DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6967 and DNA2

DIOPT Version :9

Sequence 1:	NP_611185.3	Gene:	CG6967 / 36922	FlyBaseID:	FBgn0034187	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_012034.1	Gene:	DNA2 / 856569	SGDID:	S000001207	Length:	1522	Species:	Saccharomyces cerevisiae

Alignment Length:	786	Identity:	195/786 - (24%)
Similarity:	326/786 - (41%)	Gaps:	207/786 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NEMIEANTNQD--------------LSANNSVFGDFMKTKRLEFYNVCSVMQTLLTIDDLS---- 57
            |:::|..|.::              ||.|.:.:.:|. ||    ||      .|:|.::.|
Yeast   781 NKLLEDGTPEESGLVEGEFEILTNHLSQNLANYKEFF-TK----YN------DLITKEESSITCV 834

  Fly    58 NMELY---------------AQLIQSDVPVQRVSKLTYKITFK------------STPVNAEDFV 95
            |.||:               :.|:.|:|.....::..|...|.            |:.:.|.|||
Yeast   835 NKELFLLDGSTRESRSGRCLSGLVVSEVVEHEKTEGAYIYCFSRRRNDNNSQSMLSSQIAANDFV 899

  Fly    96 APNLDQ---------VVLVPKASLLASPLPKQLVLALLPHPHEDLEPGDPMLRHVASVDKVSSTT 151
            ..:.::         |..:..|.:..|...|.|...||     |.|.|...::.|...:...|
Yeast   900 IISDEEGHFCLCQGRVQFINPAKIGISVKRKLLNNRLL-----DKEKGVTTIQSVVESELEQS-- 957

  Fly   152 VHVRFSRKHKAVLSGQRFYAIIRSRRLTIRYMYRA-LNLLQESPLVRRY----LF-PFPSWLTQL 210
                               ::|.::.|.   .||. .|.:|:|..:.|:    || |..|....:
Yeast   958 -------------------SLIATQNLV---TYRIDKNDIQQSLSLARFNLLSLFLPAVSPGVDI 1000

  Fly   211 VDNSQIKVC-----------------CDGHLPNWMQGRPQEPATPTSLSLLNSTIYSNAEQLEAV 258
            || .:.|:|                 .|...|.:.... .:|..|..|| .::|:  |..|.||:
Yeast  1001 VD-ERSKLCRKTKRSDGGNEILRSLLVDNRAPKFRDAN-DDPVIPYKLS-KDTTL--NLNQKEAI 1060

  Fly   259 QRIVAGPSTQGPYILFGPPGTGKTTTIVEAILQLRLQQPQSRILVTAGSNSACDTIALKLCEYIE 323
            .:::   ..:...::.|.|||||||.|.| |:::.:.:.: |:|:|:.::||.|.|.:||   ..
Yeast  1061 DKVM---RAEDYALILGMPGTGKTTVIAE-IIKILVSEGK-RVLLTSYTHSAVDNILIKL---RN 1117

  Fly   324 SNIRLQEHFAQQKLPEPDHQLIRVYSRSIYEKGFASVPSLLLKNSNCSKSIYDHIKASRIVKYGI 388
            :||.:.....:.|: .||.|.        |...:|||           ||..|::..   :....
Yeast  1118 TNISIMRLGMKHKV-HPDTQK--------YVPNYASV-----------KSYNDYLSK---INSTS 1159

  Fly   389 IVATLCTVARLVTDTLGRYNFFTHIFIDEAGASTEPEALIGIMGIKQTADCHVILSGDHKQLGAV 453
            :|||.|.....:..||...: |.::.:|||...:.|.||    |..:..: ..|:.|||.||..:
Yeast  1160 VVATTCLGINDILFTLNEKD-FDYVILDEASQISMPVAL----GPLRYGN-RFIMVGDHYQLPPL 1218

  Fly   454 IKSNRAASLGLSRSLMERLLQSDCYKSDENGNYDRNRQMRLCRNYRSHPQIVRLFNELYYNGELK 518
            :| |.||.||   .|.|.|.::.|.|..|:       ...|...||....||.|.|.|.|:.:||
Yeast  1219 VK-NDAARLG---GLEESLFKTFCEKHPES-------VAELTLQYRMCGDIVTLSNFLIYDNKLK 1272

  Fly   519 -------AQAPAMDV--------NLAAN---W-SVLTNPQFPIIF----QATHGVTNREQNSTSS 560
                   ||:..:.:        |.:||   | ..:..|...::|    .....:...|:::.:
Yeast  1273 CGNNEVFAQSLELPMPEALSRYRNESANSKQWLEDILEPTRKVVFLNYDNCPDIIEQSEKDNIT- 1336

  Fly   561 YNNLEAEVICWYVKRLINDRVVGQEDVGIVAPYTAQGKLVTKLLQSKGYPNVEVGSVETYQGREK 625
             |:.|||:....|:.::... |..||:|::..|.||.:|:.|:.....|..:|:.:.:.:|||:|
Yeast  1337 -NHGEAELTLQCVEGMLLSG-VPCEDIGVMTLYRAQLRLLKKIFNKNVYDGLEILTADQFQGRDK 1399

  Fly   626 TIIIASLVK--SFTNMGFMCNP-RRVNVLLSRAKALLILVGNPVTLRHHSDFKFVINECKKHGTY 687
            ..||.|:|:  |..|.|.:... |||||.::|||:.||::|:..|:....:.|..:|
Yeast  1400 KCIIISMVRRNSQLNGGALLKELRRVNVAMTRAKSKLIIIGSKSTIGSVPEIKSFVN-------- 1456

  Fly   688 LLKKRD 693
            ||::|:
Yeast  1457 LLEERN 1462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6967	NP_611185.3	AAA_11	251..456	CDD:289831	57/204 (28%)
		AAA_19	256..323	CDD:289986	22/66 (33%)
		UvrD_C_2	464..665	CDD:304668	64/226 (28%)
DNA2	NP_012034.1	DNA2	551..1481	CDD:224037	195/786 (25%)
DNA2	NP_012034.1	DEXXQc_DNA2	1052..1253	CDD:350799	70/250 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810