Protein Alignment CG8950 and TFC4

DIOPT Version :10

• Sequence 1: NP_611184.1
• Gene: CG8950 / 36921
• FlyBaseID: FBgn0034186
• Length: 868
• Species: Drosophila melanogaster
• Sequence 2: NP_011561.3
• Gene: TFC4 / 852938
• SGDID: S000003279
• Length: 1025
• Species: Saccharomyces cerevisiae
• Alignment Length: 1069
• Identity: 200/1069 - (18%)
• Similarity: 376/1069 - (35%)
• Gaps: 308/1069 - (28%)

  Fly    12 EEIDSNDVPENELEQFQETEPLRVVDIIDCDTDGERRCIADDEEEGALIKRYVQGVQCLEFPDFC 76
            ||.|..|||.:  .|..|.|                   .:.|.:.:|:         .||.|:.
Yeast    47 EEYDDEDVPHD--LQLSEDE-------------------YNSERDSSLL---------AEFSDYG 81

  Fly    77 TKLEASDEDEEGNDEEPSEAAGSIEKPNTSAQAKTSQEQSTGSGRSGGGGFRKSQLSTALQGLMG 141
               |.|::|||.......||          :..|..:::....|:|.|...::..|...:..|:.
Yeast    82 ---EISEDDEEDFMNAIREA----------SNFKVKKKKKNDKGKSYGRQRKERVLDPEVAQLLS 133

  Fly   142 EANLSFVYGRYETAERICMEIIRQNPLASEPFYTLAEIYENRDEVK-FLNFSTLAAHLNPQDRDM 205
            :||.:||....:.|||:..|:|:::......:.||.:||:.:..:. ..|...||||||..|.:.
Yeast   134 QANEAFVRNDLQVAERLFNEVIKKDARNFAAYETLGDIYQLQGRLNDCCNSWFLAAHLNASDWEF 198

  Fly   206 WIRVSDLLVQQGNLARARLIYTKAIKMLPKVYQLRLRKAQLLQKMGETNASMFTYLKMLPLMPPD 270
            |..|:.|.....::.:|...:::.|.:.|..::...|::.|.:|.|:...::..:.::....|.|
Yeast   199 WKIVAILSADLDHVRQAIYCFSRVISLNPMEWESIYRRSMLYKKTGQLARALDGFQRLYMYNPYD 263

  Fly   271 EWKMCLNTAKNVARYFHVL----------------------EKHSLALEAMEGAYSVCGARFTLE 313
                     .|:.|...:|                      |:....|.|:|.|..........|
Yeast   264 ---------ANILRELAILYVDYDRIEDSIELYMKVFNANVERREAILAALENALDSSDEESAAE 319

  Fly   314 --------------------DIN-----------------------IYLELLILNKQYAKVL-RC 334
                                |||                       ::|:|.:......|.: :|
Yeast   320 GEDADEKEPLEQDEDRQMFPDINWKKIDAKYKCIPFDWSSLNILAELFLKLAVSEVDGIKTIKKC 384

  Fly   335 LR------------------ERTNFELENDQEESL-----ELIYFCEIPDDYVPELRAKLCVSLI 376
            .|                  |..|...:|...:||     |..|  .||.|    :|.:|  .|:
Yeast   385 ARWIQRRESQTFWDHVPDDSEFDNRRFKNSTFDSLLAAEKEKSY--NIPID----IRVRL--GLL 441

  Fly   377 HMRAHHLLGYLIQNVQEHITLTADRVELYMDITEALMQEHKYAEAIALMSPI--------TDGDT 433
            .:...:|:..|......:....:|..:||.:...||.:..||.|||...:|:        ||
Yeast   442 RLNTDNLVEALNHFQCLYDETFSDVADLYFEAATALTRAEKYKEAIDFFTPLLSLEEWRTTD--- 503

  Fly   434 VECPAFVWLRQAECLRQLNRTNEAIQSYEKVVQLAPFCYDARFTLSAL----------------L 482
                  |:...|.|.:::.....|.:.||..::..|...|.|.:|:.:                :
Yeast   504 ------VFKPLARCYKEIESYETAKEFYELAIKSEPDDLDIRVSLAEVYYRLNDPETFKHMLVDV 562

  Fly   483 KQQGRH--EEAVQAL------EQPGEAEGQPLI--------------------ARLLYERCVMLQ 519
            .:..:|  :|.:..:      ....:...:||:                    .|:..||.:..:
Yeast   563 VEMRKHQVDETLHRISNEKSSNDTSDISSKPLLEDSKFRTFRKKKRTPYDAERERIERERRITAK 627

  Fly   520 QIGRIEEF----LDVGYALLSRHSIKLYNREEMMAAANG--------------GSAYNSESLKTI 566
            .:.:.|:.    |:.|.....:.||.:....|::...:.              |....::...|.
Yeast   628 VVDKYEKMKKFELNSGLNEAKQASIWINTVSELVDIFSSVKNFFMKSRSRKFVGILRRTKKFNTE 692

  Fly   567 IQMRSKAVDNSAEQD--LQDP------AKNAASETSDLTVKDEFELFRELVRTAFKHGMHSAAEK 623
            :..:.:.:...||.|  .:.|      ...:|:|...|:.:..||||.||.....|   :.:.|.
Yeast   693 LDFQIERLSKLAEGDSVFEGPLMEERVTLTSATELRGLSYEQWFELFMELSLVIAK---YQSVED 754

  Fly   624 ICFAMVTTKRFTYYHHEIERI-------MVLTCYYNDDCAIA---------FSYLREL------- 665
            ....:.|.:....:..:.||:       :.:....:|:..:|         |.:.|::
Yeast   755 GLSVVETAQEVNVFFQDPERVKMMKFVKLAIVLQMDDEEELAENLRGLLNQFQFNRKVLQVFMYS 819

  Fly   666 IAKQPSQTTLWNMLSLMIQKGDEVRYY------RYMRRLMQRHPVDTKPMRIFQGHYHLNCASFK 724
            :.:.||..   |:||..||:...:|..      ||...:..:..:..|.:      |:.|..|..
Yeast   820 LCRGPSSL---NILSSTIQQKFFLRQLKAFDSCRYNTEVNGQASITNKEV------YNPNKKSSP 875

  Fly   725 YALNIYMPILREN------------------PDPLVALCIAVAFNQLSLQKKVLRKSASVAQAVA 771
            |...||..:|..:                  .||:|.|.:.::....::|:...::...:...:.
Yeast   876 YLYYIYAVLLYSSRGFLSALQYLTRLEEDIPDDPMVNLLMGLSHIHRAMQRLTAQRHFQIFHGLR 940

  Fly   772 FGQRYKELRSAGHELADCAAQQEIFYNIGRIYHQANILHLAVDYYEKALAVPVHPLIAEHESTLG 836
            :..||.::|.:   |.....:||..||:||.:|...::.:|::||.:.|         |:.....
Yeast   941 YLYRYHKIRKS---LYTDLEKQEADYNLGRAFHLIGLVSIAIEYYNRVL---------ENYDDGK 993

  Fly   837 LQHEVAFNLHLIYRANGNKWKARQYLMRY 865
            |:...|:|..:||:.:||...|...:.:|
Yeast   994 LKKHAAYNSIIIYQQSGNVELADHLMEKY 1022

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8950	NP_611184.1	BepA	133..268	CDD:443813	32/135 (24%)
		TPR repeat	139..164	CDD:276809	9/24 (38%)
		TPR repeat	169..198	CDD:276809	8/29 (28%)
		TPR repeat	203..231	CDD:276809	4/27 (15%)
		TPR repeat	237..264	CDD:276809	4/26 (15%)
		Spy	318..>515	CDD:443119	49/272 (18%)
		TPR repeat	402..430	CDD:276809	10/35 (29%)
		TPR repeat	435..467	CDD:276809	6/31 (19%)
		LapB	438..702	CDD:442196	57/362 (16%)
		TPR repeat	472..497	CDD:276809	5/48 (10%)
TFC4	NP_011561.3	TPR	124..336	CDD:440225	44/220 (20%)
		TPR repeat	164..190	CDD:276809	7/25 (28%)
		TPR repeat	197..224	CDD:276809	4/26 (15%)
		TPR repeat	229..259	CDD:276809	4/29 (14%)
		TPR repeat	264..290	CDD:276809	3/25 (12%)
		TPR	433..>553	CDD:440225	29/134 (22%)
		TPR repeat	467..495	CDD:276809	10/27 (37%)
		TPR repeat	501..531	CDD:276809	8/38 (21%)