DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6967 and Mov10

DIOPT Version :9

Sequence 1:	NP_611185.3	Gene:	CG6967 / 36922	FlyBaseID:	FBgn0034187	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001156912.1	Gene:	Mov10 / 17454	MGIID:	97054	Length:	1077	Species:	Mus musculus

Alignment Length:	780	Identity:	243/780 - (31%)
Similarity:	363/780 - (46%)	Gaps:	144/780 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YYPPSNEMIEANTNQDLSANNSVFGDFMKTKRLEFYNVCSVMQTLLTIDDLS---NMELYAQLIQ 67
            ||||   ::.......|....|:|     |...|...:.:.::|.|...:..   .:.|:.:.:|
Mouse   368 YYPP---ILLRQLLPTLLQGPSIF-----TAPKEVAEIKAQLETTLKSRNYEVKLRLLLHLEELQ 424

  Fly    68 SDVPVQRVSKLTYKITFKSTPVNAEDFVAPNLDQVVLVPKASLLASPLPKQLVLALLPHPHEDLE 132
            .:..::.....:..:|:.....|      |.|..:.:...|....|.|....:.|||   ..:.:
Mouse   425 MEHDIRHYDLDSVPMTWDPVDQN------PRLLTLEVPGVAESRPSVLRGDHLFALL---SSETQ 480

  Fly   133 PGDPM----LRHVASVDKVS---STTVHVRFSRKHKAVLSGQRFYAIIRSRRLTIRYMYRALNLL 190
            ..||:    ..|...:|:|.   ||::..||       :.|..|.......|..:|..:|||.|.
Mouse   481 QDDPVTYKGFVHKVELDRVKLSFSTSLLSRF-------VDGLTFKVNFTFNRQPLRVQHRALELT 538

  Fly   191 QE---SPLVRRYLFPFPSWLTQLVDNSQIKVCCDGHLPNWMQGRPQEPATPTSLSLLNSTIYSNA 252
            ..   .|:    |||..|....|:. |.:|                       ..|.:.::.||.
Mouse   539 GRWVLWPM----LFPVASRGVSLLP-SDVK-----------------------FKLYDRSLESNP 575

  Fly   253 EQLEAVQRIVAGPSTQGPYILFGPPGTGKTTTIVEAILQLRLQQPQSRILVTAGSNSACDTIALK 317
            |||:|::.||.|.:...|||:|||||||||.|:||||.|:....|::.||..|.|||..|.
Mouse   576 EQLQAMKHIVRGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADL---- 636

  Fly   318 LCEYIESNIRLQEHFAQQKLPEPDHQLIRVYSRSIYEKGFASVPSLLLK--NSNCSKSIYDHIKA 380
            ||:      ||:.|     ||...::|: ..||.|     ..||..:..  |.:..|..|.:...
Mouse   637 LCQ------RLRVH-----LPSSIYRLL-APSRDI-----RMVPEDIKTCCNWDAKKGEYVYPAK 684

  Fly   381 SRIVKYGIIVATLCTVARLVTDTLGRYNFFTHIFIDEAGASTEPEALI---GIMGIKQTAD--CH 440
            ..:.:|.:::.||.|.:|||:... ..:.||||||||||...|||:|:   |:|.:|:|.:  ..
Mouse   685 KHLQQYRVLITTLITASRLVSAQF-PIDHFTHIFIDEAGHCMEPESLVAIAGLMDVKETGNPGGQ 748

  Fly   441 VILSGDHKQLGAVIKSNRAASLGLSRSLMERLL-QSDCYKSDENGNYDRNRQMRLCRNYRSHPQI 504
            ::|:||.:|||.|::|..|...||..||:|||| .:..||...|| ||.....:|.|||||||.|
Mouse   749 LVLAGDPRQLGPVLRSPLALKHGLGYSLLERLLAYNSLYKKGPNG-YDPQFITKLLRNYRSHPTI 812

  Fly   505 VRLFNELYYNGELKAQAPAMDVNLAANWSVLTNPQFPIIFQATHGVTNREQNSTSSYNNLEAEVI 569
            :.:.|:|||:|||:|.|..:|......|..|....|||||....|...||.||.|.:|..||..:
Mouse   813 LDIPNQLYYDGELQACADVVDRERFCRWEGLPQQGFPIIFHGVMGKDEREGNSPSFFNPEEAATV 877

  Fly   570 CWYVKRLI------NDRVVGQEDVGIVAPYTAQGK----LVTKL-LQSKGYPNV---EVGSVETY 620
            ..|:|:|:      ....:...:||:::||..|.:    .:||| .:.:|..::   :|||||.:
Mouse   878 TSYLKQLLAPSSKKGKARLSPRNVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEF 942

  Fly   621 QGREKTIIIASLVKSFT---------NMGFMCNPRRVNVLLSRAKALLILVGNPVTLRHHSDFKF 676
            ||:|:::|:.|.|:|..         |:||:.||:|.||.::|||||||:||||:.|.|..|:|.
Mouse   943 QGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKT 1007

  Fly   677 VINECKKHGTYL----------------------LKKRDSGQRPHILIKADESNEES---SSEPE 716
            .:..||::|.|.                      |....||.|.|..:..:...|..   ..|||
Mouse  1008 FLEFCKENGGYTGCPFPAKLDLQQGQDLLQGLSKLSPSTSGPRRHQNLPQEREGEGGLPLQVEPE 1072

Fly 717 716
Mouse 1073 1072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6967	NP_611185.3	AAA_11	251..456	CDD:289831	82/211 (39%)
		AAA_19	256..323	CDD:289986	32/66 (48%)
		UvrD_C_2	464..665	CDD:304668	89/224 (40%)
Mov10	NP_001156912.1	AAA_11	574..765	CDD:289831	82/212 (39%)
		P-loop_NTPase	574..>761	CDD:304359	81/208 (39%)
		AAA_12	772..996	CDD:289832	89/224 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4684
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9180
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.760