Protein Alignment Mov10 and MOV10L1

DIOPT Version :10

• Sequence 1: NP_611185.3
• Gene: Mov10 / 36922
• FlyBaseID: FBgn0034187
• Length: 764
• Species: Drosophila melanogaster
• Sequence 2: XP_011528998.1
• Gene: MOV10L1 / 54456
• HGNCID: 7201
• Length: 1256
• Species: Homo sapiens
• Alignment Length: 810
• Identity: 213/810 - (26%)
• Similarity: 327/810 - (40%)
• Gaps: 213/810 - (26%)

  Fly    53 IDDLSNMELYAQLIQSDVPVQRVSKLTYKITFKSTPVNAEDFVAP------NLDQVVLVPKASLL 111
            ||.|:...|.|:|:...         .||..| ||.:..|:..|.      |:..::|.....||
Human   512 IDILTFQPLLAELLNMS---------NYKEKF-STLLWLEEIYAEMELKEYNMSGIILRRNGDLL 566

  Fly   112 ASPLPKQLVLALLPHPHEDLEPGDPM-----------LRHVASVDKVSSTTVHVRFSRKHKAVLS 165
            ...:|.      |......|..||.:           :.:::.|.::....|.::.:.:.:...:
Human   567 VLEVPG------LAEGRPSLYAGDKLILKTQEYNGHAIEYISYVTEIHEEDVTLKINPEFEQAYN 625

  Fly   166 GQRFYAIIRSRRLTIRYMYRAL--------------NLLQESPLV-------------------- 196
            .:.........|.|.|..:.||              .::.:||.|
Human   626 FEPMDVEFTYNRTTSRRCHFALEHVIHLGVKVLFPEEIILQSPQVTGNWNHAQDTKSSGQSTSKK 690

  Fly   197 ---------------RR-------YLFPFPSWLTQLVDNSQIKVCCDGHLPNWMQGRPQEPATPT 239
                           ||       .|.||.:.::..||..|                     ||.
Human   691 NRKTMTDQAEHGTEERRVGDKDLPVLAPFTAEMSDWVDEIQ---------------------TPK 734

  Fly   240 S--LSLLNSTIYSNAEQLEAVQRIVAGPSTQGPYILFGPPGTGKTTTIVEAILQLRLQQPQSRIL 302
            :  :...|..:  |..|..||:||::|.....|||||||||||||.||:||:||:....|.||||
Human   735 ARKMEFFNPVL--NENQKLAVKRILSGDCRPLPYILFGPPGTGKTVTIIEAVLQVHFALPDSRIL 797

  Fly   303 VTAGSNSACDTIALKLCEYIESNIRLQEHFAQQKLPEPDHQLIRVYSRSIYEKGFASVPSLLLKN 367
            |.|.||||.|.:.|:|.|              .|:.:| ..::||.:...:|:..........::
Human   798 VCAPSNSAADLVCLRLHE--------------SKVLQP-ATMVRVNATCRFEEIVIDAVKPYCRD 847

  Fly   368 SNCSKSIYDHIKASRIVKYGIIVATLCTVARLVTDTLGRYNFFTHIFIDEAGASTEPEALIGIMG 432
            ..      |..||||   :.||:.| |:.:.|......|...|||:|:||||.::|||.||. :|
Human   848 GE------DIWKASR---FRIIITT-CSSSGLFYQIGVRVGHFTHVFVDEAGQASEPECLIP-LG 901

  Fly   433 IKQTADCHVILSGDHKQLGAVIKSNRAASLGLSRSLMERLLQSDCYKSDEN-----GNYDRNRQM 492
            :.......::|:||..|||.||||..|.:.||:.|.:|||:....|:.|||     |.::.....
Human   902 LMSDISGQIVLAGDPMQLGPVIKSRLAMAYGLNVSFLERLMSRPAYQRDENAFGACGAHNPLLVT 966

  Fly   493 RLCRNYRSHPQIVRLFNELYYNGELKAQAPAMDVNLAANWSVLTNPQFPIIFQATHGVTNREQNS 557
            :|.:|||||..::.|.:.|:|:.||:..|....|.....|..|....||:||....|...||..|
Human   967 KLVKNYRSHEALLMLPSRLFYHRELEVCADPTVVTSLLGWEKLPKKGFPLIFHGVRGSEAREGKS 1031

  Fly   558 TSSYNNLEAEVI---CWYVKRLINDRVVGQEDVGIVAPYTAQ----------------------- 596
            .|.:|..||..:   |..:...|:.: |...|:|::.||..|
Human  1032 PSWFNPAEAVQVLRYCCLLAHSISSQ-VSASDIGVITPYRKQWLWSSGGDTGASHAEHQVSFMKH 1095

  Fly   597 ------------GK----------LVTKLLQSKGYPNVEVGSVETYQGREKTIIIASLVKSFTN- 638
                        ||          .:..||::....:::|||||.:||:|..:||.|.|:|..:
Human  1096 VSLWCSHHQAELGKNPQNTEEKVEKIRILLRNVDLMDIKVGSVEEFQGQEYLVIIISTVRSNEDR 1160

  Fly   639 -------MGFMCNPRRVNVLLSRAKALLILVGNPVTLRHHSDFKFVINECKKHGTY--------L 688
                   :||:.|.:|.||.::|.|||||::|||..|.....|..::.....:|.|        |
Human  1161 FEDDRYFLGFLSNSKRFNVAITRPKALLIVLGNPHVLVRDPCFGALLEYSITNGVYMGCDLPPAL 1225

  Fly   689 LKKRDSGQ---RPHILIKADESNEESSSEP 715
            ...::.|:   .|...:..:.:..|...||
Human  1226 QSLQNCGEGVADPSYPVVPESTGPEKHQEP 1255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mov10	NP_611185.3	DEXXQc_Helz-like	251..499	CDD:350796	95/252 (38%)
		DNA2	<388..684	CDD:440729	111/356 (31%)
MOV10L1	XP_011528998.1	DEXXQc_Mov10L1	744..973	CDD:350836	95/256 (37%)
		SF1_C_Upf1	974..1209	CDD:350195	65/235 (28%)