DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fat-spondin and spon2b

DIOPT Version :9

Sequence 1:	NP_477435.1	Gene:	fat-spondin / 36919	FlyBaseID:	FBgn0026721	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_571083.4	Gene:	spon2b / 30202	ZFINID:	ZDB-GENE-990415-161	Length:	331	Species:	Danio rerio

Alignment Length:	300	Identity:	98/300 - (32%)
Similarity:	152/300 - (50%)	Gaps:	17/300 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 CCACDEAKYSFVFEGIWSNETHPKDYPFAIWLTHFSDVIGASHESNFSFWGENHIATAGFRSLAE 249
            |.|...|||...|.|.|:....||.||.......:|.:||.:|.|::..|..|..|:.|.|..:|
Zfish    34 CTAPSTAKYRLTFTGQWTQTAFPKHYPLYRPPAQWSPLIGVTHSSDYHLWQRNEYASNGVREFSE 98

  Fly   250 WGSPAALETELRANGPKLRTLIKAAGLW-YPNVNQNT---SSKFRVDRKHPKVSLVSMFGPSPDW 310
            ......|..|:.|.|.:::::.   ||: .|.|...|   :::|.|..:|..:|.:....|||||
Zfish    99 RAEAWTLIKEVEAAGERIQSVY---GLFSAPAVVAGTGHATTEFEVFARHSLLSFIVRIVPSPDW 160

  Fly   311 VVGISGLDLCTEDCSWKESMDFDLFPWDAGTDSGISYMSPNSETQPPERMYRITTMYPEDPRAPF 375
            .:|:..|:||..| .|||::..:|:|:|||||||.::.|||.||.|.:::.:||:.:|..|...|
Zfish   161 FIGVDSLNLCEGD-HWKENISLELYPYDAGTDSGFTFSSPNFETIPQDKVTQITSSFPSHPANSF 224

  Fly   376 YNPKSREMTPLAKLYLRREKIVSRNCDDEFLQALQLEVSDDAEEQD-----TRAECRVGDYSAWS 435
            |.|:.:.:.|:||:.|  .||.:.......:|..|........|.|     |..:|.|..:|.|.
Zfish   225 YYPRLKHLPPIAKVSL--TKIKNNQIFSLPIQPTQSNQIPSGNEIDGPLINTPLDCEVSVWSPWG 287

  Fly   436 PCSVSCG-KGIRMRSRQYLYPAAADQNKCARQLVAKEMCV 474
            .|...|| ||::.|:| |::...|:.......|..|.:|:
Zfish   288 LCKGQCGEKGVKHRTR-YIHTHPANNGAPCPSLEEKRLCI 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fat-spondin	NP_477435.1	Reeler	24..172	CDD:260081
		Spond_N	191..378	CDD:283999	68/190 (36%)
		TSP1	428..473	CDD:214559	14/45 (31%)
		TSP1	518..566	CDD:214559
		TSP1	581..627	CDD:214559
		Kunitz_BPTI	643..694	CDD:278443
		TSP1	714..763	CDD:214559
spon2b	NP_571083.4	Spond_N	40..227	CDD:283999	68/190 (36%)
spon2b	NP_571083.4	TSP1	280..330	CDD:214559	15/47 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920