DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8950 and Gtf3c3

DIOPT Version :9

Sequence 1:	NP_001246384.1	Gene:	CG8950 / 36921	FlyBaseID:	FBgn0034186	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_001101709.1	Gene:	Gtf3c3 / 316810	RGDID:	1309185	Length:	883	Species:	Rattus norvegicus

Alignment Length:	847	Identity:	270/847 - (31%)
Similarity:	426/847 - (50%)	Gaps:	102/847 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 FCTKLEASDEDEEGNDEEPSE-------AAGSI---EKPNTSAQAKTSQEQSTGSGRSGGGGFRK 129
            |.:.|..::|:||..:||..|       .||.:   |........|..:|:..           :
  Rat    86 FASMLGETEEEEEEEEEEEEEEDTPEQPTAGDVFVLEMVLNRETKKMMKEKRP-----------R 139

  Fly   130 SQLSTALQGLMGEANLSFVYGRYETAERICMEIIRQNPLASEPFYTLAEIYENR-DEVKFLNFST 193
            |:|..||:|||||||:.|..|.:|.|..:|||||||.|||.|||.|||.|||:: |..|.|.|..
  Rat   140 SKLPRALRGLMGEANIRFARGEHEEAILMCMEIIRQAPLAYEPFSTLAMIYEDQGDMEKSLQFEL 204

  Fly   194 LAAHLNPQDRDMWIRVSDLLVQQGNLARARLIYTKAIKMLPKVYQLRLRKAQLLQKMGETNASMF 258
            :||||||.|.:.|:|::::.::|.|:.:|...||||:|..|...:....::.|.::||:...:|.
  Rat   205 IAAHLNPSDTEEWVRLAEMSLEQDNIKQAIFCYTKALKYEPTNVRYLWERSSLYEQMGDHKMAMD 269

  Fly   259 TYLKMLPLMPPDEWKMCLNTAKNVARYFHVLEKHSLALEAMEGAYSVCGARFTLEDINIYLELLI 323
            .|.::|.|:.|.:.:..:..|:::|:.::.....:.|:..:|.|:|......::||:||..||.|
  Rat   270 GYRRILNLLSPSDGERFMQLARDMAKSYYEANDSTSAINIIEEAFSKHQGLVSMEDVNIAAELYI 334

  Fly   324 LNKQYAKVLRCLRERTNFELE--------NDQEESLELIYFCEIPDDYVPELRAKLCVSLIHMR- 379
            .||||.|.|..:.:.:...||        :::.::.|.: .|.|||....::..||.|.|:|:.
  Rat   335 SNKQYDKALEVITDFSGIILEKETLEEGTSEENKAAETV-TCSIPDSVPIDITVKLMVCLVHLNI 398

  Fly   380 ---AHHLLGYLIQNVQEHITLTADRVELYMDITEALMQEHKYAEAIALMSPITDGDTVECPAFVW 441
               .:.||..|::...|      |..:||:|:.||.:...:|..|:.|:|.:...:.... |.||
  Rat   399 LEPLNPLLTTLVEQNPE------DMGDLYLDVAEAFLDVGEYNSALPLLSALVCSERYNL-AVVW 456

  Fly   442 LRQAECLRQLNRTNEAIQSYEKVVQLAPFCYDARFTLSALLKQQGRHEEAVQALE---------Q 497
            ||.||||:.|.....|.:||.|||.|||...|||.:||.|.:|.||.|:|::|||         |
  Rat   457 LRHAECLKALGYMERAAESYSKVVDLAPLHLDARISLSILQQQLGRPEKALEALEPMYDPDTLAQ 521

  Fly   498 PGEAEGQPLIARLLYERCVMLQQIGRIEEFLDVGYALLSRHSIKLYNREE--MMAAANGGSAYNS 560
            ...|..|.|  :||..|..:|...|::..:||....:|:.......||.:  :::::..|..:
  Rat   522 DANAAQQEL--KLLLHRSTLLFSQGKMYGYLDTLLTMLAMLLKVAMNRAQVCLISSSKSGERH-- 582

  Fly   561 ESLKTIIQMRSKAVDNSAEQDLQDPAKNA-ASETSDLTVKDEFELFRELVRTAFKHGMHSAAEKI 624
              |..|...|.|..||:.::.....||.. |..||.|...|.:.|..:.:.|.........||
  Rat   583 --LYLIKVSRDKISDNNEQETSNYDAKAIFAVLTSVLPKDDWWNLLLKAIYTLSDLSRFQEAE-- 643

  Fly   625 CFAMVTTKRFTYY--------HHEIERIMVLTCYYNDDCAI-------AFSYLRELIAKQPSQTT 674
               ::......||        ..|:|       |:....||       |:.|:|.::.:..::..
  Rat   644 ---LLVDSSLEYYSFYDDRQKRKELE-------YFGLSAAILDKNFRKAYDYIRVMVMENVNKPQ 698

  Fly   675 LWNMLSLMIQKGDEVRYYRYMRRLMQRHPVDTKPMRIFQGHYHLNCASFKYALNIYMPILRENP- 738
            |||:.:.:.....:||::|:..|||.::| |...:.:..||......|||:||..|:...|..|
  Rat   699 LWNIFNQVTMHSQDVRHHRFCLRLMLKNP-DNHALCVLNGHNAFVSGSFKHALGQYVQAFRAYPS 762

  Fly   739 DPLVALCIAVAFNQLSLQKKVLRKSASVAQAVAFGQRYKELRSAGHELADCAAQQEIFYNIGRIY 803
            :||..|||.:.|..::.||.||::.|...|..:|..||..:|      ..|   ||.|||:||..
  Rat   763 EPLYNLCIGLTFIHMASQKYVLKRHALTVQGFSFLNRYLSIR------GPC---QESFYNLGRGL 818

  Fly   804 HQANILHLAVDYYEKALAVPVHPLIAE--HESTLGLQHEVAFNLHLIYRANGNKWKARQYLMRYC 866
            ||..:.|||:.||:||||:|  |::.|  ....|.|:.::|:|:.|||:::||...|::.|..||
  Rat   819 HQLGLTHLAIHYYQKALALP--PIVVEGIEVDQLDLRRDIAYNMSLIYQSSGNTAMAQKLLYTYC 881

  Fly   867 VV 868
            |:
  Rat   882 VI 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8950	NP_001246384.1	TPR repeat	139..164	CDD:276809	14/24 (58%)
		TPR repeat	169..198	CDD:276809	16/29 (55%)
		TPR repeat	203..231	CDD:276809	9/27 (33%)
		TPR	219..497	CDD:223533	93/298 (31%)
		TPR repeat	237..264	CDD:276809	5/26 (19%)
		TPR repeat	276..304	CDD:276809	5/27 (19%)
		TPR repeat	402..430	CDD:276809	9/27 (33%)
		TPR repeat	435..467	CDD:276809	16/31 (52%)
		TPR_19	448..510	CDD:291240	29/70 (41%)
		TPR repeat	472..497	CDD:276809	14/33 (42%)
		TPR_12	795..864	CDD:290160	30/70 (43%)
Gtf3c3	NP_001101709.1	TPR_11	149..211	CDD:290150	37/61 (61%)
		TPR repeat	149..174	CDD:276809	14/24 (58%)
		TPR repeat	180..208	CDD:276809	14/27 (52%)
		TPR_11	213..277	CDD:290150	18/63 (29%)
		TPR repeat	213..243	CDD:276809	10/29 (34%)
		TPR repeat	248..275	CDD:276809	5/26 (19%)
		TPR repeat	283..313	CDD:276809	4/29 (14%)
		TPR repeat	419..446	CDD:276809	9/26 (35%)
		TPR_16	422..486	CDD:290168	26/64 (41%)
		TPR repeat	451..482	CDD:276809	16/31 (52%)
		TPR repeat	487..511	CDD:276809	12/23 (52%)
		TPR repeat	763..803	CDD:276809	15/39 (38%)
		TPR repeat	808..836	CDD:276809	16/27 (59%)
		TPR repeat	842..877	CDD:276809	11/34 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337249
Domainoid	1	1.000	86	1.000	Domainoid score	I7931
eggNOG	1	0.900	-	-		E1_KOG2076
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40805
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2024
OMA	1	1.010	-	-		QHG55439
OrthoDB	1	1.010	-	-		D108764at33208
OrthoFinder	1	1.000	-	-		FOG0005249
OrthoInspector	1	1.000	-	-		oto96119
orthoMCL	1	0.900	-	-		OOG6_103511
Panther	1	1.100	-	-	LDO	PTHR23082
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4262
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770