DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6967 and Setx

DIOPT Version :9

Sequence 1:	NP_611185.3	Gene:	CG6967 / 36922	FlyBaseID:	FBgn0034187	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_006233948.1	Gene:	Setx / 362096	RGDID:	1565575	Length:	2702	Species:	Rattus norvegicus

Alignment Length:	886	Identity:	192/886 - (21%)
Similarity:	320/886 - (36%)	Gaps:	257/886 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NEMIEANTNQD-LSANNSVFGDFMKTKRLEFYNVCSVMQTLLTIDDLSNMELYAQLIQSDVPVQR 74
            |....|.::.| |..:.|:|..|:|......|      |..|..|.........|.|...|||:.
  Rat  1661 NRPASAASSVDILLPSQSIFDTFIKEVLKWKY------QMFLNFDKCGAPTSLCQSISRPVPVRF 1719

  Fly    75 VSKLTYKITFKSTPV-NAEDFVA------PNLDQVVLVPKASLLA--------------SPLPKQ 118
            .....|...|....: ||.:.||      ||.:....:......|              |.|.||
  Rat  1720 QDCAEYFNVFLPLIILNAFETVAQEWLNSPNKENFYQLHLRKFPADYKKYWEFLIYLEESELAKQ 1784

  Fly   119 LVLALLPHPHED----LEPGDPMLRHVASVDKVSSTTVHVRFSRKHKAVLSG------------- 166
            |      ||.|:    |.|....:...:..|:......:|...|:...:.||
  Rat  1785 L------HPKENDLVFLVPEKKYMDRHSVQDRSHYYCGYVHKFRRTSVMRSGKTECSLCIQTQDN 1843

  Fly   167 ------QRFYAIIRSRRLTIRYMYRALNLLQ-ESPLVRRYLFPFPSWLTQLVDNSQIKVCCDGHL 224
                  :....|:.|..:|.:...:|::||. .:.|.|..|.|.|
  Rat  1844 MPASVKELTKCIVISSLVTTQRKLKAMSLLSGRNQLARAVLNPNP-------------------- 1888

  Fly   225 PNWMQGRPQEPATPTSLSLLNSTIYSNAEQLEAVQRIVA----GPSTQGPYILFGPPGTGKTTTI 285
               |....::..|.||..::......|.:|.:|::...|    .||.....::.|||||||:.||
  Rat  1889 ---MDFCTKDLLTTTSERIIAYLKDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTI 1950

  Fly   286 VEAILQLRLQQ--------------PQSRILVTAGSNSACDTIALKL-----------------C 319
            |..:.:|..:.              .|:|:||.|.||:|.|.:..|:                 |
  Rat  1951 VGLLYRLLTESQRKGHSDENFNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNC 2015

  Fly   320 EYI-------ESNIRLQ----------EHFAQQKLPEPDHQLIRVYSRSIYEKGFASVPSLLLKN 367
            ..|       |.:|..:          .|..::.||....:::|  .:.|.:   |.:..|..:.
  Rat  2016 GDINLVRLGPEKSINTEVLKFSLDSQVSHRMKKDLPSHIQEMLR--RKEILD---AQLDELSRQR 2075

  Fly   368 SNC-------SKSIYDHI---------KASR---------------IVKYGIIVATLCTVARLVT 401
            :.|       .:.:.:||         .||:               |::..:|..||.|...|:.
  Rat  2076 ALCRGGREMQRQELDEHIVIVSKERQELASKIKEVQGRPQRAQNTIILESHVICCTLSTSGGLLL 2140

  Fly   402 DTLGRYNF---FTHIFIDEAGASTEPEALIGIMGIKQTADCH-VILSGDHKQLGAVIKSNRAASL 462
            ::..|...   |:.:.:||||.|.|.|.|..::     ..|: ::|.||.|||...:.|.:|...
  Rat  2141 ESAFRGQGGVPFSCVIVDEAGQSCEVETLSPLI-----HRCNKLVLVGDPKQLPPTVISMKAQEY 2200

  Fly   463 GLSRSLMERLLQSDCYKSDENGNYD---RNRQMRLCRNYRSHPQIVRLFNELYYNGELKAQAPAM 524
            |..:|:|.|.    |...:||...:   |...::|...||.||.|....:...||..||......
  Rat  2201 GYDQSMMARF----CKLLEENVEQNMIGRLPVLQLTIQYRMHPDICLFPSNYVYNKNLKTNRLTE 2261

  Fly   525 DVNLAANWSVLTNPQFP-IIFQATHGVTNREQNSTSSYNNLEAEVICWYVKRLIND--RVVGQED 586
            .:..::.|     |..| ::|....|   .||....||.|::...:...:.:||.:  :.:...:
  Rat  2262 TIRCSSEW-----PFQPYLVFDVGDG---SEQRDNDSYINVQEIKLVMEIIKLIKEKRKDISFRN 2318

  Fly   587 VGIVAPYTAQGKLVTK----------LLQ------------------------------------ 605
            :||:..|.||..::.|          |||
  Rat  2319 IGIITHYKAQKTMIQKDLEKEFDKKGLLQPIMMGESRQQDSEASKQQQKSSECMHASDELDSSTV 2383

  Fly   606 -SKGYPNV----------EVGSVETYQGREKTIIIASLVKSFT---NMGFMCNPRRVNVLLSRAK 656
             ..|..::          ||.:|:.:|||:|..||.:.|::..   ::||:.:.:|:||.::|||
  Rat  2384 TQSGISSLENGATHTGPAEVDTVDAFQGRQKDCIIVTCVRASAVQGSIGFLASLQRLNVTITRAK 2448

  Fly   657 ALLILVGNPVTLRHHSDFKFVINECKKHGTYLLKKRDSGQR 697
            ..|.::|:..||..:..:..:|.:.:|.|. ::|..|...|
  Rat  2449 YSLFILGHLRTLMENQHWYELIQDAQKRGA-IIKTCDPNYR 2488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6967	NP_611185.3	AAA_11	251..456	CDD:289831	66/291 (23%)
		AAA_19	256..323	CDD:289986	27/108 (25%)
		UvrD_C_2	464..665	CDD:304668	59/266 (22%)
Setx	XP_006233948.1	SEN1_N	37..>356	CDD:289496
		AAA_11	1910..2195	CDD:289831	66/294 (22%)
		AAA_19	1934..>1997	CDD:289986	20/62 (32%)
		AAA_12	2202..2456	CDD:289832	58/265 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335122
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850