DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SmydA-7 and smyd1b

DIOPT Version :9

Sequence 1:	NP_001261039.1	Gene:	SmydA-7 / 36916	FlyBaseID:	FBgn0034182	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_001034725.1	Gene:	smyd1b / 569027	ZFINID:	ZDB-GENE-060522-1	Length:	486	Species:	Danio rerio

Alignment Length:	527	Identity:	100/527 - (18%)
Similarity:	179/527 - (33%)	Gaps:	138/527 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GRHLVASIAIEPGDTILEERPLLVAPHWECHQLKCAQCL--QESYVICRRCQVFPLC-MDCN--- 75
            ||.|.|:.....||.:..|.|.............|..|.  ||....|.:|:....| ..|.
Zfish    13 GRGLRATKEAWAGDVLFAEPPFASVVFDSQASSICHSCFRRQEKLQRCGQCRFAQYCDKTCQRAG 77

  Fly    76 -QHDEFECEFFTSGAGKALCKDILVKNFGICGLLKLLLLLENPRTKGDCQMLIDVPINLSDYRDG 139
             :..:.||              ..:|.:|            .|.::.     :.:...:....|.
Zfish    78 WEEHKLEC--------------AAIKTYG------------KPPSEN-----VRLAARILWRMDK 111

  Fly   140 EGMWQEHEELVVRPLMESGLADVLP--------------------TQELTSDALHAHCIR-IDSN 183
            :|......:|.....:|..:.|:..                    ::..|.|:: :|.:. |:.|
Zfish   112 QGSVVSDNQLTTLEDLEDHICDISEDDLKDFKVDIHNFLDYWPRNSKPHTVDSV-SHILGVINCN 175

  Fly   184 SFEVTAKDGDTLKGIFVWG--ATLPHHCVPNTVV--------ALDEQFN----MKLYAAVPLQPG 234
            .|.|:.:.|....|:.::.  ..:.|.|.||..|        |:|..|:    ::|.|...:..|
Zfish   176 GFMVSDQRGLQAVGVGLFPNLCLVNHDCWPNCTVILNNGNQSAIDTVFHSQKRIELRALGKISAG 240

  Fly   235 DIIYNSYTNPLMGTSQRQHQLRLSRRLECICSRCL----DPTEM-GTHMSSLK-----CKECPGF 289
            :.:..:|.:.|..::.||..|:.....:|.|..|.    |..:| |..:..:|     .||...|
Zfish   241 EEVTVAYVDYLNVSADRQRLLKQQYFFDCTCKHCTEKIKDDLKMAGAEVDGVKVPEEQVKEVTEF 305

  Fly   290 S--------VCEIDSNGKLGDWRCPDC--RALLTAAEVHELQAAVGSALVDAMGDLQVYE----- 339
            |        ...|::|.......|.:|  :.....|:.|.....|...|.:.:..||.::
Zfish   306 SRQKLEKMEKARIEANYNEVVKICRECVEKQENVLADTHIYYLRVCCTLSEVLSYLQFFDEASEY 370

  Fly   340 --ALLTQYGPLLHPNHFMLLDIKQNIASILRAAALMNSMDQPCKKLLARRVELCSDLLPVCRAVV 402
              .::..|..|.|||:               |...|.:|........|..:|:...:  :|:|
Zfish   371 ARKMVDGYLKLYHPNN---------------AQLGMATMRAGVTHWQAGFIEVAHGM--ICKA-- 416

  Fly   403 PGISKLYAIGLFEY-----LLALVELVELQFAESDL---SKKEYVAHLRTASLVATEAMDLLRFE 459
                  :||.:..:     :...:|.:.:| .|.:|   .:.|||.|....:.:..:.|.::. |
Zfish   417 ------FAILMITHGPTHPITKDLEAMRMQ-TEMELRMFQQNEYVYHSMREAALKNQPMRMMA-E 473

  Fly   460 PENSAEG 466
            |.|  ||
Zfish   474 PTN--EG 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-7	NP_001261039.1	None
smyd1b	NP_001034725.1	zf-MYND	47..85	CDD:280009	8/37 (22%)
smyd1b	NP_001034725.1	SET	<173..247	CDD:214614	16/73 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D981799at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820