DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8950 and Gtf3c3

DIOPT Version :10

Sequence 1:NP_611184.1 Gene:CG8950 / 36921 FlyBaseID:FBgn0034186 Length:868 Species:Drosophila melanogaster
Sequence 2:NP_001028366.1 Gene:Gtf3c3 / 98488 MGIID:2138383 Length:882 Species:Mus musculus


Alignment Length:842 Identity:269/842 - (31%)
Similarity:425/842 - (50%) Gaps:104/842 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 EASDEDEEGNDEEPSEAAGSIEKPNT----------SAQAKTSQEQSTGSGRSGGGGFRKSQLST 134
            |..|::||..:||..|.|   |:|..          :.:.|...::..          .:|:|..
Mouse    92 ETEDDEEEEEEEEEEETA---EQPTAGDVFVLEMVLNRETKKMMKEKR----------PRSKLPR 143

  Fly   135 ALQGLMGEANLSFVYGRYETAERICMEIIRQNPLASEPFYTLAEIYENR-DEVKFLNFSTLAAHL 198
            ||:|||||||:.|..|.:|.|..:|||||||.|||.|||.|||.|||:: |..|.|.|..:||||
Mouse   144 ALRGLMGEANIRFARGEHEEAILMCMEIIRQAPLAYEPFSTLAMIYEDQGDMEKSLQFELIAAHL 208

  Fly   199 NPQDRDMWIRVSDLLVQQGNLARARLIYTKAIKMLPKVYQLRLRKAQLLQKMGETNASMFTYLKM 263
            ||.|.:.|:|::::.::|.|:.:|...||||:|..|...:....::.|.::||:...:|..|.::
Mouse   209 NPSDTEEWVRLAEMSLEQDNIKQAIFCYTKALKYEPTNVRYLWERSSLYEQMGDHKMAMDGYRRI 273

  Fly   264 LPLMPPDEWKMCLNTAKNVARYFHVLEKHSLALEAMEGAYSVCGARFTLEDINIYLELLILNKQY 328
            |.|:.|.:.:..:..|:::|:.::.....:.|:..:|.|:|......::||:||..||.|.||||
Mouse   274 LNLLSPSDGERFMQLARDMAKSYYEANDSASAINIIEEAFSKHQGLVSMEDVNIAAELYISNKQY 338

  Fly   329 AKVLRCLRERTNFELE--------NDQEESLELIYFCEIPDDYVPELRAKLCVSLIHMR----AH 381
            .|.|..:.:.:...||        :::.::.|.: .|.|||....::..||.|.|:|:.    .:
Mouse   339 DKALEVITDFSGIILEKETLEEGTSEENKAAETV-TCSIPDSVPIDITVKLMVCLVHLNILEPLN 402

  Fly   382 HLLGYLIQNVQEHITLTADRVELYMDITEALMQEHKYAEAIALMSPITDGDTVECPAFVWLRQAE 446
            .||..|::...|      |..:||:|:.||.:...:|..|:.|:|.:...:.... |.||||.||
Mouse   403 PLLTTLVEQNPE------DMGDLYLDVAEAFLDVGEYNSALPLLSALVCSERYNL-AVVWLRHAE 460

  Fly   447 CLRQLNRTNEAIQSYEKVVQLAPFCYDARFTLSALLKQQGRHEEAVQALE---------QPGEAE 502
            ||:.|.....|.:||.|||.|||...|||.:||.|.:|.||.|:|::|||         |...|.
Mouse   461 CLKALGYMERAAESYSKVVDLAPLHLDARISLSILQQQLGRPEKALEALEPMYDPDTLAQDANAA 525

  Fly   503 GQPLIARLLYERCVMLQQIGRIEEFLDVGYALLSRHSIKLYNREE--MMAAANGGSAYNSESLKT 565
            .|.|  :||..|..:|...|::..:||....:|:.......||.:  :::::..|..:    |..
Mouse   526 QQEL--KLLLHRSTLLFSQGKMYGYLDTLLTMLAMLLKVAMNRAQVCLISSSKSGERH----LYL 584

  Fly   566 IIQMRSKAVDNSAEQDLQDPAKNA-ASETSDLTVKDEFELFRELVRTAFKHGMHSAAEKICFAMV 629
            |...|.|..||:.::.....||.. |..||.|..:|.:.|..:.:.|.........||     ::
Mouse   585 IKVSRDKISDNNEQETSNYDAKAIFAVLTSVLPKEDWWNLLLKAIYTLSDLARFQEAE-----LL 644

  Fly   630 TTKRFTYY--------HHEIERIMVLTCYYNDDCAI-------AFSYLRELIAKQPSQTTLWNML 679
            ......||        ..|:|       |:....||       |:.|:|.::.:..::..|||:.
Mouse   645 VDSSLEYYSFYDDRQKRKELE-------YFGLSAAILDKNFRKAYDYIRVMVMENVNKPQLWNIF 702

  Fly   680 SLMIQKGDEVRYYRYMRRLMQRHPVDTKPMRIFQGHYHLNCASFKYALNIYMPILRENP-DPLVA 743
            :.:.....:||::|:..|||.::| |...:.:..||......|||:||..|:...|..| :||..
Mouse   703 NQVTMHSQDVRHHRFCLRLMLKNP-DNHALCVLNGHNAFVSGSFKHALGQYVQAFRAYPSEPLYN 766

  Fly   744 LCIAVAFNQLSLQKKVLRKSASVAQAVAFGQRYKELRSAGHELADCAAQQEIFYNIGRIYHQANI 808
            |||.:.|..::.||.||::.|...|..:|..||..:|      ..|   ||.|||:||..||..:
Mouse   767 LCIGLTFIHMASQKYVLKRHALTVQGFSFLNRYLSIR------GPC---QESFYNLGRGLHQLGL 822

  Fly   809 LHLAVDYYEKALAVPVHPLIAE--HESTLGLQHEVAFNLHLIYRANGNKWKARQYLMRYCVV 868
            .|||:.||:||||:|  ||:.|  ....|.|:.::|:|:.|||:::||...|::.|..|||:
Mouse   823 THLAIHYYQKALALP--PLVVEGIEVDQLDLRRDIAYNMSLIYQSSGNTAMAQKLLYTYCVI 882

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8950NP_611184.1 BepA 133..268 CDD:443813 61/135 (45%)
TPR repeat 139..164 CDD:276809 14/24 (58%)
TPR repeat 169..198 CDD:276809 16/29 (55%)
TPR repeat 203..231 CDD:276809 9/27 (33%)
TPR repeat 237..264 CDD:276809 5/26 (19%)
Spy 318..>515 CDD:443119 74/217 (34%)
TPR repeat 402..430 CDD:276809 9/27 (33%)
TPR repeat 435..467 CDD:276809 16/31 (52%)
LapB 438..702 CDD:442196 84/290 (29%)
TPR repeat 472..497 CDD:276809 14/33 (42%)
Gtf3c3NP_001028366.1 LapB <142..347 CDD:442196 81/204 (40%)
TPR repeat 148..173 CDD:276809 14/24 (58%)
TPR repeat 179..207 CDD:276809 14/27 (52%)
TPR repeat 212..242 CDD:276809 10/29 (34%)
TPR repeat 247..274 CDD:276809 5/26 (19%)
TPR repeat 282..312 CDD:276809 4/29 (14%)
Spy 404..>510 CDD:443119 45/112 (40%)
TPR repeat 418..445 CDD:276809 9/26 (35%)
TPR repeat 450..481 CDD:276809 16/31 (52%)
TPR repeat 486..510 CDD:276809 12/23 (52%)
Spy 743..>882 CDD:443119 60/149 (40%)
TPR repeat 806..836 CDD:276809 18/32 (56%)
TPR repeat 841..876 CDD:276809 11/34 (32%)

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