DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6967 and Helz

DIOPT Version :9

Sequence 1:	NP_611185.3	Gene:	CG6967 / 36922	FlyBaseID:	FBgn0034187	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_008766536.1	Gene:	Helz / 287773	RGDID:	1307049	Length:	1981	Species:	Rattus norvegicus

Alignment Length:	856	Identity:	213/856 - (24%)
Similarity:	346/856 - (40%)	Gaps:	213/856 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YPPSNEMI---EANTNQD------------LSANNSVFGDFMKTKRLEFYNVCSVMQTLLTIDDL 56
            :.||::.|   |.|...|            ||| :.:|...:..|.|...|..|.:..||.|:::
  Rat   406 WEPSSKTIVDFEPNETTDWEKSLLIRYQIPLSA-DQLFTQSVLDKSLTKTNYQSRLHDLLYIEEI 469

  Fly    57 SNMELYAQL--------------IQSDVPVQRVSKLTYKIT-----------------FKSTPVN 90
            :..:..::|              .:.::.||.....::.:|                 ||.|...
  Rat   470 AQYKEVSRLNGIEPVKVPICVHCAKFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETL 534

  Fly    91 AEDFVAPNL-----DQVVL--VPKASLLASPLPKQLVLALLPHPHEDLEPGDPMLRHVASVDKVS 148
            :||.:|..|     :.|.|  |||..|:.|...|:.|                   :.|::::.:
  Rat   535 SEDTLAGRLVMTRVNAVYLLPVPKEKLVQSQGTKEKV-------------------YEATIEEKT 580

  Fly   149 STTVHVRFSRKHKAVLS-----GQRFYAIIRSRRLTIRYMYRALNLLQESPLVRRYLFPFPSWLT 208
            ...|.:|.||:....||     ..:.....:..||.:..|:.||:.::::.:    |||..| :|
  Rat   581 KDYVFLRISRECCEELSLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGV----LFPDIS-MT 640

  Fly   209 QLVDNSQIKVCCDGHLPNWMQGRPQEPATPTSLSLLNSTIYSNAEQLEAVQRIVAGPSTQ-GPYI 272
            ..:.              |...|..:......|         ||:|.|||..|......| .|.:
  Rat   641 PTIP--------------WSPNRQWDEQLDPRL---------NAKQKEAVLAITTPLCIQLPPVL 682

  Fly   273 LFGPPGTGKTTTIVEAILQLRLQQPQSRILVTAGSNSACDTIALKLCEYIESNIRLQEHFAQQKL 337
            :.||.|||||.|:.:|:..:..||..||||:...||||.|   |.:.:|:...:   |....|..
  Rat   683 IIGPYGTGKTFTLAQAVKHILQQQETSRILICTHSNSAAD---LYIKDYLHPYV---EAGNAQAR 741

  Fly   338 PEPDHQLIRVYSRSIYEKGFASV--PSLLLKNSNCSKSIYDHIKASRIVKYGIIVATLCTVARLV 400
            |      :|||.|:.:.|....|  ...|:.:::   |.:...:...|:|:.::|.||.|...|.
  Rat   742 P------LRVYFRNRWVKTVHPVVHQYCLISSAH---STFQMPQKEDILKHRVVVVTLNTSQYLC 797

  Fly   401 TDTLGRYNFFTHIFIDEAGASTEPEALIGI-MGIKQTADCHVILSGDHKQLGAVIKSNRAASLGL 464
            ...| ...|||||.:|||..:.|.|.::.: :..|.|   .::|:|||.||...:.|..|....|
  Rat   798 QLDL-EPGFFTHILLDEAAQAMECETIMPLALATKNT---RIVLAGDHMQLSPFVYSEFARERNL 858

  Fly   465 SRSLMERLLQSDCYKSDENGNYDRNRQMR--LCRNYRSHPQIVRLFNELYYNGELKA--QAPAMD 525
            ..||::||.:          :|......|  ||.|||||..|:...:||:|.|:|.|  :.||
  Rat   859 HVSLLDRLYE----------HYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPA-- 911

  Fly   526 VNLAANWSVLTNPQFPIIFQATHGVTNREQNSTSSYNNLEAEVICWYVKRLINDRVV--GQED-- 586
                      ....:|:.|....|...:|:|||:.|||.|...:...|:.|.....|  |:.|
  Rat   912 ----------HKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDG 966

  Fly   587 -VGIVAPYTAQGKLVTKLLQSKGYPNVEVGSVETYQGREKTIIIASLVKS--------------- 635
             :|:|.||..|...:...|:.|...:|.|..|...||::..::..|.|::
  Rat   967 SIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKE 1031

  Fly   636 --------FTNMGFMCNPRRVNVLLSRAKALLILVGNPVTLRHHSDFKFVINECKKHGTYLLKKR 692
                    ..:.||:.|.:.:|..::||::|:.:||:||.|       ..|..|:|.....:...
  Rat  1032 QLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPVAL-------CSIGRCRKFWERFIALC 1089

  Fly   693 DSGQRPHIL----IKAD-ESNEESSS------EPEDEDDKLIPSYARMQQHTDAAIH-----KIK 741
            ......|.:    |||. |:.|...:      .||     .||...|:|...:::..     |:|
  Rat  1090 HENHSLHGITFEQIKAQLEALELKKTYVLNPLAPE-----FIPRAFRLQHSGNSSRQQQSPPKVK 1149

  Fly   742 A--HPTNENDQ 750
            :  ||.|::.|
  Rat  1150 SLHHPQNDHFQ 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6967	NP_611185.3	AAA_11	251..456	CDD:289831	68/208 (33%)
		AAA_19	256..323	CDD:289986	28/67 (42%)
		UvrD_C_2	464..665	CDD:304668	62/232 (27%)
Helz	XP_008766536.1	zf-CCCH	181..205	CDD:395517
		DEXXQc_HELZ	658..885	CDD:350835	81/264 (31%)
		SF1_C_Upf1	886..1086	CDD:350195	56/218 (26%)
		Atrophin-1	<1195..>1536	CDD:397323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D286011at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820