DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SmydA-6 and Smyd4-1

DIOPT Version :9

Sequence 1:	NP_611182.1	Gene:	SmydA-6 / 36917	FlyBaseID:	FBgn0034183	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_610500.2	Gene:	Smyd4-1 / 35985	FlyBaseID:	FBgn0033427	Length:	751	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	112/546 - (20%)
Similarity:	195/546 - (35%)	Gaps:	150/546 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GRFAVALCNVRAGETLLLENPIVVLPLMGERRCSKCFNLTES-------------FC-RKCRLL- 70
            ||:.||...:..|..:..|.....:||.....|.:|.....|             :| ||||..
  Fly   226 GRYMVAKEAISKGNVIFSERASCFVPLEQLLICQQCAATLMSAPIPCPNCHQRVVYCSRKCREAH 290

  Fly    71 -ALCE-DCSDHDERDCKR----------------------LAEMNFS----DDQVELLQKKEHTE 107
             |:.: :|:.: .:|..|                      |.||..:    ::.:.|.:|.|.:|
  Fly   291 SAIHKFECAAY-RKDILRLLGISHLALRLLLTYIPYIRPHLQEMTSAKGMWEEIMNLSRKPEESE 354

  Fly   108 IQPVLKCLLLREHEETLPLYEEMSQMDS----------------QLMTRRGTEVWKNYQEHAFTP 156
            ..|           |.|.....:||:|.                ||..:..|:.:..:.....:.
  Fly   355 NAP-----------EYLRSLRMVSQLDQAIDEELNYHILCANLLQLYLKEHTDFYDQFHSLPASI 408

  Fly   157 LDYGGVLAQ--LRGA----ADEDLVQGLLGI-LDINAYEIRAPEVGGAMRGLYR----------- 203
            .|:..:::.  ||.|    |:..:...|||: ::...:.:..||:....|.|.|
  Fly   409 EDWQLIISALILRFAGQLLANGHVGDALLGVGMEPKEFVMLQPELWQKPRHLKRGQLHNLSHSDP 473

  Fly   204 -------RAGLFAHSCTPNLVISIDDEQRIKVYANRFIAAGEILYNCYT----NVLLGTEERRKI 257
                   ...|..|:|.|::....|....:. ||.:.|..||.::||||    |.|  ..:|...
  Fly   474 ITAINLPYLSLCNHACEPSIRTKFDGCSVVN-YAAKDILEGEEIFNCYTMDYRNSL--KLQRSHP 535

  Fly   258 LKVGKCFDCSCPRC--QDPTELGTHMSSFICSQCSCVDGYIVRQPDTGI------WQCLLNPE-- 312
            ||....|:|:|.:|  .||.:.......:.|.:.:|...::   ||..:      |....|.|
  Fly   536 LKAIYKFECTCAKCTRTDPDQNYLSFHRYRCEKPNCRQEFL---PDAKVQQNNLRWWLRCNAEKP 597

  Fly   313 ------HTLK-----QEFV----SNMLERAKEEIFHARDDIYRQELLLAKLSRLLHRNHFLMLDL 362
                  |.|:     .||:    |:.....::.:|.|.||          |.:.|..:|.|...:
  Fly   598 ITCTVCHELQHFAWYNEFLGLIGSSADSSKRQALFKAFDD----------LDKWLVDHHSLKRIM 652

  Fly   363 KQNIASILRQILQNMGTRPNKKVYERKIRLCQEILLVLKV-----VTPGISRLKAIALYE-LANT 421
            .:.:.:.....:.. ||..::..||...|:.::.|..:..     .|..|:|:  ..|:: :|..
  Fly   653 AEELVTACFYEIDG-GTSLDEFEYEDLARIIRKQLEGIAAQCGDNSTEYIARM--TYLWDIIAQK 714

  Fly   422 QAELARKMYTEMEHSANDLLAELERV 447
            :....||...||:...:.|.:|...|
  Fly   715 KCRTDRKELLEMKGKVDYLASEHREV 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-6	NP_611182.1	SET	<179..244	CDD:279228	18/83 (22%)
Smyd4-1	NP_610500.2	zf-MYND	258..298	CDD:280009	9/39 (23%)
Smyd4-1	NP_610500.2	SET	<447..526	CDD:214614	19/79 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810