILVGNPVTLRHHSDFKFVINECKK---------------HG 685
            ..:.||:.|.:.:|..::||::|:.:||:|:.|       ..|..|:|               ||
Human  1050 DLDYGFLSNYKLLNTAITRAQSLVAVVGDPIAL-------CSIGRCRKFWERFIALCHENSSLHG 1107

  Fly   686 -----------------TYLLKKRDSGQRPHILIKADESNEESSSEPEDEDDKLIPSYARMQQHT 733
                             ||:|    :...|..:.:|.......|:..:.:.    |...:...||
Human  1108 ITFEQIKAQLEALELKKTYVL----NPLAPEFIPRALRLQHSGSTNKQQQS----PPKGKSLHHT 1164

  Fly   734 DAAIHKIKAHPTNENDQLAN 753
                         :||...|
Human  1165 -------------QNDHFQN 1171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6967	NP_611185.3	AAA_11	251..456	CDD:289831	67/209 (32%)
		AAA_19	256..323	CDD:289986	29/69 (42%)
		UvrD_C_2	464..665	CDD:304668	62/232 (27%)
HELZ	XP_006722277.1	zf-CCCH	181..205	CDD:279036
		AAA_11	669..861	CDD:289831	68/220 (31%)
		P-loop_NTPase	669..>766	CDD:304359	40/119 (34%)
		DNA2	<785..1099	CDD:224037	94/345 (27%)
		UvrD_C_2	868..1079	CDD:304668	62/232 (27%)
		PHA03160	<1656..1815	CDD:165431
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D286011at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820