Protein Alignment SmydA-6 and SMYD2

DIOPT Version :10

• Sequence 1: NP_611182.1
• Gene: SmydA-6 / 36917
• FlyBaseID: FBgn0034183
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_064582.2
• Gene: SMYD2 / 56950
• HGNCID: 20982
• Length: 433
• Species: Homo sapiens
• Alignment Length: 465
• Identity: 102/465 - (21%)
• Similarity: 174/465 - (37%)
• Gaps: 105/465 - (22%)

  Fly    21 GRFAVALCNVRAGETLLLENPIVVLPL-MGER--RCSKCFNLTE--SFCRKCRLLALCE-DCSDH 79
            ||...||...:.|: ||...|.....| :.||  .|..||...|  |.|.:|:....|. :|...
Human    18 GRGLRALQPFQVGD-LLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKE 81

  Fly    80 D----ERDCKRLAEM--NFSDDQVE------LLQKKEHTEIQPVLKCLLLREHEETLPLYEEMSQ 132
            |    :.:|..:...  |::..:..      |.::|.|.|..|..|.|.::|.|..|   :::..
Human    82 DWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHL---DKLDN 143

  Fly   133 MDSQLMTRRGTEVWKNYQEHAFTPLDYGGVLAQLRGAADEDLVQGLLGILDINAYEIRAPEVGGA 197
            ....|:......:...|.:|.              |..|.|.:..|...::.|.:.|...|:...
Human   144 EKKDLIQSDIAALHHFYSKHL--------------GFPDNDSLVVLFAQVNCNGFTIEDEELSHL 194

  Fly   198 MRGLYRRAGLFAHSCTPNLVISIDDEQRIKVYANRFIAAGEILYNCYTNVLLGTEERRKILKVGK 262
            ...::....|..|||.||::::... ...:|.|.:.|..||.::..|.::|..||:|...|:...
Human   195 GSAIFPDVALMNHSCCPNVIVTYKG-TLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSY 258

  Fly   263 CFDCSCPRC----QDPTELGTHMSSFICSQCSCVDGYIVRQPDTGIWQCLLNPEHTLKQEFVSNM 323
            .|.|.|..|    :|..::.                  :|:        |.:|.   |.|.:.:|
Human   259 FFTCECQECTTKDKDKAKVE------------------IRK--------LSDPP---KAEAIRDM 294

  Fly   324 LERAK---EEIFHARDDIYRQ--------ELLLAKLSRLLHRNHFLMLDLKQNIASILRQILQNM 377
            :..|:   ||...|:.  |:.        ||...|:|.:...::..||.:          :.|.|
Human   295 VRYARNVIEEFRRAKH--YKSPSELLEICELSQEKMSSVFEDSNVYMLHM----------MYQAM 347

  Fly   378 GTRPNKKVYERKIRLCQEILLVLKVVTPGISRLKAIALYEL--ANTQAELARKMYTEMEHSANDL 440
            |.....:.:|..::..|      |::.|   ..|...||.|  |:...:|.| :|..:||.|...
Human   348 GVCLYMQDWEGALQYGQ------KIIKP---YSKHYPLYSLNVASMWLKLGR-LYMGLEHKAAGE 402

  Fly   441 LAELERVEVM 450
            .|..:.:.:|
Human   403 KALKKAIAIM 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-6	NP_611182.1	SET_SMYD	<185..271	CDD:380997	23/85 (27%)
SMYD2	NP_064582.2	SET_SMYD2	7..269	CDD:380979	64/269 (24%)
		zf-MYND	52..90	CDD:460312	10/37 (27%)