DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6967 and zgrf1

DIOPT Version :9

Sequence 1:	NP_611185.3	Gene:	CG6967 / 36922	FlyBaseID:	FBgn0034187	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_031758647.1	Gene:	zgrf1 / 100327248	XenbaseID:	XB-GENE-6461443	Length:	1948	Species:	Xenopus tropicalis

Alignment Length:	806	Identity:	180/806 - (22%)
Similarity:	311/806 - (38%)	Gaps:	197/806 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 VFGD------FMKTKRLEFYNVCSVMQTLLTIDDLSNMELYAQLI--QSDVPVQRVSKLTYKITF 84
            |.||      |:::.::..|....:|...::.....:...:.::|  .||...:..:||..|:..
Frog  1250 VMGDMKSVASFVRSHKVALYEESHLMVRKVSGFQNKSFGKFKKIINANSDFAGESKTKLYLKLNR 1314

  Fly    85 KSTPVNAEDFVAPNLDQVVLVPKASLLASPLPKQLVLALLPHPHEDLEPGDPMLRHVASVDKVSS 149
            |      |:..|.:.|.:.:|.| ::...|:...:..::...|..:.|.....|:..:..:..|:
Frog  1315 K------ENSSAYSKDDLWVVSK-TIDFEPVDTFVAFSVFFGPSANNEIEIQPLKGYSPSNWPSN 1372

  Fly   150 TTVHVRFSRKHKAVLSGQRFYAIIRSRRLTIRYMYRALNLLQES------PLVRRYL-------- 200
            |.||        |||      ....|..||      :|..:||.      |::...|
Frog  1373 TLVH--------AVL------VCNASTELT------SLRNIQEHLNPSTLPIMPHLLKMQSEQEG 1417

  Fly   201 --------FPFPSWLTQLVDNSQIKVCCDGHLPNWMQGRPQEPATPTSLSLLNSTIYSNAEQLEA 257
                    |..||...::....::..|      :::..:.||......|         |.:|..|
Frog  1418 ESKTNTGKFKPPSLTAKIPQRCELPSC------SFILAKSQEMIEQFRL---------NEDQATA 1467

  Fly   258 VQRIVAGPST-QGPYILFGPP--------GTGKT---TTIVEAILQL--------RLQQPQSRIL 302
            :.:|....:| .|.|....||        |.||:   :.:|..::||        ..:....:||
Frog  1468 LMQIAQMMTTAAGSYKAVAPPITVIHGVFGAGKSYLLSVVVLFLVQLFERGNPAEGYEASPWKIL 1532

  Fly   303 VTAGSNSACDTIALKLCEYIESNIRLQEHFAQ-------QKLPEPDHQLIRVYSRSIY---EKGF 357
            :::.:|.|.|.:.|.|         |...|:|       :|:.:|      :...|::   |...
Frog  1533 ISSSTNVAVDRVLLGL---------LDLGFSQFVRVGSIRKIAKP------ILPFSLHAGSENEN 1582

  Fly   358 ASVPSLL---------LKNSNCSKSIYDHIKASRIVKYGIIVATLCTVARLVTDTLGRYNF---- 409
            ..:..||         ::.:...|||..|       |.|...|.|..| |:|..|.....|
Frog  1583 EQIKELLALLKDDLTPVEKAYVRKSIEQH-------KLGTNKALLGQV-RVVGATCAACPFACMS 1639

  Fly   410 ---FTHIFIDEAGASTEPEALIGIMGIKQTADCH-VILSGDHKQLGAVIK-SNRAASLGLSRSLM 469
               |..:.:||....|||.:::.:...:    |. :||.||.|||...|: |..|...||.::|.
Frog  1640 NLKFPVVVLDECSQMTEPASMLPVARFQ----CEKLILVGDPKQLSPTIQGSEPAHEKGLEQTLF 1700

  Fly   470 ERLLQSDCYKSDENGNYDRNRQMRLCRNYRSHPQIVRLFNELYYNGELKAQAPAMDVNLAANWSV 534
            .||    |...        ::.:.|...||.||.|..:.|||:|:..|.......|.....:|
Frog  1701 SRL----CLMG--------HKAIILRTQYRCHPAICSIANELFYDSHLINGVSEEDRKPLLDW-- 1751

  Fly   535 LTNPQFP-IIFQATHGVTNREQNSTSSYNNLEAEVICWYVKRLINDRVVGQEDVGIVAPYTAQGK 598
                 .| :.|...:| |.:.:.:.|.||..||......::.||...:.|.. :|::..|.:|..
Frog  1752 -----LPTLCFYNVNG-TEQVEGNNSFYNMEEANFTVKLIQSLIASGIEGSM-IGVITLYKSQMY 1809

  Fly   599 LVTKLLQSKGYPN------VEVGSVETYQGREKTIIIASLVKSFTNMGFMCNPRRVNVLLSRAKA 657
            .:..||.|..:.:      |:|.:|:.:||.||.|||.|.|:: ..:||:.:.:|:||.|:|.|.
Frog  1810 KIFSLLASSAHCDSTDIKAVQVSTVDAFQGAEKEIIILSCVRT-RQVGFIDSEKRMNVGLTRGKR 1873

  Fly   658 LLILVGNPVTLRHHSDFKFVINECKKHGTYLLKKRDSGQRPHILIKADESNEESSSEPEDEDDKL 722
            .|:::.|...||.:..::.||:.|         :|......|:            |:.|::.:.:
Frog  1874 HLLIIANLACLRKNKLWEHVIHHC---------ERQKNGLKHV------------SQWEEKLNAI 1917

  Fly   723 IPSYARMQQHTDAAIHKIKAHPTNEN 748
            :..|...:...|....|.||...|.|
Frog  1918 LLRYQEKKIEEDMKKKKSKARECNVN 1943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6967	NP_611185.3	AAA_11	251..456	CDD:289831	59/252 (23%)
		AAA_19	256..323	CDD:289986	20/86 (23%)
		UvrD_C_2	464..665	CDD:304668	57/207 (28%)
zgrf1	XP_031758647.1	DUF2439	6..71	CDD:402138
		zf-GRF	1191..1234	CDD:399670
		DEAD-like_helicase_N	1460..1718	CDD:421690	69/305 (23%)
		AAA_12	1695..1880	CDD:404073	57/206 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910