DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8950 and gtf3c3

DIOPT Version :10

Sequence 1:NP_611184.1 Gene:CG8950 / 36921 FlyBaseID:FBgn0034186 Length:868 Species:Drosophila melanogaster
Sequence 2:NP_001243171.1 Gene:gtf3c3 / 553318 ZFINID:ZDB-GENE-040914-80 Length:918 Species:Danio rerio


Alignment Length:890 Identity:270/890 - (30%)
Similarity:438/890 - (49%) Gaps:121/890 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 DGERRCI--ADDEEEGALIKRYVQGVQCLEFPDFCTKLEASD-EDEEGNDEEPSEAAGSIEKPNT 105
            :|...|:  .||:|:|                    |:|..| |:|:|:|::..:     :..|.
Zfish    85 EGLEECVDDDDDDEDG--------------------KMEWKDIEEEDGDDDDDDD-----DDDNN 124

  Fly   106 SAQAKTSQEQSTGSGRSGGGGF------------------RKSQLSTALQGLMGEANLSFVYGRY 152
            .|    .:|:..|:|.:.|..|                  .:|:|..||:|||||||:.:..|..
Zfish   125 DA----DEEEEDGNGITPGDVFALEMELNRENKKMMKERRHRSKLPRALRGLMGEANIRYARGDK 185

  Fly   153 ETAERICMEIIRQNPLASEPFYTLAEIYENR-DEVKFLNFSTLAAHLNPQDRDMWIRVSDLLVQQ 216
            |.|..:|||||||.|:|.|||.|:|.|||:: |..|.|.|..:||||||.|.:.|::::|:.::|
Zfish   186 EDAILMCMEIIRQAPVAYEPFSTMAMIYEDQGDMEKALQFGLIAAHLNPSDCEEWVKLADMSLEQ 250

  Fly   217 GNLARARLIYTKAIKMLPKVYQLRLRKAQLLQKMGETNASMFTYLKMLPLMPPDEWKMCLNTAKN 281
            .|:.:|.:.||||||......|....::.|.:::||...:|..|.::|.|:||.:.:..:..:::
Zfish   251 DNIKQAIICYTKAIKYDSSNVQYLWERSSLYEQVGEHKQAMDGYRRILSLLPPTDGEHFMQLSRD 315

  Fly   282 VARYFHVLEKHSLALEAMEGAYSVCGARFTLEDINIYLELLILNKQYAKVLRCL----------R 336
            :|:.::...:...|:..||.|........|.|.:|:..||.|.|.|:.|.|..|          :
Zfish   316 MAKSYYESSELPSAIGVMEEALERHPELVTHECVNMAAELFIANHQHDKALEALVKFCGIVLKRQ 380

  Fly   337 ERTNFELE-------------NDQEESLELIYFCEIPDDYVPELRAKLCVSLIHMRAHHLLGYLI 388
            |:...:||             .|.||....:....|||....::|||:.|.|||.:....|..::
Zfish   381 EKVETKLEEQTLTQDTEEDTKEDTEEEKGKVIEVVIPDAVPIDIRAKMMVCLIHQQVFKPLDPML 445

  Fly   389 QNVQEHITLTADRVELYMDITEALMQEHKYAEAIALMSPITDGDTVECPAFVWLRQAECLRQLNR 453
            .::.|.  ...:..:||:|:.||.|:|.:|..|:.|:|.:...:.... |.||||.||||:.|..
Zfish   446 TSLMEQ--SPEELGDLYLDVAEAFMEEGEYNSALPLLSALVCSERYNL-AVVWLRHAECLKALGH 507

  Fly   454 TNEAIQSYEKVVQLAPFCYDARFTLSALLKQQGRHEEAVQALE---------QPGEAEGQPLIAR 509
            ...|::||.|||::||...:||..||.|.:|.||...|::|||         |...|..|.|  :
Zfish   508 LEVAVKSYSKVVEMAPLHLEARLALSTLQQQLGRPNMALEALEPMYDAETLAQDSSAAQQEL--K 570

  Fly   510 LLYERCVMLQQIGRIEEFLDVGYALLSRHSIKLYNREEMMAAANGGSAYNSESLKTIIQMRS--- 571
            ||..|..:|...||:::::|....:||........|.::...|:..|..  :.||.|...||   
Zfish   571 LLLHRSTLLLSQGRMDDYIDTVLTMLSMFLKVAMVRAQVCVVADMSSGV--KHLKLIKVSRSALT 633

  Fly   572 KAVDNSAEQDLQDPAKNAASETSDLTVKDEFELFRELVRTAFKHGMHSAAEKICFAMVTTKRFTY 636
            :.||..|..      .:...:||.|:..|.::|....:....:....:.||.:..:  |.:.:::
Zfish   634 EIVDQEAAY------LDVTGKTSVLSKDDWWKLSLRCLSVLCEEKRFAEAELLVDS--TLEYYSF 690

  Fly   637 Y-----HHEIERIMVLTCYYNDDCAIAFSYLRELIAKQPSQTTLWNMLSLMIQKGDEVRYYRYMR 696
            |     ..|:|.:.:...:.:.:...|::|:|.::.....:..|||:.:.:.....:.|::|:..
Zfish   691 YDDRVKRKELEYLGLSAAFLDHNFRTAYNYIRLMLMDSVERPQLWNVFNQITLHSQDARHHRFCL 755

  Fly   697 RLMQRHPVDTKPMRIFQGHYHLNCASFKYALNIYMPILRENPD-PLVALCIAVAFNQLSLQKKVL 760
            |||.:|| |...:.:..||..|...:||:||..||...|..|| ||.:|.|.:.|..::.||.|:
Zfish   756 RLMLKHP-DNHALYLLNGHTSLVSGTFKHALGQYMQAFRNEPDHPLHSLAIGLTFFHMACQKFVM 819

  Fly   761 RKSASVAQAVAFGQRYKELRSAGHELADCAAQQEIFYNIGRIYHQANILHLAVDYYEKALAVPVH 825
            ::.:...|..:|..||.:||      ..|   ||..||:||..||..:.|||:.||||||.:|  
Zfish   820 KRHSLTVQGFSFLWRYVDLR------GQC---QESLYNLGRALHQLGLTHLAIHYYEKALTLP-- 873

  Fly   826 PLIAE--HESTLGLQHEVAFNLHLIYRANGNKWKARQYLMRYCVV 868
            ||..|  .:..:.|:.|:|:||.|||:::|||..||..:..||.:
Zfish   874 PLKMEGIEDDQVDLRREIAYNLSLIYQSSGNKDMARHIIYTYCTI 918

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8950NP_611184.1 BepA 133..268 CDD:443813 59/135 (44%)
TPR repeat 139..164 CDD:276809 13/24 (54%)
TPR repeat 169..198 CDD:276809 15/29 (52%)
TPR repeat 203..231 CDD:276809 9/27 (33%)
TPR repeat 237..264 CDD:276809 6/26 (23%)
Spy 318..>515 CDD:443119 73/228 (32%)
TPR repeat 402..430 CDD:276809 11/27 (41%)
TPR repeat 435..467 CDD:276809 16/31 (52%)
LapB 438..702 CDD:442196 76/280 (27%)
TPR repeat 472..497 CDD:276809 12/33 (36%)
gtf3c3NP_001243171.1 LapB <166..371 CDD:442196 77/204 (38%)
TPR repeat 172..197 CDD:276809 13/24 (54%)
TPR repeat 203..231 CDD:276809 13/27 (48%)
TPR repeat 236..266 CDD:276809 11/29 (38%)
TPR repeat 271..299 CDD:276809 6/27 (22%)
TPR repeat 310..338 CDD:276809 5/27 (19%)
Spy 450..>550 CDD:443119 40/102 (39%)
TPR repeat 458..485 CDD:276809 11/26 (42%)
TPR repeat 490..521 CDD:276809 16/31 (52%)
TPR repeat 526..550 CDD:276809 10/23 (43%)
Spy 699..>874 CDD:443119 61/186 (33%)
TPR repeat 842..872 CDD:276809 18/32 (56%)
PRK02603 <862..>908 CDD:179448 22/47 (47%)

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