DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6967 and mov10b.2

DIOPT Version :9

Sequence 1:	NP_611185.3	Gene:	CG6967 / 36922	FlyBaseID:	FBgn0034187	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001037805.1	Gene:	mov10b.2 / 555950	ZFINID:	ZDB-GENE-060526-371	Length:	1015	Species:	Danio rerio

Alignment Length:	772	Identity:	236/772 - (30%)
Similarity:	365/772 - (47%)	Gaps:	142/772 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YYPPSNEMIEAN-TNQDLSANNSVFGDFMKTKRLEFYNVCSVMQTLLTIDDLS---NMELYAQLI 66
            |.||.:..|.|. ..:|.|:.  :|..  |.|.|:     |::|:.||.|:.:   ::.||.:..
Zfish   328 YIPPPDTTILAELLKEDCSSR--IFRG--KLKDLQ-----SLLQSPLTFDNYAERFDLLLYLEEC 383

  Fly    67 QSDVPVQRVSKLTYKITFKSTPVNAEDFVAPNLDQVVLVPKASLLASPLPKQLVLALLPHPHEDL 131
            |..|.::|.:|               |.|..:.|:              .|:|:...||...|:
Zfish   384 QMHVDIKRYNK---------------DSVTLHRDR--------------DKRLMGLNLPGVSEN- 418

  Fly   132 EP----GDPML-------------RHVASVDKVSSTTVHVRFSRK--HKAVLSGQRFYAIIRSRR 177
            .|    ||.:|             ::...|.:|....|.:..|::  ....:...:|.......|
Zfish   419 RPSVLRGDHLLLTKSEEVTFSNVTKYKGYVHRVELDQVKLGLSKRFLKDVYIDKMKFRVEFTVNR 483

  Fly   178 LTIRYMYRALNLLQESPLVRRYLFPFPSWLTQLVDNSQIKVCCDGHLPNWMQGRPQEPATPTSLS 242
            :.:|..:||:::..:..| :..|||                         |..|...|.:|.:|.
Zfish   484 IPVRLQHRAVHMAVQHNL-KDVLFP-------------------------MASRSLNPVSPPALR 522

  Fly   243 LLNSTIYSNAEQLEAVQRIVAGPSTQGPYILFGPPGTGKTTTIVEAILQLRLQQPQSRILVTAGS 307
            |.:..:..|.:|..||..||||.|...||::|||||||||.||||||.|:....|.:.||..|.|
Zfish   523 LFDRKLEYNFQQYSAVCNIVAGTSKPAPYLVFGPPGTGKTVTIVEAIKQVEKNIPDAYILACAPS 587

  Fly   308 NSACDTIALKLCEYIESNIRLQEHFAQQKLPEPDHQLIRVYSRSIYEKGFASVPSLLLKNSNCSK 372
            |||.|    :|||.:.::    ||.       ..|::.|:|:.|..:|   .:|.:|..|.|..:
Zfish   588 NSAAD----QLCEKLITS----EHV-------DAHKIYRLYASSRNQK---DIPKILKDNCNVDE 634

  Fly   373 SIYDHIKASRIVKYGIIVATLCTVARLVTDTLGRYNFFTHIFIDEAGASTEPEALIGIMGIKQTA 437
            .:.|......::.|.|::.||.|..||||..... :.|||.|:||||.:.|.|.:|.:.|:....
Zfish   635 EMIDFPCKEDLMSYKILICTLVTAGRLVTGGFSE-DHFTHNFVDEAGHAVESETIISVAGLLNAE 698

  Fly   438 DCHVILSGDHKQLGAVIKSNRAASLGLSRSLMERLL-QSDCYKSDENGNYDRNRQMRLCRNYRSH 501
            ...::|:||.||||.:::|..|.:.||..||:|||: |:|.||..: ..:|.....:|..|||||
Zfish   699 KGQLVLAGDPKQLGPILRSPLAINHGLDVSLLERLMTQNDLYKRGD-VEFDNRYVSKLIMNYRSH 762

  Fly   502 PQIVRLFNELYYNGELKAQAPAMDVNLAANWSVLTNPQFPIIFQATHGVTNREQNSTSSYNNLEA 566
            |.|:.:.|.|:|:|||||.|..:..|....|..|.:..||:||....|...||.||.|.:|..|.
Zfish   763 PYILEVPNRLFYDGELKACADEISSNQYCMWEHLPSKGFPVIFHGVPGKDERESNSPSFFNIYEI 827

  Fly   567 EVICWYVKRLINDRV------VGQEDVGIVAPYTAQGKLVTKLLQS-------KGYPNVEVGSVE 618
            .::..|:|:|:..:.      :..:|:||:|||..|.:.:.:.:.:       .|..|::|||||
Zfish   828 NILVDYLKKLLLTQPKKGISRIFPKDIGIIAPYRKQVEKIKRAIDADKDFQDYMGIDNLKVGSVE 892

  Fly   619 TYQGREKTIIIASLVKSFT---------NMGFMCNPRRVNVLLSRAKALLILVGNPVTLRHHSDF 674
            .:||:|:.:|:.|.|:|..         |:||:.|.:|.||.::|||:|||:||||:.||....:
Zfish   893 EFQGQERKVIMVSTVRSSVKYISLDETFNIGFLKNEKRFNVAVTRAKSLLIMVGNPMILRTDESW 957

  Fly   675 KFVINECKKHGTY-------LLKKRDSGQRPHILIKADESNEESS----SEPEDEDD 720
            ...|:.|.:.|.|       :.:..|...|...|...||..|||.    .:||..:|
Zfish   958 GRFIDFCLERGGYTGISITSVERIDDVESRLLALNIQDEETEESPVQRYVDPEFRND 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6967	NP_611185.3	AAA_11	251..456	CDD:289831	79/204 (39%)
		AAA_19	256..323	CDD:289986	37/66 (56%)
		UvrD_C_2	464..665	CDD:304668	82/223 (37%)
mov10b.2	NP_001037805.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..130
		MYCBPAP	<189..>262	CDD:291319
		AAA_11	552..718	CDD:289831	68/184 (37%)
		P-loop_NTPase	552..>714	CDD:304359	68/180 (38%)
		DNA2	<642..983	CDD:224037	121/342 (35%)
		DEAG box	677..680		2/2 (100%)
		AAA_12	725..948	CDD:289832	82/223 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I4307
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.780