DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6967 and SEN1

DIOPT Version :9

Sequence 1:	NP_611185.3	Gene:	CG6967 / 36922	FlyBaseID:	FBgn0034187	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_013534.3	Gene:	SEN1 / 851150	SGDID:	S000004422	Length:	2231	Species:	Saccharomyces cerevisiae

Alignment Length:	744	Identity:	178/744 - (23%)
Similarity:	289/744 - (38%)	Gaps:	208/744 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 LVLALLP--HPHEDLEPGD-PMLRH--VASVDKVSST-----TVHVRFSRKHKAVLSGQRFYAII 173
            :|:|.||  .|.:.|...| ...:|  :|.|..:.:|     .|.:|..|.|..
Yeast  1217 IVMAYLPDFRPDKRLSSDDFKKAQHTCLAKVRTLKNTKGGNVDVTLRIHRNHSF----------- 1270

  Fly   174 RSRRLTIRYMYRALNLLQESPLVRRYLFPFPSWLTQLVDNSQIKVCCDGHLPNWMQGRPQEPAT- 237
             |:.||:|.....:.::|.:.:.|.|     |.|..|.....:     |.:   :|.:|..|..
Yeast  1271 -SKFLTLRSEIYCVKVMQMTTIEREY-----STLEGLEYYDLV-----GQI---LQAKPSPPVNV 1321

  Fly   238 -PTSLSLLNSTIYSNAEQLEAVQRIVAGPSTQGPYILFGPPGTGKTTTIV--------------E 287
             ...:..:..:...|..|.||   ||...|.:|..::.||||||||.||:              .
Yeast  1322 DAAEIETVKKSYKLNTSQAEA---IVNSVSKEGFSLIQGPPGTGKTKTILGIIGYFLSTKNASSS 1383

  Fly   288 AILQLRLQQPQS---------RILVTAGSNSACDTIALKLCEYIES------------------- 324
            .::::.|::..|         :||:.|.||:|.|.|.|:|...:..
Yeast  1384 NVIKVPLEKNSSNTEQLLKKQKILICAPSNAAVDEICLRLKSGVYDKQGHQFKPQLVRVGRSDVV 1448

  Fly   325 NIRLQ----EHFAQQKLPE------PDHQLIRVYSRSI-----------YEKGFASVP------- 361
            |:.::    |....:::.|      .|.:|.|.::.::           .|.|....|
Yeast  1449 NVAIKDLTLEELVDKRIGERNYEIRTDPELERKFNNAVTKRRELRGKLDSESGNPESPMSTEDIS 1513

  Fly   362 SLLLKNSNCSKSI------YDHIKASRIVKY------------------GIIVATLCTVARLVTD 402
            .|.||....||.|      .|.::....|.|                  .||.:||...|..|..
Yeast  1514 KLQLKIRELSKIINELGRDRDEMREKNSVNYRNRDLDRRNAQAHILAVSDIICSTLSGSAHDVLA 1578

  Fly   403 TLGRYNFFTHIFIDEAGASTEPEALIGI-MGIKQTADCHVILSGDHKQLGAVIKSNRAASLGLSR 466
            |:|..  |..:.||||...||..::|.: .|.|:   |  |:.||..||...:.|..|::...::
Yeast  1579 TMGIK--FDTVIIDEACQCTELSSIIPLRYGGKR---C--IMVGDPNQLPPTVLSGAASNFKYNQ 1636

  Fly   467 SLMERL-LQSDCYKSDENGNYDRNRQMRLCRNYRSHPQIVRLFNELYYNGELKAQAPAMDVNLAA 530
            ||..|: ..|..|..|.              .||.||.|.:..:..:|.|.|| ..|.||:....
Yeast  1637 SLFVRMEKNSSPYLLDV--------------QYRMHPSISKFPSSEFYQGRLK-DGPGMDILNKR 1686

  Fly   531 NWSVLTNPQFPI-IFQATHGVTNREQNS-TSSYNNLE----AEVICWYVKRLINDRVVGQEDVGI 589
            .|..| .|..|. .|....|  .:|||: |.||.|:|    |..:..|:.|..::::.....:||
Yeast  1687 PWHQL-EPLAPYKFFDIISG--RQEQNAKTMSYTNMEEIRVAIELVDYLFRKFDNKIDFTGKIGI 1748

  Fly   590 VAPYTAQ------------GKLVTKLLQSKGYPNVEVGSVETYQGREKTIIIASLVK---SFTNM 639
            ::||..|            |.::.|        :::..:::.:||:||.||:.|.|:   :.:::
Yeast  1749 ISPYREQMQKMRKEFARYFGGMINK--------SIDFNTIDGFQGQEKEIILISCVRADDTKSSV 1805

  Fly   640 GFMCNPRRVNVLLSRAKALLILVGNPVTLRHHSDFKFVINECKKHGTYLLKKRDSGQRPHILIKA 704
            ||:.:.||:||.|:|||..:.::|:..:|.....::.:|.:.|...  .|....||       ..
Yeast  1806 GFLKDFRRMNVALTRAKTSIWVLGHQRSLAKSKLWRDLIEDAKDRS--CLAYACSG-------FL 1861

  Fly   705 DESNEESSS---------EPEDEDDKLIP 724
            |..|..:.|         ..|.|||..:|
Yeast  1862 DPRNNRAQSILRKFNVPVPSEQEDDYKLP 1890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6967	NP_611185.3	AAA_11	251..456	CDD:289831	72/299 (24%)
		AAA_19	256..323	CDD:289986	28/89 (31%)
		UvrD_C_2	464..665	CDD:304668	61/222 (27%)
SEN1	NP_013534.3	SEN1_N	106..859	CDD:403815
SEN1	NP_013534.3	DNA2	1006..1858	CDD:224037	168/703 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341571
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740