Protein Alignment Mov10 and SEN1

DIOPT Version :10

• Sequence 1: NP_611185.3
• Gene: Mov10 / 36922
• FlyBaseID: FBgn0034187
• Length: 764
• Species: Drosophila melanogaster
• Sequence 2: NP_013534.3
• Gene: SEN1 / 851150
• SGDID: S000004422
• Length: 2231
• Species: Saccharomyces cerevisiae
• Alignment Length: 744
• Identity: 178/744 - (23%)
• Similarity: 289/744 - (38%)
• Gaps: 208/744 - (27%)

  Fly   119 LVLALLP--HPHEDLEPGD-PMLRH--VASVDKVSST-----TVHVRFSRKHKAVLSGQRFYAII 173
            :|:|.||  .|.:.|...| ...:|  :|.|..:.:|     .|.:|..|.|..
Yeast  1217 IVMAYLPDFRPDKRLSSDDFKKAQHTCLAKVRTLKNTKGGNVDVTLRIHRNHSF----------- 1270

  Fly   174 RSRRLTIRYMYRALNLLQESPLVRRYLFPFPSWLTQLVDNSQIKVCCDGHLPNWMQGRPQEPAT- 237
             |:.||:|.....:.::|.:.:.|.|     |.|..|.....:     |.:   :|.:|..|..
Yeast  1271 -SKFLTLRSEIYCVKVMQMTTIEREY-----STLEGLEYYDLV-----GQI---LQAKPSPPVNV 1321

  Fly   238 -PTSLSLLNSTIYSNAEQLEAVQRIVAGPSTQGPYILFGPPGTGKTTTIV--------------E 287
             ...:..:..:...|..|.||   ||...|.:|..::.||||||||.||:              .
Yeast  1322 DAAEIETVKKSYKLNTSQAEA---IVNSVSKEGFSLIQGPPGTGKTKTILGIIGYFLSTKNASSS 1383

  Fly   288 AILQLRLQQPQS---------RILVTAGSNSACDTIALKLCEYIES------------------- 324
            .::::.|::..|         :||:.|.||:|.|.|.|:|...:..
Yeast  1384 NVIKVPLEKNSSNTEQLLKKQKILICAPSNAAVDEICLRLKSGVYDKQGHQFKPQLVRVGRSDVV 1448

  Fly   325 NIRLQ----EHFAQQKLPE------PDHQLIRVYSRSI-----------YEKGFASVP------- 361
            |:.::    |....:::.|      .|.:|.|.::.::           .|.|....|
Yeast  1449 NVAIKDLTLEELVDKRIGERNYEIRTDPELERKFNNAVTKRRELRGKLDSESGNPESPMSTEDIS 1513

  Fly   362 SLLLKNSNCSKSI------YDHIKASRIVKY------------------GIIVATLCTVARLVTD 402
            .|.||....||.|      .|.::....|.|                  .||.:||...|..|..
Yeast  1514 KLQLKIRELSKIINELGRDRDEMREKNSVNYRNRDLDRRNAQAHILAVSDIICSTLSGSAHDVLA 1578

  Fly   403 TLGRYNFFTHIFIDEAGASTEPEALIGI-MGIKQTADCHVILSGDHKQLGAVIKSNRAASLGLSR 466
            |:|..  |..:.||||...||..::|.: .|.|:   |  |:.||..||...:.|..|::...::
Yeast  1579 TMGIK--FDTVIIDEACQCTELSSIIPLRYGGKR---C--IMVGDPNQLPPTVLSGAASNFKYNQ 1636

  Fly   467 SLMERL-LQSDCYKSDENGNYDRNRQMRLCRNYRSHPQIVRLFNELYYNGELKAQAPAMDVNLAA 530
            ||..|: ..|..|..|.              .||.||.|.:..:..:|.|.|| ..|.||:....
Yeast  1637 SLFVRMEKNSSPYLLDV--------------QYRMHPSISKFPSSEFYQGRLK-DGPGMDILNKR 1686

  Fly   531 NWSVLTNPQFPI-IFQATHGVTNREQNS-TSSYNNLE----AEVICWYVKRLINDRVVGQEDVGI 589
            .|..| .|..|. .|....|  .:|||: |.||.|:|    |..:..|:.|..::::.....:||
Yeast  1687 PWHQL-EPLAPYKFFDIISG--RQEQNAKTMSYTNMEEIRVAIELVDYLFRKFDNKIDFTGKIGI 1748

  Fly   590 VAPYTAQ------------GKLVTKLLQSKGYPNVEVGSVETYQGREKTIIIASLVK---SFTNM 639
            ::||..|            |.::.|        :::..:::.:||:||.||:.|.|:   :.:::
Yeast  1749 ISPYREQMQKMRKEFARYFGGMINK--------SIDFNTIDGFQGQEKEIILISCVRADDTKSSV 1805

  Fly   640 GFMCNPRRVNVLLSRAKALLILVGNPVTLRHHSDFKFVINECKKHGTYLLKKRDSGQRPHILIKA 704
            ||:.:.||:||.|:|||..:.::|:..:|.....::.:|.:.|...  .|....||       ..
Yeast  1806 GFLKDFRRMNVALTRAKTSIWVLGHQRSLAKSKLWRDLIEDAKDRS--CLAYACSG-------FL 1861

  Fly   705 DESNEESSS---------EPEDEDDKLIP 724
            |..|..:.|         ..|.|||..:|
Yeast  1862 DPRNNRAQSILRKFNVPVPSEQEDDYKLP 1890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mov10	NP_611185.3	DEXXQc_Helz-like	251..499	CDD:350796	80/343 (23%)
		DNA2	<388..684	CDD:440729	90/318 (28%)
SEN1	NP_013534.3	SEN1_N	106..859	CDD:432746
		1B_Sen1p-like	1179..1284	CDD:394816	19/78 (24%)
		DEXXQc_SETX	1335..1656	CDD:438712	80/344 (23%)
		AAA_12	1634..1830	CDD:463780	60/221 (27%)