DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6967 and helz

DIOPT Version :9

Sequence 1:	NP_611185.3	Gene:	CG6967 / 36922	FlyBaseID:	FBgn0034187	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	XP_031749843.1	Gene:	helz / 100145753	XenbaseID:	XB-GENE-5912847	Length:	1948	Species:	Xenopus tropicalis

Alignment Length:	811	Identity:	191/811 - (23%)
Similarity:	335/811 - (41%)	Gaps:	189/811 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LSANNSVFGDFMKTKRLEFYNVCSVMQTLLTIDDLSNMELYAQLIQSDVPVQRVSKLTYKIT--- 83
            ||| :.:|...:..|.|...|..:.:..||.|::::.   |.::.:.::.||.....::.:|
Frog   447 LSA-DQLFTQSVLDKSLTKCNYQARLHDLLYIEEIAQ---YKEVSKFNIKVQLQLVASFMLTGVS 507

  Fly    84 --------------FKSTPVNAEDFVAPNLDQVVLVPKASLLASPLPKQLVLALLPHPHEDLEPG 134
                          ||.|...:||.:|..|   |:....::...|:.|:..:.         ..|
Frog   508 GGAKYAQNGQLFGRFKLTETLSEDTLAGRL---VMTKVNAVYVLPVTKERSVQ---------SQG 560

  Fly   135 DPMLRHVASVDKVSSTTVHVRFSRK--HKAVLSGQRFYAI---IRSRRLTIRYMYRALNLLQESP 194
            .....:.|.:::.:...:.:|..:.  .:..|...|...:   .:..||.:..|:.||:.::::.
Frog   561 TKEKVYEAVIEEKTKDYIFLRICKDCCDELKLKPDREMQVELQFQLNRLPLCEMHYALDRVKDNS 625

  Fly   195 LVRRYLFPFPSWLTQLVDNSQIKVCCDGHLPNWMQGRPQEPATPTSLSLLNSTIYSNAEQLEAVQ 259
            :    |||..|....:               .|...|..:       .||:..:  ||:|.||:.
Frog   626 I----LFPDLSMTPPI---------------PWSPNRQWD-------ELLDPRL--NAKQKEAIL 662

  Fly   260 RIVAGPSTQ-GPYILFGPPGTGKTTTIVEAILQLRLQQPQSRILVTAGSNSACDTIALK--LCEY 321
            .|....|.| .|.::.||.|||||.|:.:|:..: |:|.::|:|:...||||.| :.:|  |..|
Frog   663 AITTPLSVQLPPILIIGPYGTGKTFTLAQAVKHI-LKQQETRVLICTHSNSAAD-LYIKDYLHPY 725

  Fly   322 IESNIRLQEHFAQQKLPEPDHQLIRVYSRSIYEKGFASV--PSLLLKNSNCSKSIYDHIKASRIV 384
            :|:.             .|..:.:|||.|:.:.|....|  ...|:.:::   |::...:...|:
Frog   726 VETG-------------NPQARPLRVYFRNRWVKTVHPVVHQYCLISSTH---SVFQMPQKEDIL 774

  Fly   385 KYGIIVATLCTVARLVTDTLGRYNFFTHIFIDEAGASTEPEALIGI-MGIKQTADCHVILSGDHK 448
            ::.::|.||.|...|....| ...|||||.:|||..:.|.|.::.: :..|.|   .::|:|||.
Frog   775 QHRVVVVTLSTSQYLCQLDL-EPGFFTHILLDEAAQAMECETIMPLALASKST---RIVLAGDHM 835

  Fly   449 QLGAVIKSNRAASLGLSRSLMERLLQSDCYKSDENGNYDRNRQMRLCRNYRSHPQIVRLFNELYY 513
            ||...:.|..|....|..||::||.  :.|.      .|...::.||.|||||..|:...:||:|
Frog   836 QLSPFVYSEFARERNLHVSLLDRLY--ELYP------VDFPCRILLCENYRSHEAIINYTSELFY 892

  Fly   514 NGELKA--QAPAMDVNLAANWSVLTNPQFPIIFQATHGVTNREQNSTSSYNNLEAEVICWYVKRL 576
            .|:|.|  :.||            ....:|:.|....|...:|:|||:.|||.|...:...|:.|
Frog   893 EGKLMASGKQPA------------HKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEEL 945

  Fly   577 INDRVV--GQED---VGIVAPYTAQGKLVTKLLQSKGYPNVEVGSVETYQGREKTIIIASLVKS- 635
            .....|  |:.|   :|:|.||..|...:...|:.|....:.|..|...||::..::..|.|::
Frog   946 RRKWPVAWGKLDEGSIGVVTPYADQVFRIRAELRKKRLSEISVERVLNVQGKQFRVLFLSTVRTR 1010

  Fly   636 ----------------------FTNMGFMCNPRRVNVLLSRAKALLILVGNPVTL-------RHH 671
                                  ..:.||:.|.:.:|..::||::|:.:||:|:.|       :..
Frog  1011 HTCKHKQTPIKRKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFW 1075

  Fly   672 SDFKFVINECKK-HG-----------------TYLLKKRDSGQRPHILIKADESNEESSSEPEDE 718
            ..|..:.:|.|. ||                 ||:|    :...|..:.:|  ..::.|..|..:
Frog  1076 EQFISICHENKSLHGITFEQIKSQLEALELKKTYVL----NPLAPEFIPRA--LRQQHSGNPSKQ 1134

  Fly   719 DDKLIPSYARMQQHTDAAIHKIKAHPTNEND 749
            ..:..|.             |.|.| .|:||
Frog  1135 QQQQSPP-------------KCKGH-HNQND 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6967	NP_611185.3	AAA_11	251..456	CDD:289831	65/210 (31%)
		AAA_19	256..323	CDD:289986	27/69 (39%)
		UvrD_C_2	464..665	CDD:304668	61/230 (27%)
helz	XP_031749843.1	zf-CCCH	192..216	CDD:395517
		DEXXQc_HELZ	652..878	CDD:350835	77/257 (30%)
		AAA_12	851..1062	CDD:404073	61/230 (27%)
		Atrophin-1	<1154..>1471	CDD:397323
		PHA03247	<1403..1831	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D286011at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010