DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SmydA-6 and SMYD5

DIOPT Version :9

Sequence 1:	NP_611182.1	Gene:	SmydA-6 / 36917	FlyBaseID:	FBgn0034183	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_006053.2	Gene:	SMYD5 / 10322	HGNCID:	16258	Length:	418	Species:	Homo sapiens

Alignment Length:	359	Identity:	71/359 - (19%)
Similarity:	109/359 - (30%)	Gaps:	120/359 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GRFAVALCNVRAGETLLLENPIVVLPLMGE-----RRCSKCFNLTESF----------------- 63
            |.||..|  :|.|||:.:|.|:|....:..     |.|..|....|..
Human    35 GLFATQL--IRKGETIFVERPLVAAQFLWNALYRYRACDHCLRALEKAEENAQRLTGKPGQVLPH 97

  Fly    64 -------------CRKCRLLALCEDCSDHDERDCKRLAEMNF---------SDDQVELLQKKEHT 106
                         |..|:::.    ||    .:|:..|...:         .||.:..|.|.:..
Human    98 PELCTVRKDLHQNCPHCQVMY----CS----AECRLAATEQYHQVLCPGPSQDDPLHPLNKLQEA 154

  Fly   107 ----EIQPVLKCLLL-----------------------------REHEETL-PLYEEMSQMDSQL 137
                ...|....::|                             .|.||.: .|..:..:...:|
Human   155 WRSIHYPPETASIMLMARMVATVKQAKDKDRWIRLFSQFCNKTANEEEEIVHKLLGDKFKGQLEL 219

  Fly   138 MTRRGTEVWKNYQEHA---FTPLDYGGVLAQL----RGAADEDLVQGLLGILDINAYEIRAPEVG 195
            :.|..||..  |:|..   |||..:..:.|.:    :|.....|.|.:.....:........::.
Human   220 LRRLFTEAL--YEEAVSQWFTPDGFRSLFALVGTNGQGIGTSSLSQWVHACDTLELKPQDREQLD 282

  Fly   196 GAMRGLYR-------------RAGLFA------HSCTPNLVISIDDEQ-RIKVYANRFIAAGEIL 240
            ..:..||:             .:|||.      |||.||...|..:.. .:.|.|...|..||.:
Human   283 AFIDQLYKDIEAATGEFLNCEGSGLFVLQSCCNHSCVPNAETSFPENNFLLHVTALEDIKPGEEI 347

  Fly   241 YNCYTNVL---LGTEERRKILKVGKCFDCSCPRC 271
            ...|.:..   .....|.|||:....|.||||:|
Human   348 CISYLDCCQRERSRHSRHKILRENYLFVCSCPKC 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-6	NP_611182.1	SET	<179..244	CDD:279228	16/84 (19%)
SMYD5	NP_006053.2	SET	<298..351	CDD:214614	14/52 (27%)
SMYD5	NP_006053.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..418
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810