DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6967 and C41D11.6

DIOPT Version :9

Sequence 1:	NP_611185.3	Gene:	CG6967 / 36922	FlyBaseID:	FBgn0034187	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_491376.1	Gene:	C41D11.6 / 183377	WormBaseID:	WBGene00016565	Length:	852	Species:	Caenorhabditis elegans

Alignment Length:	801	Identity:	141/801 - (17%)
Similarity:	236/801 - (29%)	Gaps:	325/801 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IEANTNQDLSANNSVFGDFMKTKR-----LEFYNVCSVM-------------QTLLTIDDLSNME 60
            :.||...||...|.....:..|.|     .::|...::|             ..:.|.|.:.||:
Worm   238 VVANDRPDLMYMNFTKWSYDVTSRKYAELKQYYKGDTIMIHKVVKRRDVAPESFMKTFDQIRNMK 302

  Fly    61 L--YAQLIQSDVPVQRVSK-----------------------LTYKITFKSTPVNAEDFVAP--- 97
            .  |.|:.:..:..:::|:                       :|..:|......|  |..||
Worm   303 AHNYWQVSEFSLVQRKISEPQPFSLVGRAAGGRHSKKLAVCGVTEIVTVSEDTFN--DNRAPQGY 365

  Fly    98 NLDQVVLVPKASLLASPLPKQLVLALLPHPHEDLEPGDPMLRHVASVDKVSSTTVHVRFSRKHKA 162
            ..|.|...|..      :|.||:.:||        ||.|                |:...|:..|
Worm   366 RADAVAFTPVL------IPGQLLKSLL--------PGTP----------------HIVVRRETAA 400

  Fly   163 VLSGQRFYAIIRSRRLTIRYMYRALNLLQESPLVRRYLFPFPSWLTQLVDNSQIKVCCDGHLPNW 227
                       :|:...:|     ..::....:..|..:||.                  ||||:
Worm   401 -----------QSKSWDLR-----PQVINFGIMGARKAYPFL------------------HLPNY 431

  Fly   228 MQGRPQEPATPTS-----------LSLLNSTIYSNAE------------QLEAVQRI---VAGP- 265
            |.||  .|.|..:           ||.:.||...|.:            :||...::   :..|
Worm   432 MAGR--SPNTEDAWRGVRKLGHHGLSAMISTSNMNQDKFHYETTLQHVRELEGSMKVSFALQYPG 494

  Fly   266 --------------STQGPYILFGPPGTGKTTTIVEAI--LQLRLQQPQSRI--LVTAGSNSACD 312
                          |.:.|...|.|..........:||  ::.|:.:|....  ::..|.    |
Worm   495 RPVKACNWKNGTKFSIETPAGTFVPAAVDHAVQSTDAITTIECRILRPADNAVHILAVGE----D 555

  Fly   313 TIALKLCEYIESNIRLQEHFAQQKLPEPDHQLIRVYSRSIYEKGFASVPSL-------------- 363
            .:.:|..:..:.::     .|...:...|..|.|       .||.|:..:|
Worm   556 AVLIKQTKEADGHL-----LAATPVVPVDTVLDR-------NKGLATFAALNGGPIIASNGLNYP 608

  Fly   364 ----LLKNSNCSKSIYDHIKASRIVKYGIIVATLCTVARLVTDTLGRYNFFTHIFIDEAGASTEP 424
                ..:|..||......|:|...:|.|.:
Worm   609 HKEFRYQNFVCSAQQSTFIQACCDLKLGAL----------------------------------- 638

  Fly   425 EALIGIMGIKQTADCHVILSGDHKQLGAVIKSNRAASLGLSRSLMERLLQSDCYKSDENGN---- 485
             :|.|..|..:|                  |:..|.::..|...::|::.|    ::.||.
Worm   639 -SLDGAFGTGKT------------------KAVAATAIEFSNQNIQRVIIS----ANNNGAVKAI 680

  Fly   486 YDRNRQMRLCRNYRSHPQIVRLFNELYYNGELKAQAPAMDVNL--AANWSVLTNPQFPIIFQATH 548
            :|..|.:.    .|...::||                ||...|  .|...|||...|||:::
Worm   681 HDAIRSLA----PRGRVKVVR----------------AMSARLRDEAKPEVLTEDDFPILWR--- 722

  Fly   549 GVTNREQNSTSSYNNLEAEVICWYVKRLINDRVVGQEDVGIVAP--YTAQGKLVTKLLQSKGYPN 611
                              ||....|:.:....|.|.....|.|.  ..|.|.|.:.:|.::
Worm   723 ------------------EVFTEVVQSVNRPNVRGTHPAIIDAARHLNAHGLLPSPMLNNE---- 765

  Fly   612 VEVGSVETYQG--------------REKTIII---ASLVKSFTNMGFMCNPRRVN-VLLSRAKAL 658
            :.|.....|:.              .|..|||   ||:..:..::||......:. |:|..|..:
Worm   766 IRVRCKAPYKTEPPAHTIWTALMKIHETAIIIGTTASIHTALNDIGFASKANEIGLVMLDEASQI 830

  Fly   659 -LILVGNPVTLRHHSDFKFVI 678
             :|.:|...|  |....|||:
Worm   831 PMIKIGGLAT--HFPKAKFVL 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6967	NP_611185.3	AAA_11	251..456	CDD:289831	34/256 (13%)
		AAA_19	256..323	CDD:289986	13/88 (15%)
		UvrD_C_2	464..665	CDD:304668	46/227 (20%)
C41D11.6	NP_491376.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156478
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740