DRSC/TRiP Functional Genomics Resources

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Protein Alignment fat-spondin and Spon1

DIOPT Version :10

Sequence 1:NP_477435.1 Gene:fat-spondin / 36919 FlyBaseID:FBgn0026721 Length:763 Species:Drosophila melanogaster
Sequence 2:NP_742064.2 Gene:Spon1 / 64456 RGDID:619918 Length:807 Species:Rattus norvegicus


Alignment Length:764 Identity:246/764 - (32%)
Similarity:355/764 - (46%) Gaps:130/764 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 GRRTRGDNGYKLIVADGPNGYVPGKTYNLLLLGSRTHLKVQHFTHFTITA--EAHTGARRPQAAS 97
            |.|..|...:.|.|...|:.|.||.:|.:.|..:    ...:|..||:.|  |...|.:....| 
  Rat    52 GTRREGYTEFSLRVEGDPDFYKPGSSYRVTLSAA----PPSYFRGFTLIALKENREGDKEEDHA- 111

  Fly    98 PRRVGRFQLFSDSLTQFNDRCVNTVSEADDLPKTEVQVMWVAPESGSGCVSLSAMVYEGPRAWFA 162
                |.||:..:..|||...|...|:|:....:|.:||.|:||.:|:|||.|.|.:.:....:|.
  Rat   112 ----GTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVFWIAPPTGTGCVILKASIVQKRIIYFQ 172

  Fly   163 DDGNLSTVICERKP--DAAAAQK--ECCACDEAKYSFVFEGIWSNETHPKDYPFAIWLTHFSDVI 223
            |:|:|:..:||:.|  |....:.  :||||..|||...|.|.||.:|||||||..  ..|:|.:|
  Rat   173 DEGSLTKKLCEQDPTLDGVTDRPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRR--ANHWSAII 235

  Fly   224 GASHESNFSFWGENHIATAGFRSLAEWGSPAALETELRANGPKLRTLIKAAG---LWYP-NVNQN 284
            |.||..|:..|.....|:.|.:.:||.|||..:|.|:|....::.|:|||..   .|.| ||...
  Rat   236 GGSHSKNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQPVNVRAA 300

  Fly   285 TSSKFRVDRKHPKVSLVSMFGPSPDWVVGISGLDLCTEDCSWKESMDFDLFPWDAGTDSGISYMS 349
            .|::|.|||....:|.::|.||||||.||:|..||||::|.|.:.:..||.|||||||||::|.|
  Rat   301 PSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSGVTYES 365

  Fly   350 PNSETQPPERMYRITTMYPEDPRAPFYNPKSREMTPLAKLYLRRE-------KIVSRNCDDEFLQ 407
            ||..|.|.|::..:|::  :.|::|||:|:...:|.:|::.:.|.       .||..|.||....
  Rat   366 PNKPTIPQEKIRPLTSL--DHPQSPFYDPEGGSITQVARVVIERIARKGEQCNIVPDNVDDIVAD 428

  Fly   408 ALQLEVSDDAEEQDTRAECRVGDYSAWSPCSVS-CGKGIRMRSRQYLYPAAADQNKCARQLVAKE 471
            .    ..::.:|.||...|...::|.||.||.| |.||.|||.|                 :.|.
  Rat   429 L----APEEKDEDDTPETCIYSNWSPWSACSSSTCEKGKRMRQR-----------------MLKA 472

  Fly   472 MCVAAIPECAD--------GPAQSKDRDDDEGENLANSQSLVGSNGEGAGLCKTSPWSVWSECSA 528
            ....::| |.|        ||                     |.:.|....|..|.|..||.||.
  Rat   473 QLDLSVP-CPDTQDFQPCMGP---------------------GCSDEDGSTCTMSEWITWSPCSV 515

  Fly   529 SCGIGITMRTRTFVNHLGRKRCPHITIVEKNKCMRP-----DCTYEQVELPDPQCPTSQWSDWSP 588
            |||:|:..|.| :|     |:.|.    :.:.||.|     .||..: |.....|..::|.:|..
  Rat   516 SCGMGMRSRER-YV-----KQFPE----DGSVCMLPTEETEKCTVNE-ECSPSSCLVTEWGEWDD 569

  Fly   589 CSSTCGRGVTIRTRLLLLENGPDKESCTQRMELHQQKECVNPIDCHINAEQAKDICVQAP--DPG 651
            ||:|||.|:..|.|::.: :..|...|  :.|..|.::|:.| :||...      |:.:|  :..
  Rat   570 CSATCGMGMKKRHRMVKM-SPADGSMC--KAETSQAEKCMMP-ECHTIP------CLLSPWSEWS 624

  Fly   652 PCRGTYMRYAYDPQNQHCYSFTYGGCRGNRNNFLTENDCLNTCN--VLRSPYSSRVDQPRACVLS 714
            .|                 |.|.|.....|...|.....|..||  :.::......:.|..|.||
  Rat   625 DC-----------------SVTCGKGMRTRQRMLKSLAELGDCNEDLEQAEKCMLPECPIDCELS 672

  Fly   715 DWSVWSPCSVSCGVGVSESRRYVVTEPQNGGQPCSKRLVKSRSCAMPAC 763
            :||.||.|:.|||.|.....|.:..|||.||.||.: .|:.:.|....|
  Rat   673 EWSQWSECNKSCGKGHMIRTRTIQMEPQFGGAPCPE-TVQRKKCRARKC 720

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fat-spondinNP_477435.1 Reeler 24..172 CDD:260081 43/138 (31%)
Spond_N 191..385 CDD:461924 86/197 (44%)
PTZ00441 <419..>497 CDD:240420 23/86 (27%)
TSP1_spondin 426..>463 CDD:480609 14/37 (38%)
TSP1_spondin 515..566 CDD:480609 19/55 (35%)
TSP1_spondin 578..630 CDD:480609 16/51 (31%)
Kunitz-type 644..695 CDD:444694 9/52 (17%)
TSP1_spondin 711..763 CDD:465948 22/51 (43%)
Spon1NP_742064.2 Reeler 43..182 CDD:260081 43/138 (31%)
Spond_N 205..397 CDD:461924 86/195 (44%)
TSP1_spondin 443..494 CDD:465948 20/89 (22%)
TSP_1 505..554 CDD:459668 20/59 (34%)
TSP_1 562..610 CDD:459668 16/51 (31%)
TSP_1 618..665 CDD:459668 10/63 (16%)
TSP1_spondin 669..720 CDD:465948 22/51 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 732..752
TSP1_spondin 755..807 CDD:465948
Blue background indicates that the domain is not in the aligned region.

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