DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6967 and Upf1

DIOPT Version :9

Sequence 1:	NP_611185.3	Gene:	CG6967 / 36922	FlyBaseID:	FBgn0034187	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster

Alignment Length:	496	Identity:	146/496 - (29%)
Similarity:	227/496 - (45%)	Gaps:	67/496 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 NAEQLEAVQRIVAGPSTQGPYILFGPPGTGKTTTIVEAILQLRLQQPQSRILVTAGSNSACDTIA 315
            |..|:.||:..:..|.:    ::.||||||||.|....:.|| ::.....:||.|.||:|.|.:.
  Fly   453 NRSQVYAVKHALQRPLS----LIQGPPGTGKTVTSATIVYQL-VKLHGGTVLVCAPSNTAVDQLT 512

  Fly   316 LKLCEYIESNIRLQEHFAQQK--LPEPD-----HQLIRVYSRSIYEKGFASVPSLLLKNSNCSKS 373
            .|:   ..:|:::....|:.:  :..|.     |..||....:...|....:.....:.|:..:.
  Fly   513 EKI---HRTNLKVVRVCAKSREAIDSPVSFLALHNQIRNMETNSELKKLQQLKDETGELSSADEK 574

  Fly   374 IYDHIKASRIVKYGIIVAT---LCTVARLVTDTLGRYNFFTHIFIDEAGASTEPEALIG-IMGIK 434
            .|.::|  |..:..::.|.   .||........|.|.. ||.|.|||:..|||||.::. ::|.|
  Fly   575 RYRNLK--RAAENQLLEAADVICCTCVGAGDGRLSRVK-FTSILIDESMQSTEPECMVPVVLGAK 636

  Fly   435 QTADCHVILSGDHKQLGAVIKSNRAASLGLSRSLMERLLQSDCYKSDENGNYDRNRQMRLCRNYR 499
            |     :||.|||.|||.|:...:||..|||:||.|||:....            |..||...||
  Fly   637 Q-----LILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGI------------RPFRLEVQYR 684

  Fly   500 SHPQIVRLFNELYYNGELKAQAPAMDVNLAAN--WSVLTNPQFPIIFQATHGVTNREQNSTSSYN 562
            .||::.:..:..:|.|.|:....|.|..|..:  |   ..|:.|:.|..|.|......:.||..|
  Fly   685 MHPELSQFPSNFFYEGSLQNGVCAEDRRLKLDFPW---PQPERPMFFLVTQGQEEIAGSGTSFLN 746

  Fly   563 NLEAEVICWYVKRLINDRVVGQEDVGIVAPYTAQGKLVTKLLQSKG------YPNVEVGSVETYQ 621
            ..||..:.....|.:. ..:..|.:||:.||..|...:.:.:|.:|      |..:|:.||:.:|
  Fly   747 RTEAANVEKITTRFLK-AGIKPEQIGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQ 810

  Fly   622 GREKTIIIASLVKS--FTNMGFMCNPRRVNVLLSRAKALLILVGNPVTLRHHSDFKFVINECKKH 684
            ||||.|||.|.|:|  ...:||:.:|||:||.|:|||..:|:||||..|.....:..::|..|..
  Fly   811 GREKDIIIMSCVRSNERQGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKDR 875

  Fly   685 GTYLLKKRDSGQRPHILIKADESNEESSSEPEDEDDKLIPS 725
                          .:|::...:|.:.|.....:..||:.|
  Fly   876 --------------KVLVEGSLNNLKESLIHFQKPKKLVNS 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6967	NP_611185.3	AAA_11	251..456	CDD:289831	63/215 (29%)
		AAA_19	256..323	CDD:289986	22/66 (33%)
		UvrD_C_2	464..665	CDD:304668	69/210 (33%)
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500
		DNA2	122..897	CDD:224037	143/489 (29%)
		Mis12	210..299	CDD:283509
		AAA_19	458..>515	CDD:289986	21/61 (34%)
		AAA_12	661..857	CDD:289832	70/211 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438980
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D27889at6960
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10887
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850