Protein Alignment CG8950 and sfc4

DIOPT Version :10

• Sequence 1: NP_611184.1
• Gene: CG8950 / 36921
• FlyBaseID: FBgn0034186
• Length: 868
• Species: Drosophila melanogaster
• Sequence 2: NP_587924.1
• Gene: sfc4 / 2539187
• PomBaseID: SPCC16C4.14C
• Length: 1006
• Species: Schizosaccharomyces pombe
• Alignment Length: 1063
• Identity: 219/1063 - (20%)
• Similarity: 393/1063 - (36%)
• Gaps: 266/1063 - (25%)

  Fly     3 DSDSNEVLIEEIDSNDVPENELEQFQETEPLRVVDIIDCDTDGERRCIADDEEEGALIKRYVQGV 67
            ||:.||...:..|:.|....:|..:       :.:|:|     |.|.:::.:
pombe    11 DSNMNETQNDTTDNFDAEMQDLNGY-------ISEIVD-----EARNVSEVD------------- 50

  Fly    68 QCLEFPDFCTKLEA----SDE--DEEGNDEEP--SEAAGSIEKPNTSAQAKTSQEQSTG-----S 119
              .:|....:.|:|    |||  |.||:|:|.  |:.|...|....:.:.:.:.:...|     .
pombe    51 --AKFLGDTSALQAEGLWSDEESDYEGSDDESNFSKTASRTEDDIANEEWEENLKAVAGFRKVRK 113

  Fly   120 GRSGGGGFRKSQL--STALQGLMGEANLSFVY-GRYETAERICMEIIR--QNPLASEPFYTLAEI 179
            |..|.|...::.:  |..:|.::..||..|.. |.::.|:::..||:|  .|.:|:  :..|.|.
pombe   114 GHKGRGRVSRADMLPSVEVQQMLSLANHLFAQEGNFDEAQKLAEEIVRIDNNVIAA--WKMLGEC 176

  Fly   180 YENRDE-----VKFLNFSTLAAHLNPQDRDMWIRVSDLLVQQGNLARARLIYTKAIKMLP----- 234
            :..|..     .|.|.....||||.|:|.::|...:.|........:|...|.:|:...|
pombe   177 HRQRGNGRVNIEKCLIAWMAAAHLKPKDHELWFTCAKLSESLEFWDQADYCYNRAVSAKPPNKSE 241

  Fly   235 -KVY----------QLRLRKA----QLLQKMGETNASMFTYLKMLPLMPPDEWKMCLNTAKNVAR 284
             |.|          ...|:||    :.|.:....|||:   ||.|.     |..:.::..:.:.:
pombe   242 LKKYIWNRSVLNKEHGSLKKAAEGFKFLLQSSPYNASI---LKNLA-----EIYIKIHAPREILK 298

  Fly   285 YFHVLEKHSLALEAMEGAYSVCGARFTLEDINIYLELLILNKQYAKVLRCL---------RERTN 340
            .|.:..|:.....|......:    |.|..:|:|.|||:|:.|::.::|.:         |:..:
pombe   299 QFEIAWKYFYQYPAPPIGNDI----FDLPTLNLYAELLLLDHQWSNLIRLINRGVRWFRGRKSES 359

  Fly   341 F--ELENDQEESLE--LIYFCEIPDDY-------VPEL-RAKLCVSLI---HMRAHHLLGYLIQN 390
            |  |.::|:|..::  ...|....:::       :|.| |.||.::.:   .:....|...:|:|
pombe   360 FWDEFDDDREWDVDERRREFPNASEEHTNKEAYLLPHLFRTKLGIARLKTGELPEAELHFSVIKN 424

  Fly   391 VQEHIT--LTADRVELYMDITE--------ALMQEHKYAEAIALMSPITDGDTVECPAFVWLRQA 445
            :.....  :..|..:.||||..        .|:..|:.|:.|.|                |....
pombe   425 LPPDYAWGMLYDIAKAYMDIERLDLALEYFVLICNHEPAQNIGL----------------WYNMG 473

  Fly   446 ECLRQLNRTNEAIQSYEKV-----------VQLAPF----------------CYDARFTLSALLK 483
            .|..:|.....|.|..|.:           ::||..                .::.|..::.|.:
pombe   474 VCYLELKEYEHAQQCMEAILIVDNSNTNALIKLAEINELQDNRDAALEIVTNIFEQRRNINELER 538

  Fly   484 QQGR---HEEAVQA-------------------LEQPGEAEGQPLI------ARLLYERCVMLQQ 520
            :|.:   ||:.|.:                   :.:..|...|..|      .|..::..::.|.
pombe   539 EQSQNEDHEKNVGSQLFVGNQKVPQDKWEKRARISRSKEEARQFTIWKTEETQRRFHKLDILRQS 603

  Fly   521 IGR-------IEEFLDVGYALLSRH-SIKLYNREEMMAAANGG-----SAYNS--ESLKTIIQMR 570
            :.:       :.|:|.:...|:... |||.:...|..|.|..|     :.|.|  :.|.::|...
pombe   604 LKKEENVSESLNEWLAIASELIDEFVSIKAFFPSEKKARARAGLLTRRTRYASLNDQLTSMINRL 668

  Fly   571 SKAVDNSAEQDLQDPAKNAASETSDLTVKDEFELFRELVRTAFKHG--------MHSAAEKICFA 627
            :.::..:...||............::::...::||.|......|.|        :.:|...|.|.
pombe   669 NDSLTRTKYGDLDLDTILRTGYFRNVSIDAWYQLFVEFSLRLTKVGSVQQAYDVLTTAMGAILFD 733

  Fly   628 MVTTKRFTYYHHEIERIMVLTCYYNDDCAIAFSYLRELIAKQPSQTTLWNMLSLMIQKGDE---- 688
            ..|.||     ..:...|:....|..|...|.:.||.:......:...:.:.|.::.:|.|
pombe   734 QDTIKR-----QNLRWCMLACSMYARDPQGALTPLRWVFTTFQFRQDTYRLFSAVLSQGYECSRA 793

  Fly   689 ----------VRYYRYMRRLMQRH------------------PVDTKPMRI-FQGHYHLNCASFK 724
                      :|..:.|.:||...                  |....|:.: ..||......|:.
pombe   794 FVDSANQKFLLRLIKLMDQLMSNSLVSGAATLVKNDDGLATVPTSYDPVLVLLYGHIMARNRSWI 858

  Fly   725 YALNIYMPILRENPD-PLVALCIAVAFNQLSLQKKVLRKSASVAQAVAFGQRYKELRSAGHELAD 788
            .|:|.|......||| |:..|.:.:|:...::|:....:...:.|...|..||.:|| ....|.:
pombe   859 PAINYYSRAFAINPDCPITNLSLGLAYLHRAMQRLSDNRHYQILQGFTFLYRYYDLR-VNEGLGE 922

  Fly   789 CAAQQEIFYNIGRIYHQANILHLAVDYYEKALAVPVHPL-----IAEHESTLGLQH----EVAFN 844
               :||..||:|:.||...:.|.||.|||..|.  :.|:     :...|||:...:    |.|:|
pombe   923 ---KQEALYNLGKAYHFIGLEHYAVKYYEAVLG--LSPMSQGDKMTSSESTVSTTYDFGFEAAYN 982

  Fly   845 LHLIYRANGNKWKARQYLMRYCV 867
            |.|||..:||...|.|...:|.:
pombe   983 LRLIYICSGNIKLAFQISSKYLI 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8950	NP_611184.1	BepA	133..268	CDD:443813	41/162 (25%)
		TPR repeat	139..164	CDD:276809	7/25 (28%)
		TPR repeat	169..198	CDD:276809	8/33 (24%)
		TPR repeat	203..231	CDD:276809	5/27 (19%)
		TPR repeat	237..264	CDD:276809	10/40 (25%)
		Spy	318..>515	CDD:443119	49/285 (17%)
		TPR repeat	402..430	CDD:276809	9/35 (26%)
		TPR repeat	435..467	CDD:276809	6/42 (14%)
		LapB	438..702	CDD:442196	59/355 (17%)
		TPR repeat	472..497	CDD:276809	6/46 (13%)
sfc4	NP_587924.1	TPR repeat	132..161	CDD:276809	8/28 (29%)
		TPR	142..>306	CDD:440225	39/173 (23%)
		TPR repeat	166..200	CDD:276809	8/35 (23%)
		TPR repeat	205..233	CDD:276809	5/27 (19%)
		TPR repeat	243..271	CDD:276809	6/27 (22%)
		TPR	402..600	CDD:440225	32/213 (15%)
		TPR repeat	434..459	CDD:276809	6/24 (25%)
		TPR repeat	465..495	CDD:276809	8/45 (18%)