DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF2 and ARHGEF2

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:XP_011508441.1 Gene:ARHGEF2 / 9181 HGNCID:682 Length:1139 Species:Homo sapiens


Alignment Length:1156 Identity:262/1156 - (22%)
Similarity:413/1156 - (35%) Gaps:350/1156 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1172 WGVSPQGYHCTDCKLNIHR-QCSKVVDESCPGPLPQAKRLAHNDKISKFMGKIRPRTSDVIGNEK 1235
            ||...:    .:..||..| |.|     .||||           |.:.|: :||......:|.:.
Human    29 WGPGRE----LEGPLNTRRLQAS-----GCPGP-----------KEALFL-QIREGLDTFLGLQH 72

  Fly  1236 RSRQDEELDVE-LTPDRGQASIVRQPSDRRPDANISIRSNGNTSCNTSGLNTTDLQSSFHGSCAN 1299
            :......||.: ..|..|       |.|......:|      .|...||:|....:|...|:.:.
Human    73 QGGYASRLDQDSCHPSAG-------PLDHSATGMLS------KSVPVSGINCLLDRSDTDGNVSQ 124

  Fly  1300 DSINPGGGAGCNMDL-----------STSVASTTPSTSGSVAAGLSAFAELNALDTVDKEARRER 1353
            .|.         :||           .|.|.|:...|. |..:|::..|:....:.: |||:..|
Human   125 SSA---------IDLRKRCSQLEGHSGTRVGSSLRQTF-SFLSGMTGKAKTREKEKM-KEAKDAR 178

  Fly  1354 YSQHPKHKSAPVSV---------NRSESYKERLSNKRNRNSRRKTSDPSLSSRPNDEQLDLGLSN 1409
            |:.  .|....:||         |:|.:.||.|.        ..|.:.::.:|..|.     |:|
Human   179 YTN--GHLFTTISVSGMTMCYACNKSITAKEALI--------CPTCNVTIHNRCKDT-----LAN 228

  Fly  1410 ATYVG---------SSNSSLSSAGGSESPSTSMEHFAAPGAAGGVQVPPMGLNQNQHPHLLIQQH 1465
            .|.|.         .:|::|.|. ...|.:|..|.   |.:|    :.|                
Human   229 CTKVKQKQQKAALLKNNTALQSV-SLRSKTTIRER---PSSA----IYP---------------- 269

  Fly  1466 AQQYCQQDSFQAGLAGA----AGSSAASNSSFWN-AGH-----PLPVARWTLESED--------- 1511
                  .|||:..|.|:    :..|.|.:.|..| |||     ||.:.|...:|.|         
Human   270 ------SDSFRQSLLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTL 328

  Fly  1512 --EDDVNEAD---------------------WSSMVAAEVLAALTDAEKKRQEIINEIYQTERNH 1553
              |..::||:                     ||..|.:..|........|:|::|.|:.|||.:|
Human   329 SVESLIDEAEVIYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHH 393

  Fly  1554 VRTLKLLDRLFFLPLYESGLLSQDHL-----LLLFPPALLSLREIHGAFEQSLKQRRIE------ 1607
            |||||::.|||     .:|:|.:.||     ..|| |.:..|.:||..|...|.:||.:      
Human   394 VRTLKIMTRLF-----RTGMLEELHLEPGVVQGLF-PCVDELSDIHTRFLSQLLERRRQALCPGS 452

  Fly  1608 -HNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKA 1671
             .|.|::.:||||...|.|.|...:|:..::||:|...||:..||...:|:..|:.::|......
Human   453 TRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAV 517

  Fly  1672 CRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPEN---TTEAEAIQRAVESSKRILVEVNQA 1733
            .:|..:::.:..|.||:||||||..       |:|..:   ..|.:.:..|:...|.:|..|::.
Human   518 LKRHGVQECILLVTQRITKYPLLIS-------RILQHSHGIEEERQDLTTALGLVKELLSNVDEG 575

  Fly  1734 VKTAEDAHKLQNIQRKLDRSSY----DKEEFKKLDLTQHHLIHDGNLTIK------KNPSVQLHG 1788
            :...|...:||.|..::|..:.    .|..|.:.:|.:..|||||.|..|      |:..|    
Human   576 IYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLV---- 636

  Fly  1789 LLFENMIVLLTKQDDKYYLKNLHTPLSITNKPVSPIMSIDADTLIRQEAADKNSFFLIKMKTSQM 1853
            ||..:::|.|.::|.||....|..|         .::|:. :.::|..|..:...|||.....:|
Human   637 LLMTDVLVFLQEKDQKYIFPTLDKP---------SVVSLQ-NLIVRDIANQEKGMFLISAAPPEM 691

  Fly  1854 LELRAPSSSECKTWFK------------------HFSDVA-------ARQSKNRS---------- 1883
            .|:...|..:..||.:                  ...|.|       ..|.|:|:          
Human   692 YEVHTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKMELQQKDRALVELLREKVG 756

  Fly  1884 KNASSNH----DTSISDPALAAIPHSNTK-ESLE------LSTDTVQPLAAT--------ATLTT 1929
            ..|...|    :...|..||..:|....: ||||      |..|.::.:...        ..|..
Human   757 LFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGPGVELLL 821

  Fly  1930 TPLAPMLPI-----ATVTPAPATN-----------------NSNVSSLTGVQLRNPQRD------ 1966
            ||..|.||:     ...:|....|                 :|:.....|.|||:||.:      
Human   822 TPREPALPLEPDSGGNTSPGVTANGEARTFNGSIELCRADSDSSQRDRNGNQLRSPQEEALQRLV 886

  Fly  1967 ----------ATASESD----ADYVNTPKPRSSQNEVNRT--MSIRSTGEPIQKYSANGTEANDV 2015
                      |..::.|    |.:...|:.|......|..  .:.|:...|:    |...:|.::
Human   887 NLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPV----APEKQATEL 947

  Fly  2016 TL---RHSQSTRESVRPGSTGEERNSTYGMVGGNSKR-DSASIVCSNNSNNTRTLL----MQSPL 2072
            .|   :|:....|..|....||||.:..|.:....:. :.|..:....:...|..|    ...||
Human   948 ALLQRQHALLQEELRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEARRQLAALGQTEPL 1012

  Fly  2073 ----------VDP--------TAIQVSISPAHTAEPVLTPGEKLRRLDASI 2105
                      |||        .|:.:|.:|..       |.....|||..:
Human  1013 PAEAPWARRPVDPRRRSLPAGDALYLSFNPPQ-------PSRGTDRLDLPV 1056

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710
C1_1 1151..1202 CDD:278556 8/30 (27%)
RhoGEF 1539..1731 CDD:238091 65/206 (32%)
PH_RhoGEF 1770..1875 CDD:275411 30/128 (23%)
DUF2413 2242..>2378 CDD:287302
ARHGEF2XP_011508441.1 C1 183..228 CDD:237996 12/57 (21%)
RhoGEF 379..573 CDD:238091 65/206 (32%)
PH_ARHGEF2 613..728 CDD:275428 29/128 (23%)
PH 616..714 CDD:278594 29/111 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146543
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.740

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