Protein Alignment Mov10 and ZGRF1

DIOPT Version :10

• Sequence 1: NP_611185.3
• Gene: Mov10 / 36922
• FlyBaseID: FBgn0034187
• Length: 764
• Species: Drosophila melanogaster
• Sequence 2: NP_060862.3
• Gene: ZGRF1 / 55345
• HGNCID: 25654
• Length: 2104
• Species: Homo sapiens
• Alignment Length: 806
• Identity: 189/806 - (23%)
• Similarity: 310/806 - (38%)
• Gaps: 210/806 - (26%)

  Fly     2 RELPYYPPSNEMIEANTNQDLSANNSVFGDFMK--TKRLEFYNVCSVMQTLLTIDDLSNMELYAQ 64
            :::|.|    |..:....:........:|...|  |...||||   ..:|.|.: .||..|..:.
Human  1420 QKIPLY----EECQLLVRKGFDFQRKQYGKLKKFTTVNPEFYN---EPKTKLYL-KLSRKERSSA 1476

  Fly    65 LIQSDVPVQRVSK-LTYKITFKSTPVNAEDFVAP-NLDQVVLVPKASLLASPLPKQLV------- 120
            ..::|:.|  ||| |.:::   .|.:....|..| :::::.::|......|..|..:|
Human  1477 YSKNDLWV--VSKTLDFEL---DTFIACSAFFGPSSINEIEILPLKGYFPSNWPTNMVVHALLVC 1536

  Fly   121 -----LALLPHPHEDLEPGD-PMLRHVASVDKVSSTTVHVRFSRKHKAVLSGQRFYAIIRSRRLT 179
                 |..|.:..:...|.. |:.:::.:   .||.|: |...|..|.......|..:  |.:..
Human  1537 NASTELTTLKNIQDYFNPATLPLTQYLLT---TSSPTI-VSNKRVSKRKFIPPAFTNV--STKFE 1595

  Fly   180 IRYMYRALNLLQESPLVRRYLFPFPSWLTQLVDNSQIKVCCDGHLPNWMQGRPQEPATPTSLSLL 244
            :..:...|.|..|              |.|:            |..|..|.        |:|..:
Human  1596 LLSLGATLKLASE--------------LIQV------------HKLNKDQA--------TALIQI 1626

  Fly   245 NSTIYSNAEQLEAVQRIVAG--PSTQGPYILFGPPGTGKTTTIVEAIL---QL--RLQQPQS--- 299
            ...:.|: |.:|.|:.:...  |.|    |:.|..|.||:..:...||   ||  :.:.|..
Human  1627 AQMMASH-ESIEEVKELQTHTFPIT----IIHGVFGAGKSYLLAVVILFFVQLFEKSEAPTIGNA 1686

  Fly   300 ---RILVTAGSNSACDTIALKLCEY-IESNIRLQEHFAQQKLPEPD------------------- 341
               ::|:::.:|.|.|.:.|.|... .|:.||:.   :.:|:.:|.
Human  1687 RPWKLLISSSTNVAVDRVLLGLLSLGFENFIRVG---SVRKIAKPILPYSLHAGSENESEQLKEL 1748

  Fly   342 HQLI--------RVYSRSIYEKGFASVPSLLLKNSNCSKSIYDHIKASRIVKYGIIVATLCTVAR 398
            |.|:        |||.|                     |||..|       |.| ...||....|
Human  1749 HALMKEDLTPTERVYVR---------------------KSIEQH-------KLG-TNRTLLKQVR 1784

  Fly   399 LVTDTLGRYNF-------FTHIFIDEAGASTEPEALIGIMGIKQTADCH-VILSGDHKQLGAVIK 455
            :|..|.....|       |..:.:||....|||.:|:.|...    :|. :||.||.|||...|:
Human  1785 VVGVTCAACPFPCMNDLKFPVVVLDECSQITEPASLLPIARF----ECEKLILVGDPKQLPPTIQ 1845

  Fly   456 SNRAA-SLGLSRSLMERLLQSDCYKSDENGNYDRNRQMRLCRNYRSHPQIVRLFNELYYNGELKA 519
            .:.|| ..||.::|.:||    |...        ::.:.|...||.||.|..:.|:|:|.|.|..
Human  1846 GSDAAHENGLEQTLFDRL----CLMG--------HKPILLRTQYRCHPAISAIANDLFYKGALMN 1898

  Fly   520 QAPAMDVNLAANWSVLTNPQFP-IIFQATHGVTNREQNSTSSYNNLEAEVICWYVKRLINDRVVG 583
            ....::.:....|       .| :.|....|:...|::: |.:|..||......::.||...:.|
Human  1899 GVTEIERSPLLEW-------LPTLCFYNVKGLEQIERDN-SFHNVAEATFTLKLIQSLIASGIAG 1955

  Fly   584 QEDVGIVAPYTAQGKLVTKLLQSKGY-----PNVEVGSVETYQGREKTIIIASLVKSFTNMGFMC 643
            .. :|::..|.:|...:..||.:..:     ..|:|.:|:.:||.||.|||.|.|:: ..:||:.
Human  1956 SM-IGVITLYKSQMYKLCHLLSAVDFHHPDIKTVQVSTVDAFQGAEKEIIILSCVRT-RQVGFID 2018

  Fly   644 NPRRVNVLLSRAKALLILVGNPVTLRHHSDFKFVINECKKHGTYLLKKRDSG---------QRPH 699
            :.:|:||.|:|.|..|::|||...||.:..:..||..|        :.|:.|         |..|
Human  2019 SEKRMNVALTRGKRHLLIVGNLACLRKNQLWGRVIQHC--------EGREDGLQHANQYEPQLNH 2075

  Fly   700 IL----IKADESNEESSSEPEDEDDK 721
            :|    .|..|..::..||.|...||
Human  2076 LLKDYFEKQVEEKQKKKSEKEKSKDK 2101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mov10	NP_611185.3	DEXXQc_Helz-like	251..499	CDD:350796	70/297 (24%)
		DNA2	<388..684	CDD:440729	88/310 (28%)
ZGRF1	NP_060862.3	DUF2439	4..74	CDD:463065
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..359
		zf-GRF	1347..1391	CDD:462017
		DNA2	<1686..2057	CDD:440729	111/436 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2085..2104		6/17 (35%)