DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8950 and gtf3c3

DIOPT Version :10

Sequence 1:NP_611184.1 Gene:CG8950 / 36921 FlyBaseID:FBgn0034186 Length:868 Species:Drosophila melanogaster
Sequence 2:XP_002941839.3 Gene:gtf3c3 / 100488740 XenbaseID:XB-GENE-1217329 Length:880 Species:Xenopus tropicalis


Alignment Length:906 Identity:272/906 - (30%)
Similarity:436/906 - (48%) Gaps:117/906 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 SNEVLIEEIDSNDVPENELEQFQETEPLRV-VDIIDCDTDGERRCIADDEEEGALIKRYVQGVQC 69
            |...|.|.:.||:..|.|..........|. ..:|.   :|:|....|||||             
 Frog    47 SGGTLPEAVASNEEEEEETSDGVSKSVHRAFASMIG---EGDRTGDDDDEEE------------- 95

  Fly    70 LEFPDFCTKLEASDEDEEGNDEEPSEAAGSIEKPNTSAQAKTSQEQSTGSGRSGGGGFRKSQLST 134
                          |:||..:||.......::.|:.........|.:..:.:.......:|:|..
 Frog    96 --------------EEEEEEEEEEEHGEHQVQPPSAGDVFALEMELNRENKKMMREKRPRSKLPK 146

  Fly   135 ALQGLMGEANLSFVYGRYETAERICMEIIRQNPLASEPFYTLAEIYENR-DEVKFLNFSTLAAHL 198
            .|:|||||||:.|..|..|.|..:|||||||.|||.|||.|||.|||:: |..|.|.|..:||||
 Frog   147 VLRGLMGEANIRFARGESEEAILMCMEIIRQAPLAYEPFSTLAMIYEDQGDMEKSLQFELIAAHL 211

  Fly   199 NPQDRDMWIRVSDLLVQQGNLARARLIYTKAIKMLPKVYQLRLRKAQLLQKMGETNASMFTYLKM 263
            ||.:.:.|:|::::.::|.|:.:|...|.||::..|...:....::.|.:::||...:|..|.::
 Frog   212 NPSNTEEWVRLAEMSLEQDNIKQAIFCYGKALRYNPTNVRFLWERSSLYEQIGEHKLAMDGYRRI 276

  Fly   264 LPLMPPDEWKMCLNTAKNVARYFHVLEKHSLALEAMEGAYSVCGARFTLEDINIYLELLILNKQY 328
            |.|:.|.:.:..:..|:::|:.::.....:.|:..:|.|.|.......:||:||..||.:.||||
 Frog   277 LNLLSPTDGERFMQLARDMAKTYYETNDIASAIGTIEEALSKHQNLVAIEDVNIAAELYLSNKQY 341

  Fly   329 AKVLRCLRERTNFEL---ENDQEESLELIYFCEIPDDYVPELRAKLCVSLIHMR----AHHLLGY 386
            .|.|..:.:.:...|   |.|...|.|.: .|.|||....::..|:.:.|||:.    .:.||.:
 Frog   342 DKALDVITQFSGITLSKSETDVLNSAESV-VCHIPDGVPIDITVKMMLCLIHLNILEPVYPLLTF 405

  Fly   387 LIQNVQEHITLTADRVELYMDITEALMQEHKYAEAIALMSPITDGDTVECP-----AFVWLRQAE 446
            |::...|.:.      :||:|:.||.:...:|..|:.|:|.:.      |.     |.||||.|:
 Frog   406 LMEQNPEEVG------DLYLDVAEAFLDVGEYNSALPLLSALV------CSLKYNLAVVWLRHAD 458

  Fly   447 CLRQLNRTNEAIQSYEKVVQLAPFCYDARFTLSALLKQQGRHEEAVQALE---------QPGEAE 502
            ||:.|....:|.:||.|||.:||...|||.:||.|.:|.|..|:|::|||         |...|.
 Frog   459 CLKALGHMEKAAESYSKVVDMAPLHLDARISLSTLQQQLGHPEKALEALEPMYDPDTLAQDSNAA 523

  Fly   503 GQPLIARLLYERCVMLQQIGRIEEFLDVGYALLSRHSIKLYNREEMMAAANGGSAYNSESLKTII 567
            .|.|  :||..|..:|...|::.:::|....:|:.......||.::...:      :|:|.:..:
 Frog   524 QQEL--KLLLHRSTLLFSQGKLYDYVDTLLTMLAMLLKIAMNRAQVCLIS------SSKSGERHL 580

  Fly   568 QMRSKAVDNSAEQDLQDPAKNAASE-----TSDLTVKDEFELFRELVRTAFKHGMHSAAEKICFA 627
            .:...:.|..:..|.||.|.:....     ||.||..|.:.|   ||:|....|..|..::.  .
 Frog   581 YLLKVSRDKMSNNDDQDVANSDGKSIFTVLTSVLTKDDWWSL---LVKTVLALGDLSRFKEA--E 640

  Fly   628 MVTTKRFTYY--------HHEIERIMVLTCYYNDDCAI-------AFSYLRELIAKQPSQTTLWN 677
            ::......||        ..|:|       |:....||       |::|:|.::.:..::..|||
 Frog   641 LLVDSSLEYYSFYDDRMKRKELE-------YFGLSAAILDKNFRKAYNYIRIMLMENVNKPQLWN 698

  Fly   678 MLSLMIQKGDEVRYYRYMRRLMQRHPVDTKPMRIFQGHYHLNCASFKYALNIYMPILR-ENPDPL 741
            :.:.:.....:||::|:..|||.::| ....:.:..||......|||:||..|:...| |..|||
 Frog   699 IFNQITMHSQDVRHHRFCLRLMLKNP-SNLALCVLSGHNAFVSGSFKHALAQYVQAFRMEMNDPL 762

  Fly   742 VALCIAVAFNQLSLQKKVLRKSASVAQAVAFGQRYKELRSAGHELADCAAQQEIFYNIGRIYHQA 806
            .:|||.:.|..::.||.||::.|.:.|..:|..||.:||      ..|   ||.:||:||..||.
 Frog   763 HSLCIGLTFVHMASQKFVLKRHALLVQGFSFLNRYLKLR------GPC---QESYYNMGRALHQM 818

  Fly   807 NILHLAVDYYEKALAVPVHPLIAEHESTLGLQHEVAFNLHLIYRANGNKWKARQYLMRYCV 867
            .::|||:.||::||.:|...|.......|.|:.::||||.|||:.:||...||:.|.:|||
 Frog   819 GLVHLAIHYYQQALELPPLELEGMELDQLDLRRDIAFNLSLIYQNSGNLEMARRLLHQYCV 879

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8950NP_611184.1 BepA 133..268 CDD:443813 57/135 (42%)
TPR repeat 139..164 CDD:276809 14/24 (58%)
TPR repeat 169..198 CDD:276809 16/29 (55%)
TPR repeat 203..231 CDD:276809 8/27 (30%)
TPR repeat 237..264 CDD:276809 5/26 (19%)
Spy 318..>515 CDD:443119 71/217 (33%)
TPR repeat 402..430 CDD:276809 9/27 (33%)
TPR repeat 435..467 CDD:276809 16/36 (44%)
LapB 438..702 CDD:442196 80/292 (27%)
TPR repeat 472..497 CDD:276809 13/33 (39%)
gtf3c3XP_002941839.3 TPR repeat 151..176 CDD:276809 14/24 (58%)
LapB <155..350 CDD:442196 70/194 (36%)
TPR repeat 182..210 CDD:276809 14/27 (52%)
TPR repeat 215..245 CDD:276809 8/29 (28%)
TPR repeat 250..277 CDD:276809 5/26 (19%)
TPR repeat 285..317 CDD:276809 5/31 (16%)
BepA <406..508 CDD:443813 40/113 (35%)
TPR repeat 416..444 CDD:276809 9/33 (27%)
TPR repeat 449..479 CDD:276809 15/29 (52%)
TPR repeat 484..508 CDD:276809 11/23 (48%)
Spy 793..>878 CDD:443119 37/93 (40%)
TPR repeat 804..834 CDD:276809 16/32 (50%)
TPR repeat 839..876 CDD:276809 15/36 (42%)

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