Protein Alignment fat-spondin and THSD7A

DIOPT Version :10

• Sequence 1: NP_477435.1
• Gene: fat-spondin / 36919
• FlyBaseID: FBgn0026721
• Length: 763
• Species: Drosophila melanogaster
• Sequence 2: NP_056019.1
• Gene: THSD7A / 221981
• HGNCID: 22207
• Length: 1657
• Species: Homo sapiens
• Alignment Length: 868
• Identity: 183/868 - (21%)
• Similarity: 267/868 - (30%)
• Gaps: 352/868 - (40%)

  Fly   118 CVNTVSEADD------------------LPKTEVQVMWVAPESGSGCV-SLSAMVYEGPR----- 158
            |:|:..|..|                  .||..|...|   .:.|.|. :.|....||.:
Human   603 CINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTW---STWSSCSHTCSGKTTEGKQIRARS 664

  Fly   159 --AWFADDGNLSTVICERKPDAAAAQKECCACDEAKYSFVFEGIWSNETHPKDYPFAI--WLTHF 219
              |:..::|.:      |.|:::|.| |..:|:|                   :|..:  |.|
Human   665 ILAYAGEEGGI------RCPNSSALQ-EVRSCNE-------------------HPCTVYHWQT-- 701

  Fly   220 SDVIGASHESNFSFWGE--NHIATAGFRSLAEWGSPAA----LETE----LRAN----GPK---- 266
                        ..||:  ...:.:.|.:...|...|:    ::|.    :|.|    |||
Human   702 ------------GPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPE 754

  Fly   267 -LR--------------TLIKAAGLW--YPNVNQNTSSKFRVDRKHPKVSLVSMFGPSPDWVVGI 314
             ||              .::.....|  .|:..:...|..|...:|..:..:...|
Human   755 SLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANG--------- 810

  Fly   315 SGLDLCTED------------CS---WK--ESMDFDLFPWDAGTDSGISYMSPNS-ETQPPERMY 361
             |.| ||:.            |.   ||  :.....|.||....|      ||.: |...|.|..
Human   811 -GRD-CTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQD------SPGAQEGCGPGRQA 867

  Fly   362 RITTMYPEDPRAPFYNPKSREMTPLAKLYLRREKIVSRNCDDEFLQALQLEVSDDAEEQDTRAEC 426
            |..|...:|......:...:...|:..|                .||.|:...||         |
Human   868 RAITCRKQDGGQAGIHECLQYAGPVPAL----------------TQACQIPCQDD---------C 907

  Fly   427 RVGDYSAWSPCSVSCGKGIRMRSR--------------QYLYPAAADQ----NKCARQLVAK-EM 472
            ::..:|.:|.|:..|| .:|.|.|              .:|||....|    :|...|.|.. ..
Human   908 QLTSWSKFSSCNGDCG-AVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSD 971

  Fly   473 CV---------------AAIPECADGPAQSKDRDDDEGENLANSQSLVGSNG--EGAGL------ 514
            |:               ..|.||..|.........|:...|..: |...|:|  |.|.:
Human   972 CILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVET-SRCNSHGYIEEACIIPCPSD 1035

  Fly   515 CKTSPWSVWSECSASCGIGITMRTR---------------------------------------- 539
            ||.|.||.||.||.|||.|:.:|::
Human  1036 CKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWV 1100

  Fly   540 ---------TFVNHLGRKRCPHITIVEKNKCMR--PDCTYEQVE-----------------LPDP 576
                     ||||.  |:.|.......|.:||:  .|...|.||                 ||.|
Human  1101 TEPWSICKVTFVNM--RENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCP 1163

  Fly   577 Q-CPTSQWSDWSPCSSTCGRGVTIRTRLLLLENGPDKESCTQRMELHQQKECVNPIDCHINAEQA 640
            : |..|:|..|:.|...|                 ::.|..||        ..:||  ...|::.
Human  1164 EDCVISEWGPWTQCVLPC-----------------NQSSFRQR--------SADPI--RQPADEG 1201

  Fly   641 KDICVQAPDPGPCRGTYMRYAYDPQNQHCYSFTY-----GGCR---------GNRNNFLTENDC- 690
            :. |..|.:..||.          .|::||.:.|     ..|:         |.:...|   ||
Human  1202 RS-CPNAVEKEPCN----------LNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRML---DCV 1252

  Fly   691 --------LNTCNVL------RSPYSSRVDQPRACVLSDWSVWSPCSVSCGVGVSESRRYVVTEP 741
                    |..|..|      :...|..|:.|..|.|||||.||.||.:||:.....||..||:|
Human  1253 RSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQP 1317

  Fly   742 -QNGGQPCSKRLVKSRSCAMPAC 763
             |..|:||...:.:|:.|.:..|
Human  1318 FQGDGRPCPSLMDQSKPCPVKPC 1340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fat-spondin	NP_477435.1	Reeler	24..172	CDD:260081	15/79 (19%)
		Spond_N	191..385	CDD:461924	41/248 (17%)
		PTZ00441	<419..>497	CDD:240420	22/111 (20%)
		TSP1_spondin	426..>463	CDD:480609	13/54 (24%)
		TSP1_spondin	515..566	CDD:480609	23/101 (23%)
		TSP1_spondin	578..630	CDD:480609	9/51 (18%)
		Kunitz-type	644..695	CDD:444694	14/73 (19%)
		TSP1_spondin	711..763	CDD:465948	23/52 (44%)
THSD7A	NP_056019.1	TSP1_spondin	195..246	CDD:465948
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	265..311
		TSP1_spondin	361..412	CDD:465948
		TSP1_spondin	513..573	CDD:480609
		TSP1_ADAMTS	699..767	CDD:465950	15/81 (19%)
		TSP1_spondin	772..828	CDD:480609	10/66 (15%)
		TSP1_spondin	1036..>1076	CDD:465948	14/39 (36%)
		TSP1_ADAMTS	1099..1161	CDD:465950	13/63 (21%)
		TSP1_spondin	1166..1217	CDD:480609	16/88 (18%)
		TSP1_spondin	1287..1340	CDD:465948	23/52 (44%)
		TSP1_spondin	1415..1474	CDD:480609
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1570..1591