Protein Alignment SmydA-6 and SMYD1

DIOPT Version :10

• Sequence 1: NP_611182.1
• Gene: SmydA-6 / 36917
• FlyBaseID: FBgn0034183
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_938015.1
• Gene: SMYD1 / 150572
• HGNCID: 20986
• Length: 490
• Species: Homo sapiens
• Alignment Length: 462
• Identity: 96/462 - (20%)
• Similarity: 174/462 - (37%)
• Gaps: 120/462 - (25%)

  Fly    53 CSKCFNLTESF--CRKCRLLALCEDCSDHDERDCKRLAEMNFSDD--QVELLQKKEHTEIQPVLK 113
            |..||...|..  |.:|:....|       :|.|::.|.:|..::  .::...|..:..|:...:
Human    52 CHTCFKRQEKLHRCGQCKFAHYC-------DRTCQKDAWLNHKNECSAIKRYGKVPNENIRLAAR 109

  Fly   114 ---------------CLL----LREHEETLPLYEEMSQMDSQLMTRRGTEVWKNYQEHAFTPLDY 159
                           ||:    |:.|.|.   :.|..|.|.::......:.|.. |...|: :.|
Human   110 IMWRVEREGTGLTEGCLVSVDDLQNHVEH---FGEEEQKDLRVDVDTFLQYWPP-QSQQFS-MQY 169

  Fly   160 GGVLAQLRGAADEDLVQGLLGILDINAYEI---RAPEVGGAMRGLYRRAGLFAHSCTPNLVISID 221
                           :..:.|:::.|.:.:   |..:..|.  |::...||..|.|.||..:..:
Human   170 ---------------ISHIFGVINCNGFTLSDQRGLQAVGV--GIFPNLGLVNHDCWPNCTVIFN 217

  Fly   222 D------------EQRIKVYANRFIAAGEILYNCYTNVLLGTEERRKILKVGKCFDCSCPRCQDP 274
            :            :.||::.|...|:.||.|...|.:.|..:|||::.||....|||:|..||..
Human   218 NGNHEAVKSMFHTQMRIELRALGKISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHCQKK 282

  Fly   275 TELGTHMSSFICSQCSCVDGYIVRQPDTGIWQCLLNPEHTLKQEFVSNMLERAK---EEIFHARD 336
            .:                |...:...|        ||:.:  ||.|..|::.:|   |:|..||.
Human   283 LK----------------DDLFLGVKD--------NPKPS--QEVVKEMIQFSKDTLEKIDKARS 321

  Fly   337 D-IYRQELLLAKLSR-LLHRNHFLMLDLK---QNIASILRQILQNMGTRPNKKVYERKIRLCQEI 396
            : :|.:   :.||.| .|.:...:..|..   ..:.||:.::|..:........|.|::     :
Human   322 EGLYHE---VVKLCRECLEKQEPVFADTNIYMLRMLSIVSEVLSYLQAFEEASFYARRM-----V 378

  Fly   397 LLVLKVVTPGISRL-KAIALYELANTQA---ELARKMYTE------MEHS-ANDLLAELERVEVM 450
            ...:|:..|..::| .|:....|.|..|   |:...|..:      :.|. ::.:..:||.:.|.
Human   379 DGYMKLYHPNNAQLGMAVMRAGLTNWHAGNIEVGHGMICKAYAILLVTHGPSHPITKDLEAMRVQ 443

  Fly   451 LRESLRM 457
            ....|||
Human   444 TEMELRM 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-6	NP_611182.1	SET_SMYD	<185..271	CDD:380997	28/100 (28%)
SMYD1	NP_938015.1	SET_SMYD1	7..281	CDD:380924	55/257 (21%)
		zf-MYND	52..90	CDD:460312	11/44 (25%)