DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6967 and upf1

DIOPT Version :9

Sequence 1:	NP_611185.3	Gene:	CG6967 / 36922	FlyBaseID:	FBgn0034187	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_998639.1	Gene:	upf1 / 406783	ZFINID:	ZDB-GENE-040426-2836	Length:	1100	Species:	Danio rerio

Alignment Length:	465	Identity:	140/465 - (30%)
Similarity:	211/465 - (45%)	Gaps:	74/465 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 NAEQLEAVQRIVAGPSTQGPYILFGPPGTGKTTTIVEAILQLRLQQPQSRILVTAGSNSACDTIA 315
            |..|:.||:.::..|.:    ::.||||||||.|....:..| .:|....:||.|.||.|.|.:.
Zfish   452 NHSQVYAVKTVLQRPLS----LIQGPPGTGKTVTSATIVYHL-ARQGNGPVLVCAPSNIAVDQLT 511

  Fly   316 LKLCEYIESNIRLQEHFAQQKLPEPD-----HQLIRVYSRSIYEKGFASVPSL----LLKN---- 367
            .|:.:.....:||... :::.:..|.     |..||         ...|:|.|    .||:
Zfish   512 EKIHQTGLKVVRLCAK-SREAIDSPVSFLALHNQIR---------NMDSMPELQKLQQLKDETGE 566

  Fly   368 -SNCSKSIYDHIK--ASR--IVKYGIIVATLCTVARLVTDTLGRYNFFTHIFIDEAGASTEPEAL 427
             |:..:..|..:|  |.|  ::...:|   .||........|.:.. |..|.|||:..:||||.:
Zfish   567 LSSSDEKRYRALKRTAERELLMNADVI---CCTCVGAGDPRLAKMQ-FRSILIDESTQATEPECM 627

  Fly   428 IG-IMGIKQTADCHVILSGDHKQLGAVIKSNRAASLGLSRSLMERLLQSDCYKSDENGNYDRNRQ 491
            :. ::|.||     :||.|||.|||.|:...:||..|||:||.|||:....            |.
Zfish   628 VPVVLGAKQ-----LILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGI------------RP 675

  Fly   492 MRLCRNYRSHPQIVRLFNELYYNGELKAQAPAMD---VNLAANWSVLTNPQFPIIFQATHGVTNR 553
            :||...||.||.:....:.::|.|.|:....|.|   ......|   ..|..|:.|..|.|....
Zfish   676 IRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRLKKGFDFQW---PQPDKPMFFYVTQGQEEI 737

  Fly   554 EQNSTSSYNNLEAEVICWYVKRLINDRVVG--QEDVGIVAPYTAQGKLVTKLLQSKG------YP 610
            ..:.||..|..||..:.....||:.   .|  .:.:||:.||..|...:.:.:|..|      |.
Zfish   738 ASSGTSYLNRTEAANVEKITTRLLK---AGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQ 799

  Fly   611 NVEVGSVETYQGREKTIIIASLVKS--FTNMGFMCNPRRVNVLLSRAKALLILVGNPVTLRHHSD 673
            .||:.||:.:|||||..||.|.|::  ...:||:.:|||:||.|:||:..:|:||||..|.....
Zfish   800 EVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPL 864

  Fly   674 FKFVINECKK 683
            :..::|..|:
Zfish   865 WNHLLNYYKE 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6967	NP_611185.3	AAA_11	251..456	CDD:289831	65/223 (29%)
		AAA_19	256..323	CDD:289986	22/66 (33%)
		UvrD_C_2	464..665	CDD:304668	67/213 (31%)
upf1	NP_998639.1	UPF1_Zn_bind	100..251	CDD:286500
		DNA2	124..889	CDD:224037	140/465 (30%)
		AAA_19	457..>514	CDD:289986	21/61 (34%)
		AAA_12	660..857	CDD:289832	68/214 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810