DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6967 and Zgrf1

DIOPT Version :9

Sequence 1:	NP_611185.3	Gene:	CG6967 / 36922	FlyBaseID:	FBgn0034187	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_006233356.1	Gene:	Zgrf1 / 310880	RGDID:	1305834	Length:	2031	Species:	Rattus norvegicus

Alignment Length:	856	Identity:	186/856 - (21%)
Similarity:	328/856 - (38%)	Gaps:	250/856 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PPSNE-----MIEANTNQDLSAN----NSVF------GDFMKTKRLEFYNVCSV----------- 46
            |..|:     .:|..|.:.||.|    |.:|      |.:::::::..|..|.:
  Rat  1306 PKGNQCKFFKWLEDVTPEQLSQNESQPNMIFNDIKSIGSYLRSQKIAVYEECQLLLRKGFDFQKK 1370

  Fly    47 ----MQTLLTIDDLSNMELYAQLIQSDVPVQRVSKLTYKITFK---------------------- 85
                ::.|.|:    |.|.|:         :..|||..|::.|
  Rat  1371 QHGKLKKLATV----NPEFYS---------ETKSKLYLKLSRKESSSVYSKGDLWVISKTLDFEL 1422

  Fly    86 STPVNAEDFVAP-NLDQVVLVPKASLLASPLPKQLV------------LALLPHPHEDLEPGD-P 136
            .|.:....|..| ::::|.|:|......|..|..:.            |.:|.:..:...|.. |
  Rat  1423 DTFIACSAFFGPSSVNEVELLPLKGYFPSNWPTNITVHALLVCNVSTELTMLQNIQDYFNPATLP 1487

  Fly   137 MLRHVASVDKVSSTTVHVRFSRKHK----AVLSGQRFYAIIRSRRLTIRYMYRALNLLQESPLVR 197
            ::.::.::.:  |.||..:...|.|    |:.|.:..:.::        ::...|.|.:|...|.
  Rat  1488 LMPYLLAMSQ--SATVSSKNVSKRKFIPPAITSIKTKFELL--------HLGATLQLARELINVH 1542

  Fly   198 RYLFPFPSWLTQLVDNSQIKVCCDGHLPNWMQGRPQEPATPTSLSLLNSTIYSNAEQLEAVQRIV 262
            |......|.|.|:   :|:..         .:|..::...|.|.||
  Rat  1543 RLNNDQASALMQI---AQMMA---------SRGSDEDALEPFSHSL------------------- 1576

  Fly   263 AGPSTQGPYILFGPPGTGKTTTIVEAILQL--RLQQPQS---------RILVTAGSNSACDTIAL 316
              |.|    ::.|..|.||:..:...||.|  ..::..|         ::|:::.:|.|.|.:.|
  Rat  1577 --PIT----VIHGVFGAGKSYLLAVVILFLVELFEKCDSEAVGRARPWKLLISSSTNVAVDRVLL 1635

  Fly   317 KLCEY-IESNIRL--QEHFAQQKLPEPDH--------QLIRVYSRSIYEKGFASVPSLLLKNSNC 370
            .|... .|..||:  ....|:..||...|        ||..::  ::..:....:..:.::
  Rat  1636 GLLSLGFEKFIRVGSVRKIAKPVLPYSLHASSDNESEQLKELH--ALMREELTPIERVYVR---- 1694

  Fly   371 SKSIYDH-IKASRIVKYGIIVATLCTVARLVTDTLGRYNF-------FTHIFIDEAGASTEPEAL 427
             |||..| :..:|:         |...||:|..|.....|       |..:.:||....|||.:|
  Rat  1695 -KSIEQHKLGTNRV---------LLKQARVVGITCAACPFPCMNDLKFPVVVLDECSQMTEPASL 1749

  Fly   428 IGIMGIKQTADCH-VILSGDHKQLGAVIKSNRAA-SLGLSRSLMERLLQSDCYKSDENGNYDRNR 490
            :.|...    :|. :||.||.|||...|:.:.|| ..||.::|.:||    |...        ::
  Rat  1750 LPIARF----ECEKLILVGDPKQLPPTIQGSDAAHGNGLEQTLFDRL----CLMG--------HK 1798

  Fly   491 QMRLCRNYRSHPQIVRLFNELYYNGEL------KAQAPAMDVNLAANWSVLTNPQFPIIFQATHG 549
            .::|...||.||.|..:.|:|:|.|.|      :.::|.::      |       .|.:  ..:.
  Rat  1799 PIQLRTQYRCHPVISAIANDLFYEGNLVNGISERERSPVLE------W-------LPTL--CFYN 1848

  Fly   550 VTNREQ--NSTSSYNNLEAEVICWYVKRLINDRVVGQEDVGIVAPYTAQGKLVTKLLQS--KGYP 610
            ||..||  ...|..|..||......::.||...:.|.. :|::..|.:|...:..||.:  ..:|
  Rat  1849 VTGTEQVERENSFVNVAEAAFTLKLIRSLIASGLEGSM-IGVITLYKSQMYKICSLLSAVDVDHP 1912

  Fly   611 N---VEVGSVETYQGREKTIIIASLVKSFTNMGFMCNPRRVNVLLSRAKALLILVGNPVTLRHHS 672
            :   |||.:|:.:||.||.|||.|.|:: ..:||:.:.:|:||.|:|.:..|:::|:...||.:.
  Rat  1913 DVKAVEVSTVDAFQGAEKEIIILSCVRT-RQVGFIDSEKRMNVALTRGRRHLLIIGSLSCLRKNQ 1976

  Fly   673 DFKFVINECKKHGTYLLKKRDSGQRPHILIKADESNEESSSEPEDEDDKLIPSY-----ARMQQH 732
            .:..||..|                     |..|...:.:|:.|.:.|:|:..|     ...|:.
  Rat  1977 LWGRVIQHC---------------------KGREDGLQHASQCEPQLDRLLKEYLEKQAEEKQKK 2020

  Fly   733 TDAAIHKIKAH 743
            |:....|.|:|
  Rat  2021 TEKEKLKDKSH 2031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6967	NP_611185.3	AAA_11	251..456	CDD:289831	53/235 (23%)
		AAA_19	256..323	CDD:289986	16/78 (21%)
		UvrD_C_2	464..665	CDD:304668	58/213 (27%)
Zgrf1	XP_006233356.1	DUF2439	3..75	CDD:402138
		zf-GRF	1276..1320	CDD:399670	3/13 (23%)
		DEAD-like_helicase_N	1543..1807	CDD:421690	72/332 (22%)
		AAA_12	1784..1968	CDD:404073	57/212 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335127
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830