DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8950 and GTF3C3

DIOPT Version :9

Sequence 1:	NP_001246384.1	Gene:	CG8950 / 36921	FlyBaseID:	FBgn0034186	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_036218.1	Gene:	GTF3C3 / 9330	HGNCID:	4666	Length:	886	Species:	Homo sapiens

Alignment Length:	916	Identity:	280/916 - (30%)
Similarity:	450/916 - (49%)	Gaps:	134/916 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EEIDSNDVPENELEQFQETEPLRVVDIIDCDT-DGERRCI-----------ADDEEEGALIKRYV 64
            |..|.::||.:......:::.   .|:.:.:| ||.|:.:           .|||||
Human    46 ENPDDSEVPSSSGINSTKSQD---KDVNEGETSDGVRKSVHKVFASMLGENEDDEEE-------- 99

  Fly    65 QGVQCLEFPDFCTKLEASDEDEEGNDEEPSE-AAGSI---EKPNTSAQAKTSQEQSTGSGRSGGG 125
                           |..:|:||..:|.|.: .||.:   |........|..:|:..
Human   100 ---------------EEEEEEEEEEEETPEQPTAGDVFVLEMVLNRETKKMMKEKRP-------- 141

  Fly   126 GFRKSQLSTALQGLMGEANLSFVYGRYETAERICMEIIRQNPLASEPFYTLAEIYENR-DEVKFL 189
               :|:|..||:|||||||:.|..|..|.|..:|||||||.|||.|||.|||.|||:: |..|.|
Human   142 ---RSKLPRALRGLMGEANIRFARGEREEAILMCMEIIRQAPLAYEPFSTLAMIYEDQGDMEKSL 203

  Fly   190 NFSTLAAHLNPQDRDMWIRVSDLLVQQGNLARARLIYTKAIKMLPKVYQLRLRKAQLLQKMGETN 254
            .|..:||||||.|.:.|:|::::.::|.|:.:|...||||:|..|...:....::.|.::||:..
Human   204 QFELIAAHLNPSDTEEWVRLAEMSLEQDNIKQAIFCYTKALKYEPTNVRYLWERSSLYEQMGDHK 268

  Fly   255 ASMFTYLKMLPLMPPDEWKMCLNTAKNVARYFHVLEKHSLALEAMEGAYSVCGARFTLEDINIYL 319
            .:|..|.::|.|:.|.:.:..:..|:::|:.::.....:.|:..::.|:|......::||:||..
Human   269 MAMDGYRRILNLLSPSDGERFMQLARDMAKSYYEANDVTSAINIIDEAFSKHQGLVSMEDVNIAA 333

  Fly   320 ELLILNKQYAKVLR--------CLRERTNFELENDQEESLELIYFCEIPDDYVPELRAKLCVSLI 376
            ||.|.||||.|.|.        .|.::|:.|..:::.::.|.: .|.|||....::..||.|.|:
Human   334 ELYISNKQYDKALEIITDFSGIVLEKKTSEEGTSEENKAPENV-TCTIPDGVPIDITVKLMVCLV 397

  Fly   377 HMR----AHHLLGYLIQNVQEHITLTADRVELYMDITEALMQEHKYAEAIALMSPITDGDTVECP 437
            |:.    .:.||..|::...|      |..:||:|:.||.:...:|..|:.|:|.:...:....
Human   398 HLNILEPLNPLLTTLVEQNPE------DMGDLYLDVAEAFLDVGEYNSALPLLSALVCSERYNL- 455

  Fly   438 AFVWLRQAECLRQLNRTNEAIQSYEKVVQLAPFCYDARFTLSALLKQQGRHEEAVQALE------ 496
            |.||||.||||:.|.....|.:||.|||.|||...|||.:||.|.:|.|:.|:|::|||
Human   456 AVVWLRHAECLKALGYMERAAESYGKVVDLAPLHLDARISLSTLQQQLGQPEKALEALEPMYDPD 520

  Fly   497 ---QPGEAEGQPLIARLLYERCVMLQQIGRIEEFLDVGYALLSRHSIKLYNREE--MMAAANGGS 556
               |...|..|.|  :||..|..:|...|::..::|....:|:.......||.:  :::::..|.
Human   521 TLAQDANAAQQEL--KLLLHRSTLLFSQGKMYGYVDTLLTMLAMLLKVAMNRAQVCLISSSKSGE 583

  Fly   557 AYNSESLKTIIQMRSKAVDNSAEQDLQDPAKNA-ASETSDLTVKDEFELFRELVRTAFKHGMHSA 620
            .:    |..|...|.|..|::.::.....||.. |..||.||..|.:.|..:.:.:.........
Human   584 RH----LYLIKVSRDKISDSNDQESANCDAKAIFAVLTSVLTKDDWWNLLLKAIYSLCDLSRFQE 644

  Fly   621 AEKICFAMVTTKRFTYY--------HHEIERIMVLTCYYNDDCAI-------AFSYLRELIAKQP 670
            ||     ::......||        ..|:|       |:....||       |::|:|.::.:..
Human   645 AE-----LLVDSSLEYYSFYDDRQKRKELE-------YFGLSAAILDKNFRKAYNYIRIMVMENV 697

  Fly   671 SQTTLWNMLSLMIQKGDEVRYYRYMRRLMQRHPVDTKPMRIFQGHYHLNCASFKYALNIYMPILR 735
            ::..|||:.:.:.....:||::|:..|||.::| :...:.:..||......|||:||..|:...|
Human   698 NKPQLWNIFNQVTMHSQDVRHHRFCLRLMLKNP-ENHALCVLNGHNAFVSGSFKHALGQYVQAFR 761

  Fly   736 ENPD-PLVALCIAVAFNQLSLQKKVLRKSASVAQAVAFGQRYKELRSAGHELADCAAQQEIFYNI 799
            .:|| ||.:.||.:.|..::.||.|||:.|.:.|..:|..||..||      ..|   ||.|||:
Human   762 THPDEPLYSFCIGLTFIHMASQKYVLRRHALIVQGFSFLNRYLSLR------GPC---QESFYNL 817

  Fly   800 GRIYHQANILHLAVDYYEKALAVPVHPLIAE--HESTLGLQHEVAFNLHLIYRANGNKWKARQYL 862
            ||..||..::|||:.||:|||.:|  ||:.|  ....|.|:.::|:||.|||:::||...|:..|
Human   818 GRGLHQLGLIHLAIHYYQKALELP--PLVVEGIELDQLDLRRDIAYNLSLIYQSSGNTGMAQTLL 880

  Fly   863 MRYCVV 868
            ..||.:
Human   881 YTYCSI 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8950	NP_001246384.1	TPR repeat	139..164	CDD:276809	14/24 (58%)
		TPR repeat	169..198	CDD:276809	16/29 (55%)
		TPR repeat	203..231	CDD:276809	9/27 (33%)
		TPR	219..497	CDD:223533	92/298 (31%)
		TPR repeat	237..264	CDD:276809	5/26 (19%)
		TPR repeat	276..304	CDD:276809	4/27 (15%)
		TPR repeat	402..430	CDD:276809	9/27 (33%)
		TPR repeat	435..467	CDD:276809	16/31 (52%)
		TPR_19	448..510	CDD:291240	28/70 (40%)
		TPR repeat	472..497	CDD:276809	13/33 (39%)
		TPR_12	795..864	CDD:290160	31/70 (44%)
GTF3C3	NP_036218.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..121		22/100 (22%)
		TPR 1	149..182		20/32 (63%)
		TPR_11	152..214	CDD:290150	37/61 (61%)
		TPR repeat	152..177	CDD:276809	14/24 (58%)
		TPR 2	183..216		19/32 (59%)
		TPR repeat	183..211	CDD:276809	14/27 (52%)
		TPR_11	216..280	CDD:290150	18/63 (29%)
		TPR repeat	216..246	CDD:276809	10/29 (34%)
		TPR 3	217..250		11/32 (34%)
		TPR repeat	251..278	CDD:276809	5/26 (19%)
		TPR 4	252..284		7/31 (23%)
		TPR repeat	286..316	CDD:276809	3/29 (10%)
		TPR 5	290..323		5/32 (16%)
		TPR 6	326..361		14/34 (41%)
		TPR 7	421..454		9/32 (28%)
		TPR repeat	422..449	CDD:276809	9/26 (35%)
		TPR_16	425..489	CDD:290168	26/64 (41%)
		TPR repeat	454..485	CDD:276809	16/31 (52%)
		TPR 8	456..489		19/32 (59%)
		TPR repeat	490..514	CDD:276809	11/23 (48%)
		TPR 9	491..523		13/31 (42%)
		TPR 10	733..766		10/32 (31%)
		TPR repeat	766..806	CDD:276809	15/39 (38%)
		TPR 11	811..844		19/34 (56%)
		TPR repeat	811..839	CDD:276809	16/27 (59%)
		TPR	812..842	CDD:197478	17/31 (55%)
		TPR repeat	845..880	CDD:276809	12/34 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143506
Domainoid	1	1.000	87	1.000	Domainoid score	I8044
eggNOG	1	0.900	-	-		E1_KOG2076
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40805
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2138
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55439
OrthoDB	1	1.010	-	-		D108764at33208
OrthoFinder	1	1.000	-	-		FOG0005249
OrthoInspector	1	1.000	-	-		oto88987
orthoMCL	1	0.900	-	-		OOG6_103511
Panther	1	1.100	-	-	LDO	PTHR23082
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1326
SonicParanoid	1	1.000	-	-		X4262
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800