DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mov10 and SETX

DIOPT Version :10

Sequence 1:NP_611185.3 Gene:Mov10 / 36922 FlyBaseID:FBgn0034187 Length:764 Species:Drosophila melanogaster
Sequence 2:NP_001338457.1 Gene:SETX / 23064 HGNCID:445 Length:2706 Species:Homo sapiens


Alignment Length:885 Identity:203/885 - (22%)
Similarity:333/885 - (37%) Gaps:256/885 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 ELPYYPPSNEMIEANTNQDLSANNSVFGDFMKTKRLEFYNV--CSVMQTLLTIDDLSNMELYAQL 65
            |..|:|.|:.:....::|  |.:::...:.:|.|...|.|.  |....:|            .|.
Human  1678 ESKYFPSSSPVNILLSSQ--SVSDTFVKEVLKWKYEMFLNFGQCGPPASL------------CQS 1728

  Fly    66 IQSDVPVQRVSKLTY-KITFKSTPVNAEDFVA------PNLDQ-------------------VVL 104
            |...|||:..:...| .:.|....:|..:.||      ||.:.                   .|.
Human  1729 ISRPVPVRFHNYGDYFNVFFPLMVLNTFETVAQEWLNSPNRENFYQLQVRKFPADYIKYWEFAVY 1793

  Fly   105 VPKASLLASPLPKQLVLALLPHPHEDLEPGDPMLRHVASVDKVSSTTVHVRFSR-------KHKA 162
            :.:..|.....||:..|..|.....:.|..|.....:..:.:..|..|| :|.|       |.:.
Human  1794 LEECELAKQLYPKENDLVFLAPERINEEKKDTERNDIQDLHEYHSGYVH-KFRRTSVMRNGKTEC 1857

  Fly   163 VLSGQ---RFYA--------IIRSRRLTIRYMYRALNLL-QESPLVRRYLFPFPSWLTQLVDNSQ 215
            .||.|   .|.|        |:.|..:|.:...:|::|| ..:.|.|..|.|.|           
Human  1858 YLSIQTQENFPANLNELVNCIVISSLVTTQRKLKAMSLLGSRNQLARAVLNPNP----------- 1911

  Fly   216 IKVCCDGHLPNWMQGRPQEPATPTSLSLLNSTIYSNAEQLEAVQRIVA----GPSTQGPYILFGP 276
                        |....::..|.||..::......|.:|.:|::...|    .||.....::.||
Human  1912 ------------MDFCTKDLLTTTSERIIAYLRDFNEDQKKAIETAYAMVKHSPSVAKICLIHGP 1964

  Fly   277 PGTGKTTTIVEAILQLRLQQ--------------PQSRILVTAGSNSACDTIALKLCEYIESNIR 327
            |||||:.|||..:.:|..:.              .|:|:||.|.||:|.|.:..|:.      :.
Human  1965 PGTGKSKTIVGLLYRLLTENQRKGHSDENSNAKIKQNRVLVCAPSNAAVDELMKKII------LE 2023

  Fly   328 LQEHFAQQKLPE---PDHQLIRVYSRSIYEKGFASVPSLLLK-------NSNCSKSIYDHIKA-- 380
            .:|....:|.|.   .|..|:|:..    ||   |:.|.:||       |....|.:..|::|  
Human  2024 FKEKCKDKKNPLGNCGDINLVRLGP----EK---SINSEVLKFSLDSQVNHRMKKELPSHVQAMH 2081

  Fly   381 -------------SR------------------------------------------------IV 384
                         ||                                                |:
Human  2082 KRKEFLDYQLDELSRQRALCRGGREIQRQELDENISKVSKERQELASKIKEVQGRPQKTQSIIIL 2146

  Fly   385 KYGIIVATLCTVARLVTDTLGRYNF---FTHIFIDEAGASTEPEALIGIMGIKQTADCH-VILSG 445
            :..||..||.|...|:.::..|...   |:.:.:||||.|.|.|.|..::     ..|: :||.|
Human  2147 ESHIICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEIETLTPLI-----HRCNKLILVG 2206

  Fly   446 DHKQLGAVIKSNRAASLGLSRSLMERLLQSDCYKSDENGNYD---RNRQMRLCRNYRSHPQIVRL 507
            |.|||...:.|.:|...|..:|:|.|.    |...:||..::   |...::|...||.||.|...
Human  2207 DPKQLPPTVISMKAQEYGYDQSMMARF----CRLLEENVEHNMISRLPILQLTVQYRMHPDICLF 2267

  Fly   508 FNELYYNGELKAQAPAMDVNLAANWSVLTNPQFP-IIFQATHGVTNREQNSTSSYNNLEAEVICW 571
            .:...||..||.......:..:::|     |..| ::|....|   .|:....||.|::...:..
Human  2268 PSNYVYNRNLKTNRQTEAIRCSSDW-----PFQPYLVFDVGDG---SERRDNDSYINVQEIKLVM 2324

  Fly   572 YVKRLIND--RVVGQEDVGIVAPYTAQGKLVTKLLQS----KGYPNVEVGSVETYQGREKTIIIA 630
            .:.:||.|  :.|...::||:..|.||..::.|.|..    ||  ..||.:|:.:|||:|..:|.
Human  2325 EIIKLIKDKRKDVSFRNIGIITHYKAQKTMIQKDLDKEFDRKG--PAEVDTVDAFQGRQKDCVIV 2387

  Fly   631 SLVKSFT---NMGFMCNPRRVNVLLSRAKALLILVGNPVTLR-----------HHSDF-----KF 676
            :.|::.:   ::||:.:.:|:||.::|||..|.::|:..||.           :||.|     |:
Human  2388 TCVRANSIQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMQLLPRSFCVHVNHSPFFSPEPKY 2452

  Fly   677 -------------VINECKKHGTYLLKKRDSGQRPHILIK 703
                         :|.:.:|.|. ::|..|...| |..:|
Human  2453 LHWALKENQHWNQLIQDAQKRGA-IIKTCDKNYR-HDAVK 2490

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mov10NP_611185.3 DEXXQc_Helz-like 251..499 CDD:350796 81/345 (23%)
DNA2 <388..684 CDD:440729 92/341 (27%)
SETXNP_001338457.1 SEN1_N 37..>351 CDD:432746
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1158..1219
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1237..1258
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1351..1385
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1579..1604
DEXXQc_SETX 1934..2259 CDD:438712 81/346 (23%)
Bipartite nuclear localization signal. /evidence=ECO:0000255 2070..2087 3/16 (19%)
AAA_12 2225..2424 CDD:463780 57/212 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2503..2525
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2585..2606
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2626..2706
Necessary for nuclear localization 2690..2706
Blue background indicates that the domain is not in the aligned region.

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