DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6967 and Dna2

DIOPT Version :9

Sequence 1:	NP_611185.3	Gene:	CG6967 / 36922	FlyBaseID:	FBgn0034187	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_796346.2	Gene:	Dna2 / 327762	MGIID:	2443732	Length:	1062	Species:	Mus musculus

Alignment Length:	734	Identity:	175/734 - (23%)
Similarity:	307/734 - (41%)	Gaps:	189/734 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 MKTKRLEFYNVCSVMQTL-------------LTIDDLSNME----LYAQLIQSDVPVQRVSKLTY 80
            ::...|:::::..:|.||             :.:...|.:|    ....|:::: ||.||....|
Mouse   434 LQLAHLKYFSLWCLMLTLESQSKDNRKTHQSIWLTPASELEESGNCVGNLVRTE-PVSRVCDGQY 497

  Fly    81 KITF--KSTPVNAEDFVAPNLDQVVLVPKASLLASPLPKQLVLALLPHPHEDLEPGDPMLRHVAS 143
            ...|  |:.|:.|.:.:|.  |:::|..:...|.:                 |..|     :|..
Mouse   498 LHNFQRKNGPMPATNLMAG--DRIILSGEERKLFA-----------------LSKG-----YVKK 538

  Fly   144 VDKVSSTTVHVRFSRKHKAVLSGQRFYAIIRSRR-----LTIRYMYRALNLLQESPLVRRYLFPF 203
            ::|.:.|.:..|    :.:.|.....:.:.|..|     ..:..:.:.:.....|..:|..:..|
Mouse   539 MNKAAVTCLLDR----NLSTLPATTVFRLDREERHGDISTPLGNLSKLMESTDPSKRLRELIIDF 599

  Fly   204 --PSWLTQLVDNSQIKVCCDGHLPNWMQGRPQEPATPTSLSLLNSTIYSNAEQLEAVQRIVAGPS 266
              |.::..|   |.:       ||:        .|..|..::|...   |..|.:|::|::.
Mouse   600 REPQFIAYL---SSV-------LPH--------DAKDTVANILKGL---NKPQRQAMKRVLL--- 640

  Fly   267 TQGPYILFGPPGTGKTTTIVEAILQLRLQQPQSRILVTAGSNSACDTIALKLCEYIESNIRL-QE 330
            ::...::.|.|||||||||. |:::: |......:|:|:.::||.|.|.|||.::....:|| |.
Mouse   641 SKDYTLIVGMPGTGKTTTIC-ALVRI-LSACGFSVLLTSYTHSAVDNILLKLAKFKVGFLRLGQS 703

  Fly   331 HFAQ---QKLPEPDHQLIRVYSRSIYEKGFASVPSL-LLKNSNCSKSIYDHIKASRIVKYGIIVA 391
            |...   ||..|  .::.|  ||||     ||:..| .|.||:                  .|||
Mouse   704 HKVHPDIQKFTE--EEICR--SRSI-----ASLAHLEELYNSH------------------PIVA 741

  Fly   392 TLCTVARLVTDTLGRYNFFTHIFIDEAGASTEPEALIGIMGIKQTADCHVILSGDHKQLGAVIKS 456
            |.|..   :...:.....|....:|||...::|..|..:...::     .:|.|||:||..::.:
Mouse   742 TTCMG---INHPIFSRKTFDFCIVDEASQISQPVCLGPLFFSRR-----FVLVGDHQQLPPLVVN 798

  Fly   457 NRAASLGLSRSLMERLLQSDCYKSDENGNYDRNRQ--MRLCRNYRSHPQIVRLFNELYYNGELKA 519
            ..|.:||:|.||.:||              :||..  ::|...||.:.:|:.|.|:|.|.|:|:.
Mouse   799 REARALGMSESLFKRL--------------ERNESAVVQLTVQYRMNRKIMSLSNKLTYAGKLEC 849

  Fly   520 ---------------QAPAMDVNLAANWS-------VLTNPQFPIIFQATHGVTNREQNSTSSYN 562
                           :...:.:.|.|::|       || .|..|:.|..|..|...||......:
Mouse   850 GSDRVANAVLALPNLKDARLSLQLYADYSDSPWLAGVL-EPDNPVCFLNTDKVPAPEQVENGGVS 913

  Fly   563 NL-EAEVICWYVKRLINDRVVGQEDVGIVAPYTAQGKLVTKLLQSKGYPNVEVGSVETYQGREKT 626
            |: ||.:|.:.....|. ......|:|::|||..|.::::.||.......|||.:|:.||||:|:
Mouse   914 NVTEARLIVFLTSTFIK-AGCSPSDIGVIAPYRQQLRIISDLLARSSVGMVEVNTVDKYQGRDKS 977

  Fly   627 IIIASLVKSFTN--MGFMCNP-RRVNVLLSRAKALLILVGNPVTL-------------------- 668
            :|:.|.|:|..:  :|.:... ||:||.|:|||..|||:|:..:|
Mouse   978 LILVSFVRSNEDGTLGELLKDWRRLNVALTRAKHKLILLGSVSSLKRFPPLGTLFDHLNAEQLIL 1042

  Fly   669 ----RHHSDFKFVINECKK 683
                |.|.....::.:|::
Mouse  1043 DLPSREHESLSHILGDCQR 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6967	NP_611185.3	AAA_11	251..456	CDD:289831	60/209 (29%)
		AAA_19	256..323	CDD:289986	23/66 (35%)
		UvrD_C_2	464..665	CDD:304668	68/228 (30%)
Dna2	NP_796346.2	Dna2	72..283	CDD:285859
		Nuclease activity. /evidence=ECO:0000250	82..520		18/88 (20%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<256..398	CDD:294426
		TIGR00376	472..1034	CDD:273041	167/667 (25%)
		Helicase activity. /evidence=ECO:0000250	521..1062		157/644 (24%)
		P-loop_NTPase	626..830	CDD:304359	72/260 (28%)
		AAA_12	806..1020	CDD:289832	68/229 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831391
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740