DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fat-spondin and Spon2

DIOPT Version :9

Sequence 1:	NP_477435.1	Gene:	fat-spondin / 36919	FlyBaseID:	FBgn0026721	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_612542.1	Gene:	Spon2 / 171569	RGDID:	708584	Length:	330	Species:	Rattus norvegicus

Alignment Length:	288	Identity:	103/288 - (35%)
Similarity:	143/288 - (49%)	Gaps:	15/288 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 CCACDEAKYSFVFEGIWSNETHPKDYPFAIWLTHFSDVIGASHESNFSFWGENHIATAGFRSLAE 249
            |.|...|:||..|.|.||....||.||.......:|.::||:|.|::|.|.:|...:.|.|..||
  Rat    34 CTARPLARYSITFTGKWSQTAFPKQYPLFRPPAQWSSLLGAAHSSDYSMWRKNEYVSNGLRDFAE 98

  Fly   250 WGSPAALETELRANGPKLRT---LIKAAGLWYPNVNQNTSSKFRVDRKHPKVSLVSMFGPSPDWV 311
            .|...||..|:.|.|.||::   :..|..:  |:....||::..|..:|..||.|....|||||.
  Rat    99 RGEAWALMKEIEAAGEKLQSVHAVFSAPAV--PSGTGQTSAELEVHPRHSLVSFVVRIVPSPDWF 161

  Fly   312 VGISGLDLCTEDCSWKESMDFDLFPWDAGTDSGISYMSPNSETQPPERMYRITTMYPEDPRAPFY 376
            |||..|||| |...|||.:..||:|.|||||||.::.|||..|.|.:.:..||...|..|...||
  Rat   162 VGIDSLDLC-EGGRWKEQVVLDLYPHDAGTDSGFTFSSPNFATIPQDTVTEITASSPSHPANSFY 225

  Fly   377 NPKSREMTPLAKLYLRREKIVSR-----NCDDEFLQALQLEVSDDAEEQDTRAECRVGDYSAWSP 436
            .|:.:.:.|:||:...|.:...|     :.|   |.:...|:.|.....:|..:|.|..:|:|..
  Rat   226 YPRLKSLPPIAKVTFVRLRQSPRAFAPPSLD---LASRGNEIVDSLSVPETPLDCEVSLWSSWGL 287

  Fly   437 CSVSCGK-GIRMRSRQYLYPAAADQNKC 463
            |...||| |.:.|:|......|.:...|
  Rat   288 CGGPCGKLGAKSRTRYVRVQPANNGTPC 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fat-spondin	NP_477435.1	Reeler	24..172	CDD:260081
		Spond_N	191..378	CDD:283999	77/189 (41%)
		TSP1	428..473	CDD:214559	12/37 (32%)
		TSP1	518..566	CDD:214559
		TSP1	581..627	CDD:214559
		Kunitz_BPTI	643..694	CDD:278443
		TSP1	714..763	CDD:214559
Spon2	NP_612542.1	Spond_N	40..227	CDD:283999	77/189 (41%)
Spon2	NP_612542.1	TSP1	279..329	CDD:214559	12/37 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3539
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820