DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SmydA-6 and smyd1b

DIOPT Version :9

Sequence 1:	NP_611182.1	Gene:	SmydA-6 / 36917	FlyBaseID:	FBgn0034183	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001034725.1	Gene:	smyd1b / 569027	ZFINID:	ZDB-GENE-060522-1	Length:	486	Species:	Danio rerio

Alignment Length:	564	Identity:	120/564 - (21%)
Similarity:	199/564 - (35%)	Gaps:	174/564 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EIKQNDTLGRFAVALCNVRAGETLLLENPI--VVLPLMGERRCSKCFNLTESF--CRKCRLLALC 73
            |:..:...||...|.....||:.|..|.|.  ||........|..||...|..  |.:||....|
Zfish     5 EVFDSPGKGRGLRATKEAWAGDVLFAEPPFASVVFDSQASSICHSCFRRQEKLQRCGQCRFAQYC 69

  Fly    74 EDCSDHDERDCKRLAEMNFSDDQVELLQKKEHTEIQPVLKCLLLREH----EETLPL-------Y 127
                   ::.|:|..             .:||.     |:|..::.:    .|.:.|       .
Zfish    70 -------DKTCQRAG-------------WEEHK-----LECAAIKTYGKPPSENVRLAARILWRM 109

  Fly   128 EEMSQM--DSQLMTRRGTE---------VWKNYQEHAFTPLDYGGVLAQLRGAADE--DLVQGLL 179
            ::...:  |:||.|....|         ..|:::......|||..     |.:...  |.|..:|
Zfish   110 DKQGSVVSDNQLTTLEDLEDHICDISEDDLKDFKVDIHNFLDYWP-----RNSKPHTVDSVSHIL 169

  Fly   180 GILDINAYEI---RAPEVGGAMRGLYRRAGLFAHSCTPNLVISIDD------------EQRIKVY 229
            |:::.|.:.:   |..:..|.  ||:....|..|.|.||..:.:::            ::||::.
Zfish   170 GVINCNGFMVSDQRGLQAVGV--GLFPNLCLVNHDCWPNCTVILNNGNQSAIDTVFHSQKRIELR 232

  Fly   230 ANRFIAAGEILYNCYTNVLLGTEERRKILKVGKCFDCSCPRCQDPTELGTHMSSFICSQCSCVDG 294
            |...|:|||.:...|.:.|..:.:|:::||....|||:|..|.:..:....|:.      :.|||
Zfish   233 ALGKISAGEEVTVAYVDYLNVSADRQRLLKQQYFFDCTCKHCTEKIKDDLKMAG------AEVDG 291

  Fly   295 YIVRQPDTGIWQCLLNPEHTLKQ--EFVSNMLERAKEEIFHA---------RDDIYRQELLLAKL 348
            ..|             ||..:|:  ||....||:.::....|         |:.:.:||.:||.
Zfish   292 VKV-------------PEEQVKEVTEFSRQKLEKMEKARIEANYNEVVKICRECVEKQENVLAD- 342

  Fly   349 SRLLHRNHFLMLDLKQNIASILRQILQNMGTRPNKKVYERKIRLCQEILLVLKVVTPGISRL--- 410
                  .|...|    .:...|.::|..:........|.||:     :...||:..|..::|
Zfish   343 ------THIYYL----RVCCTLSEVLSYLQFFDEASEYARKM-----VDGYLKLYHPNNAQLGMA 392

  Fly   411 ----------------------KAIALYELAN------TQAELARKMYTEME---HSANDLLAEL 444
                                  ||.|:..:.:      |:...|.:|.||||   ...|:.:...
Zfish   393 TMRAGVTHWQAGFIEVAHGMICKAFAILMITHGPTHPITKDLEAMRMQTEMELRMFQQNEYVYHS 457

  Fly   445 ERVEVMLRESLRMLLFEPLATPEGQLTRSMLRELKELQDDIKNL 488
            .|...:..:.:||:. ||  |.||                ||||
Zfish   458 MREAALKNQPMRMMA-EP--TNEG----------------IKNL 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-6	NP_611182.1	SET	<179..244	CDD:279228	19/79 (24%)
smyd1b	NP_001034725.1	zf-MYND	47..85	CDD:280009	13/62 (21%)
smyd1b	NP_001034725.1	SET	<173..247	CDD:214614	17/75 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D981799at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820