Protein Alignment CG8950 and tftc-3

DIOPT Version :10

• Sequence 1: NP_611184.1
• Gene: CG8950 / 36921
• FlyBaseID: FBgn0034186
• Length: 868
• Species: Drosophila melanogaster
• Sequence 2: NP_505626.1
• Gene: tftc-3 / 179419
• WormBaseID: WBGene00014114
• Length: 1037
• Species: Caenorhabditis elegans
• Alignment Length: 1089
• Identity: 239/1089 - (21%)
• Similarity: 414/1089 - (38%)
• Gaps: 285/1089 - (26%)

  Fly     6 SNEVLIEEID--------SNDVPENELEQFQETEPLRVVDIIDCDT----------DGERRCI-- 50
            :::.||||.:        .:||||.|...|.:.:....: |...||          .|.|:.:
 Worm     8 TSDFLIEEEEEYGNILEQGSDVPEVEEYDFDDDDDTNGI-IAGIDTKPHLTGLHNGSGNRKRVEE 71

  Fly    51 ----ADDEEEGALIKRY------------VQGVQCLE--------------FPDFCTKLEASDED 85
                .||||....|.|:            |.|.|.|:              ..|...:::.:|:|
 Worm    72 PAEAIDDEELVNAINRFMRNEYDYDQFMRVTGGQTLKEELGAKQKRSARNNVVDEVEEIDTADDD 136

  Fly    86 EEGNDEEPSEAAGSIEKPNTSAQAKTSQE-QSTG--------------------SGRSGG----- 124
            || .|:|..|....:|:.:||..|.:|.. ||.|                    ||:..|
 Worm   137 EE-EDDEDVELMEDVEEVSTSQHAGSSYSFQSAGPSDRYDALPEEARYIMTQMMSGKDEGQVNHS 200

  Fly   125 ------------------------GGFRKSQLST----------------ALQGLMGEANLSFVY 149
                                    .|.:....||                .|..::|:||:....
 Worm   201 DEMEVEYEVETEEREPPPLKQVKIEGQKADSTSTETPATNAEPRDRGKLKRLDAMLGQANVLAAR 265

  Fly   150 GRYETAERICMEIIRQNPLASEPFYTLAEIYEN-RDEVKFLNFSTLAAHLNPQ-DRDMWIRVSDL 212
            |....|..|..|:|:|:...:..:..:|.:||. .|..|.|.|..||:||:|: ..|.|:...|.
 Worm   266 GNITDAMEILREVIKQDHKHAIAYQQIATVYEQLGDHQKALQFGLLASHLDPKTPPDDWVHWGDE 330

  Fly   213 LVQQGNLARARLIYTKAIKMLPKVYQLRLRKAQLLQKMGETNASMFTYLKMLPLMPPD------E 271
            ..:.|.:..|.:.|.:||.:..:.::...::.::|.::.....:|.|.|:...|:..:      |
 Worm   331 AEKFGMIEEAAVCYDRAIHLNNENWKFYEKRIEMLDRLNLRPLAMRTRLQAAQLINNEILQVDFE 395

  Fly   272 WKMCLNTAKNVARYFHVLEKHSLALEAMEGAYSVCGARF---------TLEDINIYLE------- 320
            |...|  .:.||:|:..:.....|::::| |:.:....|         ||  |.:||.
 Worm   396 WFHDL--IRKVAQYYITMNDEEKAIQSLE-AFVLRSKEFERDAEPQHETL--IGMYLAKSKFRQA 455

  Fly   321 ----LLILNKQYAKVLR-------CLRERTNFELENDQEESLELIYFCEIPDDYVPELRAKLCVS 374
                |.:.|.  .|.:|       ||...||        .:.|.:.|..:..|    :...:.|:
 Worm   456 GMSILAMCNG--VKAIRSTTKDPACLITYTN--------GTYECLPFPPVGSD----IDYDIDVN 506

  Fly   375 LIHMRAH-HLLGYLI-------QNVQEHITLTAD-RVE----LYMDITEALMQEHKYAEAIALMS 426
            |..:..| ||:..|.       .:|.||..|..: .||    ..:|:............|:..:.
 Worm   507 LFPVSMHCHLVICLFSLDEVEQSSVLEHKLLKRNFNVEEDEGFILDVPRLYKNRGHPKLAMNFLD 571

  Fly   427 PITDGDTV--ECPAFVWLRQAECLRQLNRTNEAIQSYEKVVQLAPFCYDARFTLSALLKQQGRHE 489
            .:|.....  |.....|..:..........:.|::::.||:.|.|...|.|..||.|.::.|..|
 Worm   572 QLTKNPCYNNEASGAYWYLKGSLEMMQKHDDLAMEAFNKVLILQPDHIDNRIHLSTLQQKSGFFE 636

  Fly   490 EAVQALE---------QPGEAEGQPLIARLLYERCVMLQQIGRIEEFLDVGYALLSRHSIKLYNR 545
            :|::.||         .|.|        |||..|..:|.:.|..|:|:.:...:|:.|..|:|..
 Worm   637 KALETLENYDLENCSSMPDE--------RLLARRADVLFEAGDSEQFVRITRMMLAPHFYKVYIS 693

  Fly   546 EEMM---AAANGGSAYN--SESLKT-------------IIQMRSKAVDNSAEQDLQDPAKNAASE 592
            .:::   ....|.:...  |.:|||             :::.....|:           .|...:
 Worm   694 PDILKKRRVTKGKTTTPALSNTLKTCAFGVVKHTNWERLVKRLGATVE-----------ANGTFQ 747

  Fly   593 TSDLTVKDEFELFRELVRTAFKHGMHSAAEKICFAMVTTKRFTYYHHEIERIMVLTCYYN--DDC 655
            || |:..|..:...:|:....|...|..|..:|.       :.:.|..:.:...::.:.|  ..|
 Worm   748 TS-LSGTDIHDYCLKLIECLNKMEKHQDALIVCC-------YAFLHPTLFKADKISTFQNLVYFC 804

  Fly   656 AI-------AFSYLR-----ELIAKQPS--------QTTLWNMLSLMIQKGDEVRYYRYMRRLMQ 700
            ||       ||.|:|     .|....|.        |..|:|.::.:......|.|:|::.|.:.
 Worm   805 AIKARCWNLAFEYVRFFHTFSLAVSDPQNGSFSDVLQKRLFNAMNYVFVNSQNVCYHRFIMRALV 869

  Fly   701 RHPVDTKPMRIFQGHYHLNCASFKYALNIYMPILRENP-DPLVALCIAVAFNQLSLQKKVLRKSA 764
            : ..|...::...|:..|...::::|:..|:.:...|. :||:.:.:|:.|..:|.:|.:..:..
 Worm   870 K-AKDNHALQAISGNNSLITGTYRHAMGEYLRVWVANKRNPLICMLLALTFTHMSCKKDLSSRHL 933

  Fly   765 SVAQAVAFGQRYKELRSAGHELADCAAQQEIFYNIGRIYHQANILHLAVDYYEKALAVPVHPLIA 829
            ...:.:||.::|.:.|         |.|||:||||.|::||.:||.||..:|:|.|.|. .|.:.
 Worm   934 IGIRGIAFMKKYSKAR---------ACQQEVFYNIARMFHQMSILPLAKHFYDKVLEVD-PPCVF 988

  Fly   830 EHES----------TLGLQHEVAFNLHLIYRANGNKWKARQYLMRYCVV 868
            :.:.          ...|:...|.||.||||.:||.:.||:...:|.||
 Worm   989 DFDEDGNEVIIPAMKYDLRKMAAHNLALIYRTSGNNFAARKIYEKYLVV 1037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8950	NP_611184.1	BepA	133..268	CDD:443813	37/152 (24%)
		TPR repeat	139..164	CDD:276809	7/24 (29%)
		TPR repeat	169..198	CDD:276809	9/29 (31%)
		TPR repeat	203..231	CDD:276809	7/27 (26%)
		TPR repeat	237..264	CDD:276809	4/26 (15%)
		Spy	318..>515	CDD:443119	50/238 (21%)
		TPR repeat	402..430	CDD:276809	4/31 (13%)
		TPR repeat	435..467	CDD:276809	5/31 (16%)
		LapB	438..702	CDD:442196	64/312 (21%)
		TPR repeat	472..497	CDD:276809	10/33 (30%)
tftc-3	NP_505626.1	TPR	253..>449	CDD:440225	49/200 (25%)
		TPR repeat	253..280	CDD:276809	7/26 (27%)
		TPR repeat	285..315	CDD:276809	9/29 (31%)
		TPR repeat	321..348	CDD:276809	6/26 (23%)
		TPR repeat	354..384	CDD:276809	4/29 (14%)
		TPR repeat	398..422	CDD:276809	5/25 (20%)
		BepA	555..674	CDD:443813	27/126 (21%)
		TPR repeat	579..614	CDD:276809	5/34 (15%)
		TPR repeat	619..643	CDD:276809	8/23 (35%)