DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6967 and dna2

DIOPT Version :9

Sequence 1:	NP_611185.3	Gene:	CG6967 / 36922	FlyBaseID:	FBgn0034187	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_021329958.1	Gene:	dna2 / 559535	ZFINID:	ZDB-GENE-090313-71	Length:	1374	Species:	Danio rerio

Alignment Length:	500	Identity:	138/500 - (27%)
Similarity:	220/500 - (44%)	Gaps:	99/500 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 GHLPNWMQGRPQ---------EPATPTSLSLLNSTIYSNAEQLEAVQRIVAG---PSTQG----- 269
            |:|...|:..|.         |...|..:..|:|.:..:|:.:  |..|:.|   |..|.
Zfish   894 GNLSMLMENTPTSERLRELIVEFRPPQFIDSLSSVLPRDAKDI--VSNILKGLNKPQKQAMKKVL 956

  Fly   270 ---PY-ILFGPPGTGKTTTIVEAILQLRLQQPQSRILVTAGSNSACDTIALKLCEYIESNIRLQE 330
               .| ::.|.|||||||||  ..|...|......:|:|:.::||.|.|.|||..:....:||..
Zfish   957 LSKDYTLIVGMPGTGKTTTI--CTLVRILHACGFSVLLTSYTHSAVDNILLKLKRFKIGFLRLGR 1019

  Fly   331 HFAQQKLPEPDHQLIRVYSRSIYEKGFASVPSLLLKNSNCSKSIYDHIKASRIVKYGIIVATLCT 395
               .||:   .|:::.....:...||..::..|        :.:|..         .:||||.|.
Zfish  1020 ---PQKV---HHEILPFTEEACRAKGIQTLEEL--------EQLYSR---------ELIVATTCM 1061

  Fly   396 VARLVTDTLGRYNFFTHIFIDEAGASTEPEALIGIMGIKQTADCHVILSGDHKQLGAVIKSNRAA 460
            ..:....:..|::|   ..:|||...::| ..||.:...|    ..:|.|||:||..::::..|.
Zfish  1062 GVKHPIFSRRRFDF---CIVDEASQISQP-VCIGPLFYAQ----RFVLVGDHQQLPPIVQNAEAR 1118

  Fly   461 SLGLSRSLMERLLQSDCYKSDENGNYDRNRQMRLCRNYRSHPQIVRLFNELYYNGEL-------- 517
            |||:..||.:||            .:.|:..::|...||.:..|:.|.|.|.|.|.|
Zfish  1119 SLGMDESLFKRL------------EHHRDAVVQLNVQYRMNSAIMSLSNALMYEGRLECGSEKTA 1171

  Fly   518 --------KAQAP------AMDVNLAANWSVLTNPQFPIIFQATHGVTNREQNSTSSY-NNLEAE 567
                    :|||.      ......:|.......|..|:.|..|..|...|....|.. |:.||.
Zfish  1172 NAVLQLPSRAQAEEELELYVCQPQYSAWVQAALEPNSPVCFLDTSEVPAPETVEKSGISNHTEAV 1236

  Fly   568 VICWYVKRLINDRVVGQE--DVGIVAPYTAQGKLVTKLLQSKGYPNVEVGSVETYQGREKTIIIA 630
            ::...|..|:.   .|..  |:|::|||..|.|:::.|||...:..:||.:|:.||||:|::||.
Zfish  1237 LVQGLVTLLLK---AGCRACDIGVIAPYRQQLKVISSLLQGDAFKALEVNTVDKYQGRDKSVIIV 1298

  Fly   631 SLVKSFT--NMGFMCNP-RRVNVLLSRAKALLILVGNPVTLRHHS 672
            |.|:|..  |:|.:... ||:||.::|||..|:::|:..|||.::
Zfish  1299 SFVRSNAEGNLGELLQDWRRLNVAITRAKHKLLMLGSAPTLRRYA 1343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6967	NP_611185.3	AAA_11	251..456	CDD:289831	57/216 (26%)
		AAA_19	256..323	CDD:289986	27/78 (35%)
		UvrD_C_2	464..665	CDD:304668	66/228 (29%)
dna2	XP_021329958.1	Dna2	391..602	CDD:312281
		Cas4_I-A_I-B_I-C_I-D_II-B	<579..721	CDD:321087
		AAA_11	788..1354	CDD:331082	138/499 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910