Protein Alignment Mov10 and NAM7

DIOPT Version :10

• Sequence 1: NP_611185.3
• Gene: Mov10 / 36922
• FlyBaseID: FBgn0034187
• Length: 764
• Species: Drosophila melanogaster
• Sequence 2: NP_013797.1
• Gene: NAM7 / 855104
• SGDID: S000004685
• Length: 971
• Species: Saccharomyces cerevisiae
• Alignment Length: 615
• Identity: 163/615 - (26%)
• Similarity: 255/615 - (41%)
• Gaps: 148/615 - (24%)

  Fly   124 LPHPHED-----LEPG-DPMLRHV------------ASVDKVSSTTVHVRFSRKHKAVLSGQRFY 170
            ||:..:|     |:|. .|...|:            .|.|::..........:|.   :||..:|
Yeast   320 LPNSFQDTFTLELKPSKTPPPTHLTTGFTAEFIWKGTSYDRMQDALKKFAIDKKS---ISGYLYY 381

  Fly   171 AIIRSRRLTIRYMYRALNLLQESPLVRRYLFPFPSWLTQLVDNSQIKVCCDGHLPNWMQGRPQEP 235
            .|:..:.:.|.:         :.||.:.:                       .:||:.|
Yeast   382 KILGHQVVDISF---------DVPLPKEF-----------------------SIPNFAQ------ 408

  Fly   236 ATPTSLSLLNSTIYSNAEQLEAVQRIVAGPSTQGPYILFGPPGTGKTTTIVEAILQLRLQQPQSR 300
                    |||:      |..||..::..|.:    ::.||||||||.|....:..|. :..:.|
Yeast   409 --------LNSS------QSNAVSHVLQRPLS----LIQGPPGTGKTVTSATIVYHLS-KIHKDR 454

  Fly   301 ILVTAGSNSACDTIALKLCEYIESNIRLQEHFAQQKLPEPDHQLIRVYSRSIYEKGFASVPSLLL 365
            |||.|.||.|.|.:|.||.:.....:||    ..:...:.:..:..:...::..:|.......||
Yeast   455 ILVCAPSNVAVDHLAAKLRDLGLKVVRL----TAKSREDVESSVSNLALHNLVGRGAKGELKNLL 515

  Fly   366 K--------NSNCSKSIYDHIK--ASRIVKYGIIVATLCTVA---RLVTDTLGRYNFFTHIFIDE 417
            |        :::.:|.....::  .:.|:....:|...|..|   ||.|.       |..:.|||
Yeast   516 KLKDEVGELSASDTKRFVKLVRKTEAEILNKADVVCCTCVGAGDKRLDTK-------FRTVLIDE 573

  Fly   418 AGASTEPEALIGIM-GIKQTADCHVILSGDHKQLGAVIKSNRAASLGLSRSLMERLLQSDCYKSD 481
            :..::|||.||.|: |.||     |||.|||:|||.||...:||..||.:||.|||:...
Yeast   574 STQASEPECLIPIVKGAKQ-----VILVGDHQQLGPVILERKAADAGLKQSLFERLISLG----- 628

  Fly   482 ENGNYDRNRQMRLCRNYRSHPQIVRLFNELYYNGELKAQAPAMDVNLAANWSVLTNPQF------ 540
                   :..:||...||.:|.:....:.::|.|.|:.       .:......:.|.:|
Yeast   629 -------HVPIRLEVQYRMNPYLSEFPSNMFYEGSLQN-------GVTIEQRTVPNSKFPWPIRG 679

  Fly   541 -PIIFQATHGVTNREQNSTSSYNNLEAEVICWYVKRLINDRVVGQEDVGIVAPYTAQGKLVTKLL 604
             |::|.|.:|......|.||..|.:||......:.:|..|. |..|.:|::.||..|...:.:.:
Yeast   680 IPMMFWANYGREEISANGTSFLNRIEAMNCERIITKLFRDG-VKPEQIGVITPYEGQRAYILQYM 743

  Fly   605 QSKG------YPNVEVGSVETYQGREKTIIIASLVKSFTN--MGFMCNPRRVNVLLSRAKALLIL 661
            |..|      |..|||.||:.:|||||..||.|.|::...  :||:.:|||:||.|:|||..|::
Yeast   744 QMNGSLDKDLYIKVEVASVDAFQGREKDYIILSCVRANEQQAIGFLRDPRRLNVGLTRAKYGLVI 808

  Fly   662 VGNP-----VTLRHHSDFKFVINECKKHGT 686
            :|||     .||.:|....|....|...||
Yeast   809 LGNPRSLARNTLWNHLLIHFREKGCLVEGT 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mov10	NP_611185.3	DEXXQc_Helz-like	251..499	CDD:350796	75/261 (29%)
		DNA2	<388..684	CDD:440729	104/319 (33%)
NAM7	NP_013797.1	UPF1_Zn_bind	61..208	CDD:401391
		UPF1_1B_dom	260..352	CDD:407973	7/31 (23%)
		TIGR00376	357..836	CDD:273041	154/574 (27%)
		DEXXQc_UPF1	408..639	CDD:350797	79/283 (28%)