DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fat-spondin and SPON2

DIOPT Version :9

Sequence 1:	NP_477435.1	Gene:	fat-spondin / 36919	FlyBaseID:	FBgn0026721	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_001121797.2	Gene:	SPON2 / 10417	HGNCID:	11253	Length:	331	Species:	Homo sapiens

Alignment Length:	333	Identity:	111/333 - (33%)
Similarity:	156/333 - (46%)	Gaps:	39/333 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 ERKPDAAAAQKECCA------------------CDE---AKYSFVFEGIWSNETHPKDYPFAIWL 216
            |....|||..|..||                  |..   ||||..|.|.||....||.||.....
Human     2 ENPSPAAALGKALCALLLATLGAAGQPLGGESICSARALAKYSITFTGKWSQTAFPKQYPLFRPP 66

  Fly   217 THFSDVIGASHESNFSFWGENHIATAGFRSLAEWGSPAALETELRANGPKLRT---LIKAAGLWY 278
            ..:|.::||:|.|::|.|.:|...:.|.|..||.|...||..|:.|.|..|::   :..|..:
Human    67 AQWSSLLGAAHSSDYSMWRKNQYVSNGLRDFAERGEAWALMKEIEAAGEALQSVHAVFSAPAV-- 129

  Fly   279 PNVNQNTSSKFRVDRKHPKVSLVSMFGPSPDWVVGISGLDLCTEDCSWKESMDFDLFPWDAGTDS 343
            |:....||::..|.|:|..||.|....|||||.||:..||||..| .|:|....||:|:||||||
Human   130 PSGTGQTSAELEVQRRHSLVSFVVRIVPSPDWFVGVDSLDLCDGD-RWREQAALDLYPYDAGTDS 193

  Fly   344 GISYMSPNSETQPPERMYRITTMYPEDPRAPFYNPKSREMTPLAKLYLRREKIVSRNCDDEF--- 405
            |.::.|||..|.|.:.:..||:..|..|...||.|:.:.:.|:|::.|.|    .|.....|
Human   194 GFTFSSPNFATIPQDTVTEITSSSPSHPANSFYYPRLKALPPIARVTLVR----LRQSPRAFIPP 254

  Fly   406 ---LQALQLEVSDDAEEQDTRAECRVGDYSAWSPCSVSCGK-GIRMRSRQYLYPAAADQNKCARQ 466
               |.:...|:.|.|...:|..:|.|..:|:|..|...||: |.:.|:| |:....|:......:
Human   255 APVLPSRDNEIVDSASVPETPLDCEVSLWSSWGLCGGHCGRLGTKSRTR-YVRVQPANNGSPCPE 318

  Fly   467 LVAKEMCV 474
            |..:..||
Human   319 LEEEAECV 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fat-spondin	NP_477435.1	Reeler	24..172	CDD:260081
		Spond_N	191..378	CDD:283999	76/189 (40%)
		TSP1	428..473	CDD:214559	12/45 (27%)
		TSP1	518..566	CDD:214559
		TSP1	581..627	CDD:214559
		Kunitz_BPTI	643..694	CDD:278443
		TSP1	714..763	CDD:214559
SPON2	NP_001121797.2	Spond_N	41..228	CDD:399462	76/189 (40%)
SPON2	NP_001121797.2	TSP1_spondin	278..330	CDD:408798	15/50 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3539
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820