DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF2 and ARHGEF11

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:XP_006711722.1 Gene:ARHGEF11 / 9826 HGNCID:14580 Length:1579 Species:Homo sapiens


Alignment Length:2276 Identity:505/2276 - (22%)
Similarity:778/2276 - (34%) Gaps:836/2276 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   204 QSDNSNPVLQAPGERSSLNLTPLSRDLSGGHTQESTTPATTPSTPSLALPKNFQYLTLTVRKDSN 268
            ||..|:|:.......|||..:...|.....|.|.|....||.......:          ::||.:
Human    17 QSHLSSPIAAWLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVI----------IQKDQH 71

  Fly   269 GYGMKVSGDNPVFVESVKPGGAAEIAGLVAGDMILRVNGHEVRLEKHPTVVGLIKASTTVELAVK 333
            |:|..||||..|.|:||:|||||..||:..||.|::|||..|....|..||.|||:...|.|.:.
Human    72 GFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL 136

  Fly   334 RSQKLTRPSSVSV-----------------VTPSTPILSGRDRTASITGPQPVDSIKRREMETYK 381
            .|.    |||:.:                 |.||.|..........||||:|   ::..|::.:.
Human   137 GSS----PSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKP---LQDPEVQKHA 194

  Fly   382 IQTLQKMLEQEKLNLERLKSDQNNPSYKLSEANIRKLREQLHQVGAEDAPTVKLQAAAGNKNTAL 446
            .|.|:.||.||:..|:|:                                     ....::|.|.
Human   195 TQILRNMLRQEEKELQRI-------------------------------------CEVYSRNPAS 222

  Fly   447 LTPNQIQHLSASATHSNQQFHHLHHHHNLHNNNYPPQQQPASTSPAFLSLLPRSLSSLSLGTRKN 511
            |...||:                                                     |.|:.
Human   223 LLEEQIE-----------------------------------------------------GARRR 234

  Fly   512 KTEKDLTTSSPFGLTTDFLQQQRMSHQAESMSQSMHQHTSTPTSQQFFHPHQQQHRFKETGPTSK 576
            .|:..|......|.:.|.|...                                      |.|| 
Human   235 VTQLQLKIQQETGGSVDILPLY--------------------------------------GDTS- 260

  Fly   577 GKNKFLISRSLIEEDVPPPLPQRNPPRQLNLDLKNGNASPGGSHLVAPVSDLDRATSPQLNRSQQ 641
                                 ||....:|:||.:.|::.                          
Human   261 ---------------------QRPSEGRLSLDSQEGDSG-------------------------- 278

  Fly   642 QQLPSSTDNSPSNAKSKRSKIKTKALSDPKMSTQMFLQMESASAAGAAGGSIEVDGGPPPLPPRL 706
              |.|.|:..||.::|..:  :...||||.:.:                             || 
Human   279 --LDSGTERFPSLSESLMN--RNSVLSDPGLDS-----------------------------PR- 309

  Fly   707 PGMMTEDMSRGSCQNLAQPNSVGTAFNYPLVSTTTAVQNDNLNIAFPLSQRPNIVQQLQQYQQQQ 771
                                      ..|::....|                             
Human   310 --------------------------TSPVIMARVA----------------------------- 319

  Fly   772 QHQMSGGQATGALGQTPNLGKNKHRRVGSSPDNMHPRHPDRITKTTSGSWEIVEKDGESSPPGTP 836
            ||                     |||.||.                    ..|...|:.....:|
Human   320 QH---------------------HRRQGSD--------------------AAVPSTGDQGVDQSP 343

  Fly   837 PPPYLSSSHMTVLEDPNENNRGAAAAGPGVFIESHQFTPMAGASSPIPISLHSSHMHAAQSNDTQ 901
            .|         ::..|.|:      ..||.|                               :.:
Human   344 KP---------LIIGPEED------YDPGYF-------------------------------NNE 362

  Fly   902 KEIISMEDENSDLDEPFIDENGPFNNLTRLLEAENVTFLAIFLNYVISNSDPAPLLFYLITELYK 966
            .:||                   |.:|.:|  ......|.:||.|:.|.:||:||||||..|:|:
Human   363 SDII-------------------FQDLEKL--KSRPAHLGVFLRYIFSQADPSPLLFYLCAEVYQ 406

  Fly   967 EGTSKDMRKWAYEIHSTFLVPRAPLSWYRQDESLAREVDNVLQLEYDKVEILRTVFLRSRKRAKD 1031
            :.:.||.|....:|.:.||...|||. .:..|.|..|:|:.|:...|    .|.|...:::.|..
Human   407 QASPKDSRSLGKDIWNIFLEKNAPLR-VKIPEMLQAEIDSRLRNSED----ARGVLCEAQEAAMP 466

  Fly  1032 LISEQLREFQQKRTAGLGTIYGPTDDKLAEAKTDKLRE-QIIDKYL--MPNLHALIEDENGSPPE 1093
            .|.||:.:::.|||.|||::||..|  |.:...|.||| |:.:|.|  :.::.:..|::..:|.:
Human   467 EIQEQIHDYRTKRTLGLGSLYGEND--LLDLDGDPLRERQVAEKQLAALGDILSKYEEDRSAPMD 529

  Fly  1094 DVRKVALCSALSTVIYRIFNTRPPPSSIVERVHHFVSRDKSFKSRIMGKNRKMNVRGHPLVLRQY 1158
                .||.:.:|....|:...|  ||:..|:......:||                         
Human   530 ----FALNTYMSHAGIRLREAR--PSNTAEKAQSAPDKDK------------------------- 563

  Fly  1159 YEVTHCNHCQTIIWGVSPQGYHCTDCKLNIHRQCSKVVDESCPGPLPQAKRLAHNDKISKFMGKI 1223
                         |                           .|. .|:.|:.:.|.|..|     
Human   564 -------------W---------------------------LPF-FPKTKKQSSNSKKEK----- 582

  Fly  1224 RPRTSDVIGNEKRSRQDEELDVELTPDRGQASIVRQPSDRRPDANISIRSNGNTSCNTSGLNTTD 1288
                 |.:.::||                                       |......|...:.
Human   583 -----DALEDKKR---------------------------------------NPILKYIGKPKSS 603

  Fly  1289 LQSSFHGSCANDSINPGGGAGCNMDLSTSVASTTPSTSGSVAAGLSAFAELNALDTVDKEARRER 1353
            .||:||...:...:.||...........:.....|. .|:......:|.|    |.::.::.|  
Human   604 SQSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDAPE-PGTQRLSTGSFPE----DLLESDSSR-- 661

  Fly  1354 YSQHPKHKSAPVSVNRSESYKERLSNKRNR---NSRRKTSDPSLSSRPNDEQLDLGLSNATYVGS 1415
                     :.:.:.||||.|.|...||:|   |..|..||..:.:.....:|....|      |
Human   662 ---------SEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSAS------S 711

  Fly  1416 SNSSLSSAGGSESPSTSMEHFAAPGAAGGVQVPPMGL-NQNQHPHLLIQQHAQQYCQQDSFQAGL 1479
            |.||||:. ..|:|:..   |........::.|.:|. .....||||         :.|..|.  
Human   712 STSSLSTR-SLENPTPP---FTPKMGRRSIESPSLGFCTDTLLPHLL---------EDDLGQL-- 761

  Fly  1480 AGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEADWSSMVAAEVLAALTDAEKKRQEIIN 1544
                                         |:.|.:.:..:|...|..:|:|.||..|..|||:||
Human   762 -----------------------------SDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVIN 797

  Fly  1545 EIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFP--PALLSLREIHGAFEQSLKQRRIE 1607
            |::.||.:|:|||::||.:|:..:.:..|:.::.|..|||  |.|:   |||.::.:::|:.| |
Human   798 ELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELI---EIHNSWCEAMKKLR-E 858

  Fly  1608 HNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKAC 1672
            ...::..|.||:...|||.:...|.:.|||||:.|.||||.:|.|:.|:...|..::::|||..|
Human   859 EGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQC 923

  Fly  1673 RRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTA 1737
            |||:|:||:.:.:|||||||||.|::.|.|    ...|:|.|.:.||.:..:.||..||:|||..
Human   924 RRLQLRDLIISEMQRLTKYPLLLESIIKHT----EGGTSEHEKLCRARDQCREILKYVNEAVKQT 984

  Fly  1738 EDAHKLQNIQRKLDRSSYDK------EEFKKLDLTQHHLIHDGNLT--IKKNPSVQLHGLLFENM 1794
            |:.|:|:..|::||.::.::      .|||.||||...:||:|.||  |.|:.::.||.||.|::
Human   985 ENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDL 1049

  Fly  1795 IVLLTKQDDKYYLKNLHTPLSI----TNKPVSPIMSIDADTLIRQEAADKNSFFLI---KMKTSQ 1852
            :|||.|||:|..|| .|:..::    :.:..||::.::| .|||..|.||.:||:|   |:...|
Human  1050 LVLLQKQDEKLLLK-CHSKTAVGSSDSKQTFSPVLKLNA-VLIRSVATDKRAFFIICTSKLGPPQ 1112

  Fly  1853 MLELRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDTSISDPALAAIPHSNTKESLELSTDT 1917
            :.||.|.:||:..||.:...:..        :||:.:       |..|.:|              
Human  1113 IYELVALTSSDKNTWMELLEEAV--------RNATRH-------PGAAPMP-------------- 1148

  Fly  1918 VQPLAATATLTTTPLAPMLPIATVTPAPA---TNNSNV-------SSLTG-------------VQ 1959
            |.|         .|..|..| |...|.|:   .::|:|       ..|.|             |.
Human  1149 VHP---------PPPGPREP-AQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVL 1203

  Fly  1960 LRNPQRDATASESDADYVNTPKPRSSQNEVNRTMSIRS------TGEPIQKYSANGTEANDVTLR 2018
            |.:|:::.:|.|.:...:  |.|.:|.:..||.:..|:      .|....:..|:....:...||
Human  1204 LEDPEQEGSAEEEELGVL--PCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLR 1266

  Fly  2019 HSQSTRESVRPGSTGEERNSTYGMVGGNSKRDSASIVCSNNSNNTRTLLMQSPLVD----PTAIQ 2079
            |  ....|:.||.|.|                              |...|.|..|    |:.|.
Human  1267 H--LILWSLLPGHTME------------------------------TQAAQEPEDDLTPTPSVIS 1299

  Fly  2080 VSISPAHTAEPVLTP--GEKLRRLDASIRNDLLEKQKI-ICDIFRLPVEHYDQIVDIAMMPEAPK 2141
            |:..|.....|...|  ||......|.:..:..|::.: :|.:..||....:.  .|...||..:
Human  1300 VTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNS--GIWESPELDR 1362

  Fly  2142 D-----SADIALAAYDQIQTLTKMLNEYMHVTPEQ--------EVSAVSTAVCGHCHEKEKLRKK 2193
            :     |:..|...|..::......::.:...||.        ||.. .|...|:|....  ...
Human  1363 NLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPESGQSEPGPPEVEG-GTKATGNCFYVS--MPS 1424

  Fly  2194 VAPSSSFSSSPPPLPPPNRQ-----HAQAQAQIP--------PSRLMPKLQTLDLDEVAIHEDDD 2245
            ..|.||...|..|:.||...     ..:.|.|:.        |||..|.|...|:..:       
Human  1425 GPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMI------- 1482

  Fly  2246 GYCEIDELRLPAIPSKPHERP---------------TTPLAPFNTEPK--TSQSVIDASKRQSTD 2293
             :..|::|.|.....|..|..               |||:..|:||..  |..|:...:|     
Human  1483 -FHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAK----- 1541

  Fly  2294 AVPEGLLEQEPLEGDKTETKGEDNEVKTVPSDKLSESCNEERQCVEADITKEVADPTTSKNEAAA 2358
                     |||..|                   |.:.:|...|.|......:.|.|.   :|||
Human  1542 ---------EPLASD-------------------SRNSHELGPCPEDGSDAPLEDSTA---DAAA 1575

  Fly  2359 S 2359
            |
Human  1576 S 1576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570 34/73 (47%)
RGS_GEF_like 934..1055 CDD:188710 44/120 (37%)
C1_1 1151..1202 CDD:278556 1/50 (2%)
RhoGEF 1539..1731 CDD:238091 78/193 (40%)
PH_RhoGEF 1770..1875 CDD:275411 43/113 (38%)
DUF2413 2242..>2378 CDD:287302 28/135 (21%)
ARHGEF11XP_006711722.1 PDZ_signaling 62..136 CDD:238492 34/83 (41%)
DegQ <77..155 CDD:223343 34/81 (42%)
RGS_PDZRhoGEF 346..490 CDD:188707 54/206 (26%)
RhoGEF 795..979 CDD:279015 76/191 (40%)
PH_PRG 996..1138 CDD:275426 52/151 (34%)
PH <1056..1136 CDD:278594 27/89 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 138 1.000 Domainoid score I4844
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 332 1.000 Inparanoid score I2429
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D163264at33208
OrthoFinder 1 1.000 - - FOG0001574
OrthoInspector 1 1.000 - - otm41901
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR45872
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3275
SonicParanoid 1 1.000 - - X2399
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.960

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