DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6967 and C44H9.4

DIOPT Version :9

Sequence 1:	NP_611185.3	Gene:	CG6967 / 36922	FlyBaseID:	FBgn0034187	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_506213.2	Gene:	C44H9.4 / 179760	WormBaseID:	WBGene00008099	Length:	1099	Species:	Caenorhabditis elegans

Alignment Length:	759	Identity:	177/759 - (23%)
Similarity:	295/759 - (38%)	Gaps:	218/759 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 SVDKVSSTTVHVRFSRKHKAVLSGQRFYAIIRSRRLTIRYMY-----RALNLLQESPLVRRYLFP 202
            |:|..|......|::...|..::||.     .|.:.:|..:.     ::|.:....|.....|..
Worm   413 SIDNPSKQPTEGRWNPNQKIEINGQG-----ESLKTSIETVVLGNNRKSLEITATIPKNNNKLLN 472

  Fly   203 FPSWLTQLVDNSQI----KVCCDGHLPNWMQGRPQEPAT-----PTSL---SLLNST-------- 247
            |.:. |.:|..||.    ::.|:     ::|  ...|::     .|:|   |.:|||
Worm   473 FQTG-TWIVSQSQFLETPRLDCE-----FLQ--KMSPSSNGRRIVTALYGGSPINSTGNINWNKQ 529

  Fly   248 --------IYSNAEQLEAVQRIVAGPSTQGPYILFGPP-GTGKTTTIVEAILQLRLQQPQS---- 299
                    |..|..|.:.|..|::|.    |.||...| |.||:.|||.|.::|:.:..:|
Worm   530 FEFPSKIPIGLNQYQNQYVSMILSGV----PLILGNSPFGCGKSMTIVTAAVELQKKYMRSESFN 590

  Fly   300 --RILVTAGSNSACDTI--ALKL--CEYI-------ESN---------------IRLQEHFAQ-- 334
              ::|||..:|:..:.|  ||||  |::|       |||               |.:::.|.:
Worm   591 KQQLLVTQSNNAGVNLIEFALKLHKCDHIRFLRYVSESNWNSLPDSSKTELDMPILMEDEFFEWA 655

  Fly   335 -----QKLPEPDHQLIRVYSRSIYE--------KGF-----ASVPSLLLKNSNCSKSIYDHIKAS 381
                 ||  |....|.|...::|.|        ||.     ..:...:|||....|.....:|.:
Worm   656 TNTEIQK--ENGENLTREMKKAIVEQSTQKYHCKGILVGEAKRIYENILKNQREHKPSQAILKEA 718

  Fly   382 RIVKYG--IIVATLCTVARLVTDTLGRYNFFTHIFIDEAGASTE----------PEALIGIMG-I 433
            ....|.  |||:|..::..|:.:.:.|  ..::|..|||....|          |.|..|::| |
Worm   719 FFALYAPDIIVSTADSIHNLLENNVLR--DVSNIQFDEASQVPEHTLISLLHKFPNASFGLVGDI 781

  Fly   434 KQ-TADCHVILSGDHKQLGAVIKSNRAASLG--LSRSLMERLLQSDCYKSDENGNYDRNRQMRLC 495
            .| .|.|...|.|..|..|          :|  ::|:..:::.....              :||.
Worm   782 NQLPAYCDDDLQGLLKDYG----------IGKTMARASRDKMFPQSI--------------LRLV 822

  Fly   496 RNYRSHPQIVRLFNELYYNGEL--KAQAPAMDVNLAANWSVLTNPQFPIIFQATHGVTNREQN-- 556
              ||.||...::.::|:|||:|  ..:....|..:.....:..|..|||:      |.|.|::
Worm   823 --YRCHPTTTKILSDLFYNGQLISGVEKNQRDEFMRMRPDIWPNSSFPIL------VLNHEKDGY 879

  Fly   557 --STSSYNNLEAEVICWYVKRLINDRVVG----QEDVGIVAPYTAQGKLVTKLLQSKGYPNVEVG 615
              .||..||.|.:.:...|. |:..:|.|    :.|:||::.|.||..|:...|:.   .:|:.|
Worm   880 RMGTSVANNSEKDQVVRIVS-LLTKKVKGYGLSESDIGIISFYKAQTSLLADALKK---TDVKCG 940

  Fly   616 SVETYQGREKTIIIASLVKSFTNMGFMCNPRRVNVLLSRAKALLILVGNPVTLRHHSDFKFV--- 677
            :::.:||.|:.::|........:: ||....||||.:|||:...|::||...|:....:..:
Worm   941 TIDAFQGTEREVMIVCCTNKNPSL-FMQEGTRVNVAMSRARQATIIIGNIAKLKKAKHWDTIAQS 1004

  Fly   678 --INECK-----------------------KHGTYLLKKRDSGQRPHI----LIKADESNEESSS 713
              ||:|.                       |....:.|.::.|:  ||    .:|..|..|:||.
Worm  1005 AQINKCSMEVSTFGGSEQKQPQMVQIKCTAKKSNKIQKNQNEGK--HISISQTVKTKEDTEQSSK 1067

  Fly   714 EPEDEDDKLIPSYARMQQHTDAAIHKIKAHPTNENDQLANSFKI 757
                      |...|.:::.    :.|..:.||.....|.|..|
Worm  1068 ----------PQQRRRRRNR----NNIGQNSTNGRKNSATSSTI 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6967	NP_611185.3	AAA_11	251..456	CDD:289831	72/271 (27%)
		AAA_19	256..323	CDD:289986	27/84 (32%)
		UvrD_C_2	464..665	CDD:304668	54/210 (26%)
C44H9.4	NP_506213.2	AAA_11	539..786	CDD:289831	66/254 (26%)
C44H9.4	NP_506213.2	UvrD_C_2	823..988	CDD:304668	50/175 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820